Fungi of the human gut microbiota: Roles and significance
It is becoming increasingly clear that fungi are important components of the gut microbiota. Fungi residing in the human intestine, for example, elicit the induction of T helper 17 cells, which are central orchestrators of protective immune responses. Likewise, fungal members of the intestinal micro...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-04-01
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| Series: | International Journal of Medical Microbiology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1438422121000199 |
| _version_ | 1829531477436530688 |
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| author | J. Christian Pérez |
| author_facet | J. Christian Pérez |
| author_sort | J. Christian Pérez |
| collection | DOAJ |
| description | It is becoming increasingly clear that fungi are important components of the gut microbiota. Fungi residing in the human intestine, for example, elicit the induction of T helper 17 cells, which are central orchestrators of protective immune responses. Likewise, fungal members of the intestinal microbiota have been shown to influence the immunological responses of the mammalian host by dampening or promoting local inflammatory responses. Here I review some of the latest developments regarding symbiotic fungi of the gastrointestinal tract and the consequences that fungal dysbiosis may have on human health. A major focus of the review is on the relationship between Candida albicans, the most prominent fungus inhabiting the human gut, and the mammalian host. Advances in the field underscore the need to further investigate the fungi that inhabit the human body to understand how the mixed array of microbes that constitute our microbiota contribute to health and disease. |
| first_indexed | 2024-12-16T18:22:10Z |
| format | Article |
| id | doaj.art-2011aa1dcafe43bbad7daae137d4f2d5 |
| institution | Directory Open Access Journal |
| issn | 1438-4221 |
| language | English |
| last_indexed | 2024-12-16T18:22:10Z |
| publishDate | 2021-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Medical Microbiology |
| spelling | doaj.art-2011aa1dcafe43bbad7daae137d4f2d52022-12-21T22:21:32ZengElsevierInternational Journal of Medical Microbiology1438-42212021-04-013113151490Fungi of the human gut microbiota: Roles and significanceJ. Christian Pérez0Interdisciplinary Center for Clinical Research, University Hospital Würzburg, Germany; Institute for Molecular Infection Biology, University Würzburg, Würzburg, Germany; Corresponding author. Current address at: Department of Microbiology and Molecular Genetics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, USA.It is becoming increasingly clear that fungi are important components of the gut microbiota. Fungi residing in the human intestine, for example, elicit the induction of T helper 17 cells, which are central orchestrators of protective immune responses. Likewise, fungal members of the intestinal microbiota have been shown to influence the immunological responses of the mammalian host by dampening or promoting local inflammatory responses. Here I review some of the latest developments regarding symbiotic fungi of the gastrointestinal tract and the consequences that fungal dysbiosis may have on human health. A major focus of the review is on the relationship between Candida albicans, the most prominent fungus inhabiting the human gut, and the mammalian host. Advances in the field underscore the need to further investigate the fungi that inhabit the human body to understand how the mixed array of microbes that constitute our microbiota contribute to health and disease.http://www.sciencedirect.com/science/article/pii/S1438422121000199FungiGut microbiotaCandida albicansInflammatory bowel disease |
| spellingShingle | J. Christian Pérez Fungi of the human gut microbiota: Roles and significance International Journal of Medical Microbiology Fungi Gut microbiota Candida albicans Inflammatory bowel disease |
| title | Fungi of the human gut microbiota: Roles and significance |
| title_full | Fungi of the human gut microbiota: Roles and significance |
| title_fullStr | Fungi of the human gut microbiota: Roles and significance |
| title_full_unstemmed | Fungi of the human gut microbiota: Roles and significance |
| title_short | Fungi of the human gut microbiota: Roles and significance |
| title_sort | fungi of the human gut microbiota roles and significance |
| topic | Fungi Gut microbiota Candida albicans Inflammatory bowel disease |
| url | http://www.sciencedirect.com/science/article/pii/S1438422121000199 |
| work_keys_str_mv | AT jchristianperez fungiofthehumangutmicrobiotarolesandsignificance |