Establishment, optimization and validation of a fluorescence polarization-based high-throughput screening assay targeting cathepsin L inhibitors

Establishment, optimization and validation of a fluorescence polarization-based high-throughput screening assay targeting cathepsin L inhibitors

Cathepsin L (CTSL), a lysosomal cysteine proteinase, is primarily dedicated to the metabolic turnover of intracellular proteins. It is involved in various physiological processes and contributes to pathological conditions such as viral infection, tumor invasion and metastasis, inflammatory status, a...

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Bibliographic Details
Main Authors: Wenwen Zhou, Baoqing You, Xiaomeng Zhao, Shuyi Si, Yan Li, Jing Zhang
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:SLAS Discovery
Subjects:
Cathepsin L
Severe acute respiratory syndrome coronavirus 2
Fluorescence polarization
High-throughput screening
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555224000157

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