Novel ruthenium(ii) N-heterocyclic carbene complexes: Synthesis, characterization, and evaluation of their biological activities
A series of ruthenium(ii) complexes with N-heterocyclic carbene (NHC) ligands of the general type (arene)(NHC)Ru(ii)X2 (where X = halide) (3a–3d) were synthesized and characterized in order to compare their antibacterial activities with benzimidazolium salts 2. Our comparison revealed that ruthenium...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2023-11-01
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| Series: | Main Group Metal Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/mgmc-2023-0008 |
| _version_ | 1797435641009537024 |
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| author | Jawhari Ahmed Hussain Amri Nasser Mukhrish Yousef E. Gatri Rafik Özdemir Ismail Gürbüz Nevin Mansour Lamjed Koko Waleed S. Hamdi Naceur |
| author_facet | Jawhari Ahmed Hussain Amri Nasser Mukhrish Yousef E. Gatri Rafik Özdemir Ismail Gürbüz Nevin Mansour Lamjed Koko Waleed S. Hamdi Naceur |
| author_sort | Jawhari Ahmed Hussain |
| collection | DOAJ |
| description | A series of ruthenium(ii) complexes with N-heterocyclic carbene (NHC) ligands of the general type (arene)(NHC)Ru(ii)X2 (where X = halide) (3a–3d) were synthesized and characterized in order to compare their antibacterial activities with benzimidazolium salts 2. Our comparison revealed that ruthenium(ii) NHC complexes 3 were more active than benzimidazolium salts 2. Furthermore, the two complexes 3b and 3d had a potent inhibitory effect against acetylcholinesterase with an IC50 of 4.52 and 4.04 g·mL−1 and against tyrosinase with an IC50 of 20.77 and 25.84 g·mL−1, respectively. In addition, screening of benzimidazolium salts (2a–2d) and their ruthenium(ii) complexes (3a–3d) against colon carcinoma cell lines (HCT-116) and hepatocellular carcinoma cell lines (HepG-2) were studied. The obtained results revealed that complex 3a is the most active against vinblastines. |
| first_indexed | 2024-03-09T10:51:10Z |
| format | Article |
| id | doaj.art-201a0f4d634b448481cc25f7ace0f374 |
| institution | Directory Open Access Journal |
| issn | 2191-0219 |
| language | English |
| last_indexed | 2024-03-09T10:51:10Z |
| publishDate | 2023-11-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Main Group Metal Chemistry |
| spelling | doaj.art-201a0f4d634b448481cc25f7ace0f3742023-12-01T07:18:48ZengDe GruyterMain Group Metal Chemistry2191-02192023-11-014611046104910.1515/mgmc-2023-0008Novel ruthenium(ii) N-heterocyclic carbene complexes: Synthesis, characterization, and evaluation of their biological activitiesJawhari Ahmed Hussain0Amri Nasser1Mukhrish Yousef E.2Gatri Rafik3Özdemir Ismail4Gürbüz Nevin5Mansour Lamjed6Koko Waleed S.7Hamdi Naceur8Department of Chemistry, Faculty of Science, Jazan University, P.O. Box 2097, Jazan45142, Saudi ArabiaDepartment of Chemistry, Faculty of Science, Jazan University, P.O. Box 2097, Jazan45142, Saudi ArabiaDepartment of Chemistry, Faculty of Science, Jazan University, P.O. Box 2097, Jazan45142, Saudi ArabiaLaboratoire de Synthèse Organique Sélective et Hétérocyclique Évaluation Biologique LR17ES01 Faculté des Sciences de Tunis Faculté des Sciences de Tunis Campus Universitaire, Université de Tunis El Manar, 1092Tunis, Tunisiaİnönü University, Catalysis Research and Application Center, 44280Malatya, Turkeyİnönü University, Catalysis Research and Application Center, 44280Malatya, TurkeyZoology Department, College of Science, King Saud University, Saudi Arabia, P.O. Box 2455, Riyadh11451, Saudi ArabiaDepartment of Science Laboratories, College of Science and Arts, Qassim University, Ar Rass51921, Saudi ArabiaResearch Laboratory of Environmental Sciences and Technologies (LR16ES09), Higher Institute of Environmental Sciences and Technology, University of Carthage, Hammam-Lif, TunisiaA series of ruthenium(ii) complexes with N-heterocyclic carbene (NHC) ligands of the general type (arene)(NHC)Ru(ii)X2 (where X = halide) (3a–3d) were synthesized and characterized in order to compare their antibacterial activities with benzimidazolium salts 2. Our comparison revealed that ruthenium(ii) NHC complexes 3 were more active than benzimidazolium salts 2. Furthermore, the two complexes 3b and 3d had a potent inhibitory effect against acetylcholinesterase with an IC50 of 4.52 and 4.04 g·mL−1 and against tyrosinase with an IC50 of 20.77 and 25.84 g·mL−1, respectively. In addition, screening of benzimidazolium salts (2a–2d) and their ruthenium(ii) complexes (3a–3d) against colon carcinoma cell lines (HCT-116) and hepatocellular carcinoma cell lines (HepG-2) were studied. The obtained results revealed that complex 3a is the most active against vinblastines.https://doi.org/10.1515/mgmc-2023-0008biological activitybenzimidazolium saltsruthenium complexessilver complexeshct-116hepg-2 |
| spellingShingle | Jawhari Ahmed Hussain Amri Nasser Mukhrish Yousef E. