Potential of Prebiotic Butyrogenic Fibers in Parkinson's Disease
Parkinson's Disease (PD) is a neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra. Recent evidence supports the involvement of the gastrointestinal tract in PD pathogenesis, including alterations in microbiota and intestinal permeability. Apart from...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-06-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2019.00663/full |
| _version_ | 1818032286211244032 |
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| author | Thaisa M. Cantu-Jungles Heather E. Rasmussen Bruce R. Hamaker |
| author_facet | Thaisa M. Cantu-Jungles Heather E. Rasmussen Bruce R. Hamaker |
| author_sort | Thaisa M. Cantu-Jungles |
| collection | DOAJ |
| description | Parkinson's Disease (PD) is a neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra. Recent evidence supports the involvement of the gastrointestinal tract in PD pathogenesis, including alterations in microbiota and intestinal permeability. Apart from being the preferred energy source for colonic epithelial cells, butyrate is involved in anti-inflammatory, enteroendocrine and epigenetic mechanisms that influence colonic and systemic health, including brain function. A few studies using oral administration of sodium butyrate indicate beneficial effects in PD animal models; however, prebiotic fibers that generate butyrate locally in the gut may be more effective. The design and selection of butyrogenic prebiotic fibers would allow preclinical studies to evaluate how gut-derived butyrate could affect PD pathophysiology. This review describes potential benefits of increasing gut butyrate production in PD through a prebiotic approach. Moreover, physico-chemical features of prebiotic fibers that target butyrogenic colonic bacteria are discussed. |
| first_indexed | 2024-12-10T06:04:57Z |
| format | Article |
| id | doaj.art-20133d834fc1454d8fcdf8839e7dc5db |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-10T06:04:57Z |
| publishDate | 2019-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-20133d834fc1454d8fcdf8839e7dc5db2022-12-22T01:59:43ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-06-011010.3389/fneur.2019.00663465766Potential of Prebiotic Butyrogenic Fibers in Parkinson's DiseaseThaisa M. Cantu-Jungles0Heather E. Rasmussen1Bruce R. Hamaker2Department of Food Science, Whistler Center for Carbohydrate Research, Purdue University, West Lafayette, IN, United StatesDepartment of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE, United StatesDepartment of Food Science, Whistler Center for Carbohydrate Research, Purdue University, West Lafayette, IN, United StatesParkinson's Disease (PD) is a neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra. Recent evidence supports the involvement of the gastrointestinal tract in PD pathogenesis, including alterations in microbiota and intestinal permeability. Apart from being the preferred energy source for colonic epithelial cells, butyrate is involved in anti-inflammatory, enteroendocrine and epigenetic mechanisms that influence colonic and systemic health, including brain function. A few studies using oral administration of sodium butyrate indicate beneficial effects in PD animal models; however, prebiotic fibers that generate butyrate locally in the gut may be more effective. The design and selection of butyrogenic prebiotic fibers would allow preclinical studies to evaluate how gut-derived butyrate could affect PD pathophysiology. This review describes potential benefits of increasing gut butyrate production in PD through a prebiotic approach. Moreover, physico-chemical features of prebiotic fibers that target butyrogenic colonic bacteria are discussed.https://www.frontiersin.org/article/10.3389/fneur.2019.00663/fulldietary fiberParkinson's diseasebutyrategut microbiotaprebiotics |
| spellingShingle | Thaisa M. Cantu-Jungles Heather E. Rasmussen Bruce R. Hamaker Potential of Prebiotic Butyrogenic Fibers in Parkinson's Disease Frontiers in Neurology dietary fiber Parkinson's disease butyrate gut microbiota prebiotics |
| title | Potential of Prebiotic Butyrogenic Fibers in Parkinson's Disease |
| title_full | Potential of Prebiotic Butyrogenic Fibers in Parkinson's Disease |
| title_fullStr | Potential of Prebiotic Butyrogenic Fibers in Parkinson's Disease |
| title_full_unstemmed | Potential of Prebiotic Butyrogenic Fibers in Parkinson's Disease |
| title_short | Potential of Prebiotic Butyrogenic Fibers in Parkinson's Disease |
| title_sort | potential of prebiotic butyrogenic fibers in parkinson s disease |
| topic | dietary fiber Parkinson's disease butyrate gut microbiota prebiotics |
| url | https://www.frontiersin.org/article/10.3389/fneur.2019.00663/full |
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