The addition of a developmental factor, unc-62, to already long-lived worms increases lifespan and healthspan
Aging is a complex trait that is affected by multiple genetic pathways. A relatively unexplored approach is to manipulate multiple independent aging pathways simultaneously in order to observe their cumulative effect on lifespan. Here, we report the phenotypic characterization of a strain with chang...
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| Format: | Article |
| Language: | English |
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The Company of Biologists
2017-12-01
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| Series: | Biology Open |
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| Online Access: | http://bio.biologists.org/content/6/12/1796 |
| _version_ | 1818461276072837120 |
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| author | Dror Sagi |
| author_facet | Dror Sagi |
| author_sort | Dror Sagi |
| collection | DOAJ |
| description | Aging is a complex trait that is affected by multiple genetic pathways. A relatively unexplored approach is to manipulate multiple independent aging pathways simultaneously in order to observe their cumulative effect on lifespan. Here, we report the phenotypic characterization of a strain with changes in five aging pathways: (1) mitochondrial reactive oxygen species (ROS) production, (2) innate immunity, (3) stress response, (4) metabolic control and (5) developmental regulation in old age. The quintuply modified strain has a lifespan that is 160% longer than the transgenic control strain. Additionally, the quintuply modified strain maintains several physiological markers of aging for a longer time than the transgenic control. Our results support a modular approach as a general scheme to study how multiple pathways interact to achieve extreme longevity. |
| first_indexed | 2024-12-14T23:43:34Z |
| format | Article |
| id | doaj.art-200bbab7920f432ea541a82dc61dcff5 |
| institution | Directory Open Access Journal |
| issn | 2046-6390 |
| language | English |
| last_indexed | 2024-12-14T23:43:34Z |
| publishDate | 2017-12-01 |
| publisher | The Company of Biologists |
| record_format | Article |
| series | Biology Open |
| spelling | doaj.art-200bbab7920f432ea541a82dc61dcff52022-12-21T22:43:28ZengThe Company of BiologistsBiology Open2046-63902017-12-016121796180110.1242/bio.027433027433The addition of a developmental factor, unc-62, to already long-lived worms increases lifespan and healthspanDror Sagi0 Departments of Genetics and Developmental Biology, Stanford University Medical Center, Stanford, CA 94305-5329, USA Aging is a complex trait that is affected by multiple genetic pathways. A relatively unexplored approach is to manipulate multiple independent aging pathways simultaneously in order to observe their cumulative effect on lifespan. Here, we report the phenotypic characterization of a strain with changes in five aging pathways: (1) mitochondrial reactive oxygen species (ROS) production, (2) innate immunity, (3) stress response, (4) metabolic control and (5) developmental regulation in old age. The quintuply modified strain has a lifespan that is 160% longer than the transgenic control strain. Additionally, the quintuply modified strain maintains several physiological markers of aging for a longer time than the transgenic control. Our results support a modular approach as a general scheme to study how multiple pathways interact to achieve extreme longevity.http://bio.biologists.org/content/6/12/1796AgingBioengineeringCaenorhabditis elegans |
| spellingShingle | Dror Sagi The addition of a developmental factor, unc-62, to already long-lived worms increases lifespan and healthspan Biology Open Aging Bioengineering Caenorhabditis elegans |
| title | The addition of a developmental factor, unc-62, to already long-lived worms increases lifespan and healthspan |
| title_full | The addition of a developmental factor, unc-62, to already long-lived worms increases lifespan and healthspan |
| title_fullStr | The addition of a developmental factor, unc-62, to already long-lived worms increases lifespan and healthspan |
| title_full_unstemmed | The addition of a developmental factor, unc-62, to already long-lived worms increases lifespan and healthspan |
| title_short | The addition of a developmental factor, unc-62, to already long-lived worms increases lifespan and healthspan |
| title_sort | addition of a developmental factor unc 62 to already long lived worms increases lifespan and healthspan |
| topic | Aging Bioengineering Caenorhabditis elegans |
| url | http://bio.biologists.org/content/6/12/1796 |
| work_keys_str_mv | AT drorsagi theadditionofadevelopmentalfactorunc62toalreadylonglivedwormsincreaseslifespanandhealthspan AT drorsagi additionofadevelopmentalfactorunc62toalreadylonglivedwormsincreaseslifespanandhealthspan |