Cooperation and Interplay between EGFR Signalling and Extracellular Vesicle Biogenesis in Cancer
Epidermal growth factor receptor (EGFR) takes centre stage in carcinogenesis throughout its entire cellular trafficking odyssey. When loaded in extracellular vesicles (EVs), EGFR is one of the key proteins involved in the transfer of information between parental cancer and bystander cells in the tum...
| Główni autorzy: | , , , , |
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| Format: | Artykuł |
| Język: | English |
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MDPI AG
2020-12-01
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| Seria: | Cells |
| Hasła przedmiotowe: | |
| Dostęp online: | https://www.mdpi.com/2073-4409/9/12/2639 |
| _version_ | 1827700525754220544 |
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| author | Laura C. Zanetti-Domingues Scott E. Bonner R. Sumanth Iyer Marisa L. Martin-Fernandez Veronica Huber |
| author_facet | Laura C. Zanetti-Domingues Scott E. Bonner R. Sumanth Iyer Marisa L. Martin-Fernandez Veronica Huber |
| author_sort | Laura C. Zanetti-Domingues |
| collection | DOAJ |
| description | Epidermal growth factor receptor (EGFR) takes centre stage in carcinogenesis throughout its entire cellular trafficking odyssey. When loaded in extracellular vesicles (EVs), EGFR is one of the key proteins involved in the transfer of information between parental cancer and bystander cells in the tumour microenvironment. To hijack EVs, EGFR needs to play multiple signalling roles in the life cycle of EVs. The receptor is involved in the biogenesis of specific EV subpopulations, it signals as an active cargo, and it can influence the uptake of EVs by recipient cells. EGFR regulates its own inclusion in EVs through feedback loops during disease progression and in response to challenges such as hypoxia, epithelial-to-mesenchymal transition and drugs. Here, we highlight how the spatiotemporal rules that regulate EGFR intracellular function intersect with and influence different EV biogenesis pathways and discuss key regulatory features and interactions of this interplay. We also elaborate on outstanding questions relating to EGFR-driven EV biogenesis and available methods to explore them. This mechanistic understanding will be key to unravelling the functional consequences of direct anti-EGFR targeted and indirect EGFR-impacting cancer therapies on the secretion of pro-tumoural EVs and on their effects on drug resistance and microenvironment subversion. |
| first_indexed | 2024-03-10T14:14:19Z |
| format | Article |
| id | doaj.art-20125efd15224f5dba91d7bfce3f9c6f |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T14:14:19Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-20125efd15224f5dba91d7bfce3f9c6f2023-11-20T23:54:43ZengMDPI AGCells2073-44092020-12-01912263910.3390/cells9122639Cooperation and Interplay between EGFR Signalling and Extracellular Vesicle Biogenesis in CancerLaura C. Zanetti-Domingues0Scott E. Bonner1R. Sumanth Iyer2Marisa L. Martin-Fernandez3Veronica Huber4Rutherford Appleton Laboratory, Central Laser Facility, Research Complex at Harwell, Didcot OX11 0FA, UKThe Wood Lab, Department of Paediatrics, University of Oxford, Oxford OX1 3QX, UKRutherford Appleton Laboratory, Central Laser Facility, Research Complex at Harwell, Didcot OX11 0FA, UKRutherford Appleton Laboratory, Central Laser Facility, Research Complex at Harwell, Didcot OX11 0FA, UKUnit of Immunotherapy of Human Tumors, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, ItalyEpidermal growth factor receptor (EGFR) takes centre stage in carcinogenesis throughout its entire cellular trafficking odyssey. When loaded in extracellular vesicles (EVs), EGFR is one of the key proteins involved in the transfer of information between parental cancer and bystander cells in the tumour microenvironment. To hijack EVs, EGFR needs to play multiple signalling roles in the life cycle of EVs. The receptor is involved in the biogenesis of specific EV subpopulations, it signals as an active cargo, and it can influence the uptake of EVs by recipient cells. EGFR regulates its own inclusion in EVs through feedback loops during disease progression and in response to challenges such as hypoxia, epithelial-to-mesenchymal transition and drugs. Here, we highlight how the spatiotemporal rules that regulate EGFR intracellular function intersect with and influence different EV biogenesis pathways and discuss key regulatory features and interactions of this interplay. We also elaborate on outstanding questions relating to EGFR-driven EV biogenesis and available methods to explore them. This mechanistic understanding will be key to unravelling the functional consequences of direct anti-EGFR targeted and indirect EGFR-impacting cancer therapies on the secretion of pro-tumoural EVs and on their effects on drug resistance and microenvironment subversion.https://www.mdpi.com/2073-4409/9/12/2639extracellular vesicles (EVs)EV biogenesisendocytosisEV heterogeneityMVB heterogeneityepidermal growth factor receptor (EGFR) |
| spellingShingle | Laura C. Zanetti-Domingues Scott E. Bonner R. Sumanth Iyer Marisa L. Martin-Fernandez Veronica Huber Cooperation and Interplay between EGFR Signalling and Extracellular Vesicle Biogenesis in Cancer Cells extracellular vesicles (EVs) EV biogenesis endocytosis EV heterogeneity MVB heterogeneity epidermal growth factor receptor (EGFR) |
| title | Cooperation and Interplay between EGFR Signalling and Extracellular Vesicle Biogenesis in Cancer |
| title_full | Cooperation and Interplay between EGFR Signalling and Extracellular Vesicle Biogenesis in Cancer |
| title_fullStr | Cooperation and Interplay between EGFR Signalling and Extracellular Vesicle Biogenesis in Cancer |
| title_full_unstemmed | Cooperation and Interplay between EGFR Signalling and Extracellular Vesicle Biogenesis in Cancer |
| title_short | Cooperation and Interplay between EGFR Signalling and Extracellular Vesicle Biogenesis in Cancer |
| title_sort | cooperation and interplay between egfr signalling and extracellular vesicle biogenesis in cancer |
| topic | extracellular vesicles (EVs) EV biogenesis endocytosis EV heterogeneity MVB heterogeneity epidermal growth factor receptor (EGFR) |
| url | https://www.mdpi.com/2073-4409/9/12/2639 |
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