Hepatitis E Virus Seroprevalence and Associated Risk Factors in Pregnant Women Attending Antenatal Consultations in Senegal
In West Africa, research on the hepatitis E virus (HEV) is barely covered, despite the recorded outbreaks. The low level of access to safe water and adequate sanitation is still one of the main factors of HEV spread in developing countries. HEV infection induces acute or sub-clinical liver diseases...
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MDPI AG
2022-08-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/8/1742 |
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| author | Abou Abdallah Malick Diouara Seynabou Lo Cheikh Momar Nguer Assane Senghor Halimatou Diop Ndiaye Noël Magloire Manga Fodé Danfakha Sidy Diallo Marie Edouard Faye Dieme Ousmane Thiam Babacar Biaye Ndèye Marie Pascaline Manga Fatou Thiam Habibou Sarr Gora Lo Momar Ndour Sébastien Paterne Manga Nouhou Diaby Modou Dieng Idy Diop Yakhya Dieye Coumba Toure Kane Martine Peeters Ahidjo Ayouba |
| author_facet | Abou Abdallah Malick Diouara Seynabou Lo Cheikh Momar Nguer Assane Senghor Halimatou Diop Ndiaye Noël Magloire Manga Fodé Danfakha Sidy Diallo Marie Edouard Faye Dieme Ousmane Thiam Babacar Biaye Ndèye Marie Pascaline Manga Fatou Thiam Habibou Sarr Gora Lo Momar Ndour Sébastien Paterne Manga Nouhou Diaby Modou Dieng Idy Diop Yakhya Dieye Coumba Toure Kane Martine Peeters Ahidjo Ayouba |
| author_sort | Abou Abdallah Malick Diouara |
| collection | DOAJ |
| description | In West Africa, research on the hepatitis E virus (HEV) is barely covered, despite the recorded outbreaks. The low level of access to safe water and adequate sanitation is still one of the main factors of HEV spread in developing countries. HEV infection induces acute or sub-clinical liver diseases with a mortality rate ranging from 0.5 to 4%. The mortality rate is more alarming (15 to 25%) among pregnant women, especially in the last trimester of pregnancy. Herein, we conducted a multicentric socio-demographic and seroepidemiological survey of HEV in Senegal among pregnant women. A consecutive and non-redundant recruitment of participants was carried out over the period of 5 months, from March to July 2021. A total of 1227 consenting participants attending antenatal clinics responded to a standard questionnaire. Plasma samples were collected and tested for anti-HEV IgM and IgG by using the WANTAI HEV-IgM and IgG ELISA assay. The overall HEV seroprevalence was 7.8% (n = 96), with 0.5% (n = 6) and 7.4% (n = 91) for HEV IgM and HEV IgG, respectively. One of the participant samples was IgM/IgG-positive, while four were declared indeterminate to anti-HEV IgM as per the manufacturer’s instructions. From one locality to another, the seroprevalence of HEV antibodies varied from 0 to 1% for HEV IgM and from 1.5 to 10.5% for HEV IgG. The data also showed that seroprevalence varied significantly by marital status (<i>p</i> < 0.0001), by the regularity of income (<i>p</i> = 0.0043), and by access to sanitation services (<i>p</i> = 0.0006). These data could serve as a basis to setup national prevention strategies focused on socio-cultural, environmental, and behavioral aspects for a better management of HEV infection in Senegal. |
| first_indexed | 2024-03-09T12:21:31Z |
| format | Article |
