IFN-<FONT FACE=Symbol>g</font> in human Chagas' disease: protection or pathology?
An apparently paradoxical role for IFN-<FONT FACE="Symbol">g</font> in human Chagas' disease was observed when studying the pattern of cytokine production by peripheral blood mononuclear cells (PBMC) obtained from two groups of chagasic patients after specific stimulation...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
1998-01-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100017 |
| _version_ | 1819294346668670976 |
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| author | L.M.G. Bahia-Oliveira J.A.S. Gomes M.O.C. Rocha M.C.V. Moreira E.M. Lemos Z.M.P. Luz M.E.S. Pereira R.L. Coffman J.C.P. Dias J.R. Cançado G. Gazzinelli R. Corrêa-Oliveira |
| author_facet | L.M.G. Bahia-Oliveira J.A.S. Gomes M.O.C. Rocha M.C.V. Moreira E.M. Lemos Z.M.P. Luz M.E.S. Pereira R.L. Coffman J.C.P. Dias J.R. Cançado G. Gazzinelli R. Corrêa-Oliveira |
| author_sort | L.M.G. Bahia-Oliveira |
| collection | DOAJ |
| description | An apparently paradoxical role for IFN-<FONT FACE="Symbol">g</font> in human Chagas' disease was observed when studying the pattern of cytokine production by peripheral blood mononuclear cells (PBMC) obtained from two groups of chagasic patients after specific stimulation with Trypanosoma cruzi-derived antigens. The groups studied were 1) patients treated with benznidazole during the acute phase of Trypanosoma cruzi infection and 2) chronically infected untreated patients. In the treated group, higher levels of IFN-<FONT FACE="Symbol">g</font> were produced by PBMC from individuals cured after treatment when compared to non-cured patients. In contrast, in the chronically infected group (not treated) higher levels of IFN-<FONT FACE="Symbol">g</font> were produced by PBMC from cardiac patients in comparison with asymptomatic (indeterminate) patients. This apparently paradoxical role for IFN-<FONT FACE="Symbol">g</font> in human Chagas' disease is discussed in terms of the possibility of a temporal difference in IFN-<FONT FACE="Symbol">g</font> production during the initial stages of the infection (acute phase) in the presence or absence of chemotherapy. The maintenance of an immune response with high levels of IFN-<FONT FACE="Symbol">g</font> production during the chronic phase of the infection may favor cure or influence the development of the cardiac form of the disease |
| first_indexed | 2024-12-24T04:24:52Z |
| format | Article |
| id | doaj.art-20165cab277a4647bf135927620dbf0f |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-24T04:24:52Z |
| publishDate | 1998-01-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-20165cab277a4647bf135927620dbf0f2022-12-21T17:15:40ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X1998-01-0131112710.1590/S0100-879X1998000100017IFN-<FONT FACE=Symbol>g</font> in human Chagas' disease: protection or pathology?L.M.G. Bahia-OliveiraJ.A.S. GomesM.O.C. RochaM.C.V. MoreiraE.M. LemosZ.M.P. LuzM.E.S. PereiraR.L. CoffmanJ.C.P. DiasJ.R. CançadoG. GazzinelliR. Corrêa-OliveiraAn apparently paradoxical role for IFN-<FONT FACE="Symbol">g</font> in human Chagas' disease was observed when studying the pattern of cytokine production by peripheral blood mononuclear cells (PBMC) obtained from two groups of chagasic patients after specific stimulation with Trypanosoma cruzi-derived antigens. The groups studied were 1) patients treated with benznidazole during the acute phase of Trypanosoma cruzi infection and 2) chronically infected untreated patients. In the treated group, higher levels of IFN-<FONT FACE="Symbol">g</font> were produced by PBMC from individuals cured after treatment when compared to non-cured patients. In contrast, in the chronically infected group (not treated) higher levels of IFN-<FONT FACE="Symbol">g</font> were produced by PBMC from cardiac patients in comparison with asymptomatic (indeterminate) patients. This apparently paradoxical role for IFN-<FONT FACE="Symbol">g</font> in human Chagas' disease is discussed in terms of the possibility of a temporal difference in IFN-<FONT FACE="Symbol">g</font> production during the initial stages of the infection (acute phase) in the presence or absence of chemotherapy. The maintenance of an immune response with high levels of IFN-<FONT FACE="Symbol">g</font> production during the chronic phase of the infection may favor cure or influence the development of the cardiac form of the diseasehttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100017Trypanosoma cruziChagas' diseasecardiomyopathyperipheral blood mononuclear cells (PBMC)cytokinesINF-<FONT FACE=Symbol>g</font> |
| spellingShingle | L.M.G. Bahia-Oliveira J.A.S. Gomes M.O.C. Rocha M.C.V. Moreira E.M. Lemos Z.M.P. Luz M.E.S. Pereira R.L. Coffman J.C.P. Dias J.R. Cançado G. Gazzinelli R. Corrêa-Oliveira IFN-<FONT FACE=Symbol>g</font> in human Chagas' disease: protection or pathology? Brazilian Journal of Medical and Biological Research Trypanosoma cruzi Chagas' disease cardiomyopathy peripheral blood mononuclear cells (PBMC) cytokines INF-<FONT FACE=Symbol>g</font> |
| title | IFN-<FONT FACE=Symbol>g</font> in human Chagas' disease: protection or pathology? |
| title_full | IFN-<FONT FACE=Symbol>g</font> in human Chagas' disease: protection or pathology? |
| title_fullStr | IFN-<FONT FACE=Symbol>g</font> in human Chagas' disease: protection or pathology? |
| title_full_unstemmed | IFN-<FONT FACE=Symbol>g</font> in human Chagas' disease: protection or pathology? |
| title_short | IFN-<FONT FACE=Symbol>g</font> in human Chagas' disease: protection or pathology? |
| title_sort | ifn font face symbol g font in human chagas disease protection or pathology |
| topic | Trypanosoma cruzi Chagas' disease cardiomyopathy peripheral blood mononuclear cells (PBMC) cytokines INF-<FONT FACE=Symbol>g</font> |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100017 |
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