Calcineurin /NFAT activation-dependence of leptin synthesis and vascular growth in response to mechanical stretch

Calcineurin /NFAT activation-dependence of leptin synthesis and vascular growth in response to mechanical stretch

Background and Aims- Hypertension and obesity are important risk factors of cardiovascular disease. They are both associated with high leptin levels and have been shown to promote vascular hypertrophy, through the RhoA/ROCK and ERK1/2 phosphorylation. Calcineurin/NFAT activation also induces vascula...

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Bibliographic Details
Main Authors: Nadia Soudani, Crystal Malek Ghantous, Zein Farhat, Wassim Shebaby, Kazem Zibara, Asad Zeidan
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Physiology
Subjects:
Calcineurin
Hypertension
Hypertrophy
Leptin
NFAT
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00433/full

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