| id | doaj.art-200e0346ba8e44a3b3c7da9ad94e82aa |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T12:21:31Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-200e0346ba8e44a3b3c7da9ad94e82aa2023-11-30T22:39:15ZengMDPI AGViruses1999-49152022-08-01148174210.3390/v14081742Hepatitis E Virus Seroprevalence and Associated Risk Factors in Pregnant Women Attending Antenatal Consultations in SenegalAbou Abdallah Malick Diouara0Seynabou Lo1Cheikh Momar Nguer2Assane Senghor3Halimatou Diop Ndiaye4Noël Magloire Manga5Fodé Danfakha6Sidy Diallo7Marie Edouard Faye Dieme8Ousmane Thiam9Babacar Biaye10Ndèye Marie Pascaline Manga11Fatou Thiam12Habibou Sarr13Gora Lo14Momar Ndour15Sébastien Paterne Manga16Nouhou Diaby17Modou Dieng18Idy Diop19Yakhya Dieye20Coumba Toure Kane21Martine Peeters22Ahidjo Ayouba23Groupe de Recherche Biotechnologies Appliquées & Bioprocédés environnementaux (GRBA-BE), École Supérieure Polytechnique (ESP)–Université Cheikh Anta Diop, Dakar-Fann, Dakar 5085, SenegalLaboratoire Bactériologie Virologie, Centre Hospitalier Régional de Saint-Louis, Saint-Louis, SenegalGroupe de Recherche Biotechnologies Appliquées & Bioprocédés environnementaux (GRBA-BE), École Supérieure Polytechnique (ESP)–Université Cheikh Anta Diop, Dakar-Fann, Dakar 5085, SenegalGroupe de Recherche Biotechnologies Appliquées & Bioprocédés environnementaux (GRBA-BE), École Supérieure Polytechnique (ESP)–Université Cheikh Anta Diop, Dakar-Fann, Dakar 5085, SenegalLaboratoire de Bactériologie Virologie CHU Aristide le Dantec–Université Cheikh Anta Diop, Dakar-Fann, Dakar 7325, SenegalService des Maladies Infectieuses Hôpital de la Paix de Ziguinchor, Ziguinchor, SenegalDistrict Sanitaire–Région Médicale de Kédougou, Kédougou, SenegalService Hépato-Gastroentérologie, Centre Hospitalier Régional de Saint-Louis, Saint-Louis, SenegalClinique Gynécologique et Obstétricale du Centre Hospitalier Universitaire Nationale Aristide le Dantec–Université Cheikh Anta Diop, Dakar-Fann, Dakar 3001, SenegalUnité de Formation et de Recherche Science de la Santé (UFR 2S)–Université Gaston Berger, Saint-Louis 234, SenegalCentre de Santé Gaspard KAMARA, Dakar 3370, SenegalLaboratoire de Bactériologie Virologie CHU Aristide le Dantec–Université Cheikh Anta Diop, Dakar-Fann, Dakar 7325, SenegalGroupe de Recherche Biotechnologies Appliquées & Bioprocédés environnementaux (GRBA-BE), École Supérieure Polytechnique (ESP)–Université Cheikh Anta Diop, Dakar-Fann, Dakar 5085, SenegalService des Maladies Infectieuses Hôpital de la Paix de Ziguinchor, Ziguinchor, SenegalInstitut de Recherche en Santé, de Surveillance Épidémiologique et de Formation (IRESSEF)–Pole Urbain Diamniadio, Diamniadio 7325, SenegalLaboratoire Bactériologie Virologie, Centre Hospitalier Régional de Saint-Louis, Saint-Louis, SenegalUnité de Formation et de Recherche Science de la Santé–Université Assane Seck de Ziguinchor, Ziguinchor, SenegalLaboratoire de Traitement des Eaux Usées (LATEU) de l’Institut Fondamental d’Afrique Noir (IFAN)–Université Cheikh Anta Diop, Dakar-Fann, Dakar 206, SenegalLaboratoire d’Analyses et Essais, École Supérieure Polytechnique (ESP)–Université Cheikh Anta Diop, Dakar-Fann, Dakar 5085, SenegalLaboratoire d’Imagerie Médicale et BioInformatique, École Supérieure Polytechnique (ESP)–Université Cheikh Anta Diop, Dakar-Fann, Dakar 5085, SenegalGroupe de Recherche Biotechnologies Appliquées & Bioprocédés environnementaux (GRBA-BE), École Supérieure Polytechnique (ESP)–Université Cheikh Anta Diop, Dakar-Fann, Dakar 5085, SenegalInstitut de Recherche en Santé, de Surveillance Épidémiologique et de Formation (IRESSEF)–Pole Urbain Diamniadio, Diamniadio 7325, SenegalRecherches Translationnelles sur le VIH et Maladies Infectieuses, Université de Montpellier/INSERM U1175, Institut de Recherche pour le Développement, 34394 Montpellier, FranceRecherches Translationnelles sur le VIH et Maladies Infectieuses, Université de Montpellier/INSERM