Legume Lectins with Different Specificities as Potential Glycan Probes for Pathogenic Enveloped Viruses
Pathogenic enveloped viruses are covered with a glycan shield that provides a dual function: the glycan structures contribute to virus protection as well as host cell recognition. The three classical types of <i>N</i>-glycans, in particular complex glycans, high-mannose glycans, and hybr...
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MDPI AG
2022-01-01
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| author | Annick Barre Els J. M. Van Damme Bernard Klonjkowski Mathias Simplicien Jan Sudor Hervé Benoist Pierre Rougé |
| author_facet | Annick Barre Els J. M. Van Damme Bernard Klonjkowski Mathias Simplicien Jan Sudor Hervé Benoist Pierre Rougé |
| author_sort | Annick Barre |
| collection | DOAJ |
| description | Pathogenic enveloped viruses are covered with a glycan shield that provides a dual function: the glycan structures contribute to virus protection as well as host cell recognition. The three classical types of <i>N</i>-glycans, in particular complex glycans, high-mannose glycans, and hybrid glycans, together with some <i>O</i>-glycans, participate in the glycan shield of the Ebola virus, influenza virus, human cytomegalovirus, herpes virus, human immunodeficiency virus, Lassa virus, and MERS-CoV, SARS-CoV, and SARS-CoV-2, which are responsible for respiratory syndromes. The glycans are linked to glycoproteins that occur as metastable prefusion glycoproteins on the surface of infectious virions such as gp120 of HIV, hemagglutinin of influenza, or spike proteins of beta-coronaviruses. Plant lectins with different carbohydrate-binding specificities and, especially, mannose-specific lectins from the Vicieae tribe, such as pea lectin and lentil lectin, can be used as glycan probes for targeting the glycan shield because of their specific interaction with the α1,6-fucosylated core Man<sub>3</sub>GlcNAc<sub>2</sub>, which predominantly occurs in complex and hybrid glycans. Other plant lectins with Neu5Ac specificity or GalNAc/T/Tn specificity can also serve as potential glycan probes for the often sialylated complex glycans and truncated <i>O</i>-glycans, respectively, which are abundantly distributed in the glycan shield of enveloped viruses. The biomedical and therapeutical potential of plant lectins as antiviral drugs is discussed. |
| first_indexed | 2024-03-10T00:05:01Z |
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| last_indexed | 2024-03-10T00:05:01Z |
| publishDate | 2022-01-01 |
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| series | Cells |
| spelling | doaj.art-200a76c4c5d24279b919a527dfd8c08a2023-11-23T16:10:16ZengMDPI AGCells2073-44092022-01-0111333910.3390/cells11030339Legume Lectins with Different Specificities as Potential Glycan Probes for Pathogenic Enveloped VirusesAnnick Barre0Els J. M. Van Damme1Bernard Klonjkowski2Mathias Simplicien3Jan Sudor4Hervé Benoist5Pierre Rougé6UMR 152 PharmaDev, Institut de Recherche et Développement, Faculté de Pharmacie, Université Paul Sabatier, 35 Chemin des Maraîchers, F-31062 Toulouse, FranceDepartment of Biotechnology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, BelgiumUMR Virologie, INRA, ANSES, Ecole Nationale Vétérinaire d’Alfort, F-94700 Maisons-Alfort, FranceUMR 152 PharmaDev, Institut de Recherche et Développement, Faculté de Pharmacie, Université Paul Sabatier, 35 Chemin des Maraîchers, F-31062 Toulouse, FranceUMR 152 PharmaDev, Institut de Recherche et Développement, Faculté de Pharmacie, Université Paul Sabatier, 35 Chemin des Maraîchers, F-31062 Toulouse, FranceUMR 152 PharmaDev, Institut de Recherche et Développement, Faculté de Pharmacie, Université Paul Sabatier, 35 Chemin des Maraîchers, F-31062 Toulouse, FranceUMR 152 PharmaDev, Institut de Recherche et Développement, Faculté de Pharmacie, Université Paul Sabatier, 35 Chemin des Maraîchers, F-31062 Toulouse, FrancePathogenic enveloped viruses are covered with a glycan shield that provides a dual function: the glycan structures contribute to virus protection as well as host cell recognition. The three classical types of <i>N</i>-glycans, in particular complex glycans, high-mannose glycans, and hybrid glycans, together with some <i>O</i>-glycans, participate in the glycan shield of the Ebola virus, influenza virus, human cytomegalovirus, herpes virus, human immunodeficiency virus, Lassa virus, and MERS-CoV, SARS-CoV, and SARS-CoV-2, which are responsible for respiratory syndromes. The glycans are linked to glycoproteins that occur as metastable prefusion glycoproteins on the surface of infectious virions such as gp120 of HIV, hemagglutinin of influenza, or spike proteins of beta-coronaviruses. Plant lectins with different carbohydrate-binding specificities and, especially, mannose-specific lectins from the Vicieae tribe, such as pea lectin and lentil lectin, can be used as glycan probes for targeting the glycan shield because of their specific interaction with the α1,6-fucosylated core Man<sub>3</sub>GlcNAc<sub>2</sub>, which predominantly occurs in complex and hybrid glycans. Other plant lectins with Neu5Ac specificity or GalNAc/T/Tn specificity can also serve as potential glycan probes for the often sialylated complex glycans and truncated <i>O</i>-glycans, respectively, which are abundantly distributed in the glycan shield of enveloped viruses. The biomedical and therapeutical potential of plant lectins as antiviral drugs is discussed.https://www.mdpi.com/2073-4409/11/3/339enveloped virusEbola virusHIVherpes simplex virushuman cytomegalovirusinfluenza virus |
| spellingShingle | Annick Barre Els J. M. Van Damme Bernard Klonjkowski Mathias Simplicien Jan Sudor Hervé Benoist Pierre Rougé Legume Lectins with Different Specificities as Potential Glycan Probes for Pathogenic Enveloped Viruses Cells enveloped virus Ebola virus HIV herpes simplex virus human cytomegalovirus influenza virus |
| title | Legume Lectins with Different Specificities as Potential Glycan Probes for Pathogenic Enveloped Viruses |
| title_full | Legume Lectins with Different Specificities as Potential Glycan Probes for Pathogenic Enveloped Viruses |
| title_fullStr | Legume Lectins with Different Specificities as Potential Glycan Probes for Pathogenic Enveloped Viruses |
| title_full_unstemmed | Legume Lectins with Different Specificities as Potential Glycan Probes for Pathogenic Enveloped Viruses |
| title_short | Legume Lectins with Different Specificities as Potential Glycan Probes for Pathogenic Enveloped Viruses |
| title_sort | legume lectins with different specificities as potential glycan probes for pathogenic enveloped viruses |
| topic | enveloped virus Ebola virus HIV herpes simplex virus human cytomegalovirus influenza virus |
| url | https://www.mdpi.com/2073-4409/11/3/339 |
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