Telomere Length Is Correlated with Resting Metabolic Rate and Aerobic Capacity in Women: A Cross-Sectional Study
This study investigated the associations between relative telomere length (RTL) and resting metabolic rate (RMR), resting fat oxidation (RFO), and aerobic capacity and whether oxidative stress and inflammation are the underlying mechanisms in sedentary women. We also aimed to determine whether the c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/21/13336 |
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| author | Rujira Nonsa-ard Ploypailin Aneknan Terdthai Tong-un Sittisak Honsawek Chanvit Leelayuwat Naruemon Leelayuwat |
| author_facet | Rujira Nonsa-ard Ploypailin Aneknan Terdthai Tong-un Sittisak Honsawek Chanvit Leelayuwat Naruemon Leelayuwat |
| author_sort | Rujira Nonsa-ard |
| collection | DOAJ |
| description | This study investigated the associations between relative telomere length (RTL) and resting metabolic rate (RMR), resting fat oxidation (RFO), and aerobic capacity and whether oxidative stress and inflammation are the underlying mechanisms in sedentary women. We also aimed to determine whether the correlations depend on age and obesity. Sixty-eight normal weight and 66 obese women participated in this study. After adjustment for age, energy expenditure, energy intake, and education level, the RTL of all participants was negatively correlated with absolute RMR (RMR<sub>AB</sub>) and serum high-sensitivity C-reactive protein (hsCRP) concentration, and positively correlated with maximum oxygen consumption (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mover><mi>V</mi><mo>˙</mo></mover></mrow></semantics></math></inline-formula>O<sub>2max</sub>) (all <i>p</i> < 0.05). After additional adjustment for adiposity indices and fat-free mass (FFM), RTL was positively correlated with plasma vitamin C concentration (<i>p</i> < 0.05). Furthermore, after adjustment for fasting blood glucose concentration, RTL was negatively correlated with age and positively correlated with <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mover><mi>V</mi><mo>˙</mo></mover></mrow></semantics></math></inline-formula>O<sub>2max</sub> (mL/kg FFM/min). We found that normal weight women had longer RTL than obese women (<i>p</i> < 0.001). We suggest that RTL is negatively correlated with RMR<sub>AB</sub> and positively correlated with aerobic capacity, possibly via antioxidant and anti-inflammatory mechanisms. Furthermore, age and obesity influenced the associations. We provide useful information for the management of promotion strategies for health-related physical fitness in women. |
| first_indexed | 2024-03-09T19:00:19Z |
| format | Article |
| id | doaj.art-2015a2cf15e8445b852449f075e53a13 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T19:00:19Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2015a2cf15e8445b852449f075e53a132023-11-24T05:06:24ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123211333610.3390/ijms232113336Telomere Length Is Correlated with Resting Metabolic Rate and Aerobic Capacity in Women: A Cross-Sectional StudyRujira Nonsa-ard0Ploypailin Aneknan1Terdthai Tong-un2Sittisak Honsawek3Chanvit Leelayuwat4Naruemon Leelayuwat5Biomedical Sciences Program, Graduate School, Khon Kaen University, Khon Kaen 40002, ThailandExercise and Sport Sciences Development and Research Group, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandCentre of Excellence in Osteoarthritis and Musculoskeleton, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, ThailandCentre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002, ThailandExercise and Sport Sciences Development and Research Group, Khon Kaen University, Khon Kaen 40002, ThailandThis study investigated the associations between relative telomere length (RTL) and resting metabolic rate (RMR), resting fat oxidation (RFO), and aerobic capacity and whether oxidative stress and inflammation are the underlying mechanisms in sedentary women. We also aimed to determine whether the correlations depend on age and obesity. Sixty-eight normal weight and 66 obese women participated in this study. After adjustment for age, energy expenditure, energy intake, and education level, the RTL of all participants was negatively correlated with absolute RMR (RMR<sub>AB</sub>) and serum high-sensitivity C-reactive protein (hsCRP) concentration, and positively correlated with maximum oxygen consumption (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mover><mi>V</mi><mo>˙</mo></mover></mrow></semantics></math></inline-formula>O<sub>2max</sub>) (all <i>p</i> < 0.05). After additional adjustment for adiposity indices and fat-free mass (FFM), RTL was positively correlated with plasma vitamin C concentration (<i>p</i> < 0.05). Furthermore, after adjustment for fasting blood glucose concentration, RTL was negatively correlated with age and positively correlated with <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mover><mi>V</mi><mo>˙</mo></mover></mrow></semantics></math></inline-formula>O<sub>2max</sub> (mL/kg FFM/min). We found that normal weight women had longer RTL than obese women (<i>p</i> < 0.001). We suggest that RTL is negatively correlated with RMR<sub>AB</sub> and positively correlated with aerobic capacity, possibly via antioxidant and anti-inflammatory mechanisms. Furthermore, age and obesity influenced the associations. We provide useful information for the management of promotion strategies for health-related physical fitness in women.https://www.mdpi.com/1422-0067/23/21/13336telomere lengthmetabolismmaximum oxygen consumptionvitamin Chigh-sensitivity C-reactive protein |
| spellingShingle | Rujira Nonsa-ard Ploypailin Aneknan Terdthai Tong-un Sittisak Honsawek Chanvit Leelayuwat Naruemon Leelayuwat Telomere Length Is Correlated with Resting Metabolic Rate and Aerobic Capacity in Women: A Cross-Sectional Study International Journal of Molecular Sciences telomere length metabolism maximum oxygen consumption vitamin C high-sensitivity C-reactive protein |
| title | Telomere Length Is Correlated with Resting Metabolic Rate and Aerobic Capacity in Women: A Cross-Sectional Study |
| title_full | Telomere Length Is Correlated with Resting Metabolic Rate and Aerobic Capacity in Women: A Cross-Sectional Study |
| title_fullStr | Telomere Length Is Correlated with Resting Metabolic Rate and Aerobic Capacity in Women: A Cross-Sectional Study |
| title_full_unstemmed | Telomere Length Is Correlated with Resting Metabolic Rate and Aerobic Capacity in Women: A Cross-Sectional Study |
| title_short | Telomere Length Is Correlated with Resting Metabolic Rate and Aerobic Capacity in Women: A Cross-Sectional Study |
| title_sort | telomere length is correlated with resting metabolic rate and aerobic capacity in women a cross sectional study |
| topic | telomere length metabolism maximum oxygen consumption vitamin C high-sensitivity C-reactive protein |
| url | https://www.mdpi.com/1422-0067/23/21/13336 |
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