Human papillomavirus-16 presence and physical status in lung carcinomas from Asia
<p>Abstract</p> <p>Background</p> <p>Although human papillomavirus (HPV) genome has been detected in lung cancer, its prevalence is highly variable around the world. Higher frequencies have been reported in far-east Asian countries, when compared with European countries...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-11-01
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| Series: | Infectious Agents and Cancer |
| Online Access: | http://www.infectagentscancer.com/content/5/1/20 |
| _version_ | 1828255535089057792 |
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| author | Morewaya Jacob Sun Quanfu Castillo Andres Koriyama Chihaya Anwar Muhammad Aguayo Francisco Eizuru Yoshito Akiba Suminori |
| author_facet | Morewaya Jacob Sun Quanfu Castillo Andres Koriyama Chihaya Anwar Muhammad Aguayo Francisco Eizuru Yoshito Akiba Suminori |
| author_sort | Morewaya Jacob |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Although human papillomavirus (HPV) genome has been detected in lung cancer, its prevalence is highly variable around the world. Higher frequencies have been reported in far-east Asian countries, when compared with European countries. The present study analysed the HPV-16 presence in 60 lung carcinomas from the Asian countries China, Pakistan and Papua New Guinea.</p> <p>Results</p> <p>HPV-16 was present in 8/59 (13%) samples. According to histological type, HPV-16 was detected in 8/18 (44%) squamous cell carcinomas (SQCs), which were mainly from Pakistan; 0/38 (0%) adenocarcinomas (ACs), which were mainly from China; and in 0/4 (0%) small cell carcinomas (SCLCs). The observed histological difference was statistically significant (p < 0.001). HPV-16 viral load was also determined using real-time polymerase chain reaction (qRT-PCR); it ranged between 411 to 2345 copies/100 ng of genomic DNA. HPV-16 genome was found integrated into the host genome in every HPV-16 positive carcinoma.</p> <p>Conclusion</p> <p>These results support the notion that HPV-16 infection is highly associated with SQCs in Pakistan. Our results show a frequent HPV-16 integration in SQCs, although the low viral load casts doubt respect a direct etiological role of HPV in lung carcinomas from Asia. Additional HPV-16 characterization is necessary to establish a direct or indirect etiological role of HPV in this malignancy.</p> |
| first_indexed | 2024-04-13T02:15:34Z |
| format | Article |
| id | doaj.art-20180aa597df4d3eacf5f2f7a192904a |
| institution | Directory Open Access Journal |
| issn | 1750-9378 |
| language | English |
| last_indexed | 2024-04-13T02:15:34Z |
| publishDate | 2010-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Infectious Agents and Cancer |
| spelling | doaj.art-20180aa597df4d3eacf5f2f7a192904a2022-12-22T03:07:10ZengBMCInfectious Agents and Cancer1750-93782010-11-01512010.1186/1750-9378-5-20Human papillomavirus-16 presence and physical status in lung carcinomas from AsiaMorewaya JacobSun QuanfuCastillo AndresKoriyama ChihayaAnwar MuhammadAguayo FranciscoEizuru YoshitoAkiba Suminori<p>Abstract</p> <p>Background</p> <p>Although human papillomavirus (HPV) genome has been detected in lung cancer, its prevalence is highly variable around the world. Higher frequencies have been reported in far-east Asian countries, when compared with European countries. The present study analysed the HPV-16 presence in 60 lung carcinomas from the Asian countries China, Pakistan and Papua New Guinea.</p> <p>Results</p> <p>HPV-16 was present in 8/59 (13%) samples. According to histological type, HPV-16 was detected in 8/18 (44%) squamous cell carcinomas (SQCs), which were mainly from Pakistan; 0/38 (0%) adenocarcinomas (ACs), which were mainly from China; and in 0/4 (0%) small cell carcinomas (SCLCs). The observed histological difference was statistically significant (p < 0.001). HPV-16 viral load was also determined using real-time polymerase chain reaction (qRT-PCR); it ranged between 411 to 2345 copies/100 ng of genomic DNA. HPV-16 genome was found integrated into the host genome in every HPV-16 positive carcinoma.</p> <p>Conclusion</p> <p>These results support the notion that HPV-16 infection is highly associated with SQCs in Pakistan. Our results show a frequent HPV-16 integration in SQCs, although the low viral load casts doubt respect a direct etiological role of HPV in lung carcinomas from Asia. Additional HPV-16 characterization is necessary to establish a direct or indirect etiological role of HPV in this malignancy.</p>http://www.infectagentscancer.com/content/5/1/20 |
| spellingShingle | Morewaya Jacob Sun Quanfu Castillo Andres Koriyama Chihaya Anwar Muhammad Aguayo Francisco Eizuru Yoshito Akiba Suminori Human papillomavirus-16 presence and physical status in lung carcinomas from Asia Infectious Agents and Cancer |
| title | Human papillomavirus-16 presence and physical status in lung carcinomas from Asia |
| title_full | Human papillomavirus-16 presence and physical status in lung carcinomas from Asia |
| title_fullStr | Human papillomavirus-16 presence and physical status in lung carcinomas from Asia |
| title_full_unstemmed | Human papillomavirus-16 presence and physical status in lung carcinomas from Asia |
| title_short | Human papillomavirus-16 presence and physical status in lung carcinomas from Asia |
| title_sort | human papillomavirus 16 presence and physical status in lung carcinomas from asia |
| url | http://www.infectagentscancer.com/content/5/1/20 |
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