USP9x promotes CD8 <sup>+</sup> T-cell dysfunction in association with autophagy inhibition in septic liver injury

USP9x promotes CD8 <sup>+</sup> T-cell dysfunction in association with autophagy inhibition in septic liver injury

Sepsis is a life-threatening condition manifested by concurrent inflammation and immunosuppression. Ubiquitin-specific peptidase 9, X-linked (USP9x), is a USP domain-containing deubiquitinase which is required in T-cell development. In the present study, we investigate whether USP9x plays a role in...

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Bibliographic Details
Main Authors: Sheng Lulu, Chen Juntao, Tong Yiqing, Zhang Yi, Feng Qiming, Tang Zhenghao
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2022-11-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
sepsis
liver injury
USP9x
CD8 <sup>+</sup> T cells
autophagy
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2022174

Internet

https://www.sciengine.com/doi/10.3724/abbs.2022174

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