U1175, Institut de Recherche pour le Développement, 34394 Montpellier, FranceIn West Africa, research on the hepatitis E virus (HEV) is barely covered, despite the recorded outbreaks. The low level of access to safe water and adequate sanitation is still one of the main factors of HEV spread in developing countries. HEV infection induces acute or sub-clinical liver diseases with a mortality rate ranging from 0.5 to 4%. The mortality rate is more alarming (15 to 25%) among pregnant women, especially in the last trimester of pregnancy. Herein, we conducted a multicentric socio-demographic and seroepidemiological survey of HEV in Senegal among pregnant women. A consecutive and non-redundant recruitment of participants was carried out over the period of 5 months, from March to July 2021. A total of 1227 consenting participants attending antenatal clinics responded to a standard questionnaire. Plasma samples were collected and tested for anti-HEV IgM and IgG by using the WANTAI HEV-IgM and IgG ELISA assay. The overall HEV seroprevalence was 7.8% (n = 96), with 0.5% (n = 6) and 7.4% (n = 91) for HEV IgM and HEV IgG, respectively. One of the participant samples was IgM/IgG-positive, while four were declared indeterminate to anti-HEV IgM as per the manufacturer’s instructions. From one locality to another, the seroprevalence of HEV antibodies varied from 0 to 1% for HEV IgM and from 1.5 to 10.5% for HEV IgG. The data also showed that seroprevalence varied significantly by marital status (<i>p</i> < 0.0001), by the regularity of income (<i>p</i> = 0.0043), and by access to sanitation services (<i>p</i> = 0.0006). These data could serve as a basis to setup national prevention strategies focused on socio-cultural, environmental, and behavioral aspects for a better management of HEV infection in Senegal.https://www.mdpi.com/1999-4915/14/8/1742hepatitis Eassociated risk factorspregnant womenenvironmentpreventionSenegal |
| spellingShingle | Abou Abdallah Malick Diouara Seynabou Lo Cheikh Momar Nguer Assane Senghor Halimatou Diop Ndiaye Noël Magloire Manga Fodé Danfakha Sidy Diallo Marie Edouard Faye Dieme Ousmane Thiam Babacar Biaye Ndèye Marie Pascaline Manga Fatou Thiam Habibou Sarr Gora Lo Momar Ndour Sébastien Paterne Manga Nouhou Diaby Modou Dieng Idy Diop Yakhya Dieye Coumba Toure Kane Martine Peeters Ahidjo Ayouba Hepatitis E Virus Seroprevalence and Associated Risk Factors in Pregnant Women Attending Antenatal Consultations in Senegal Viruses hepatitis E associated risk factors pregnant women environment prevention Senegal |
| title | Hepatitis E Virus Seroprevalence and Associated Risk Factors in Pregnant Women Attending Antenatal Consultations in Senegal |
| title_full | Hepatitis E Virus Seroprevalence and Associated Risk Factors in Pregnant Women Attending Antenatal Consultations in Senegal |
| title_fullStr | Hepatitis E Virus Seroprevalence and Associated Risk Factors in Pregnant Women Attending Antenatal Consultations in Senegal |
| title_full_unstemmed | Hepatitis E Virus Seroprevalence and Associated Risk Factors in Pregnant Women Attending Antenatal Consultations in Senegal |
| title_short | Hepatitis E Virus Seroprevalence and Associated Risk Factors in Pregnant Women Attending Antenatal Consultations in Senegal |
| title_sort | hepatitis e virus seroprevalence and associated risk factors in pregnant women attending antenatal consultations in senegal |
| topic | hepatitis E associated risk factors pregnant women environment prevention Senegal |
| url | https://www.mdpi.com/1999-4915/14/8/1742 |
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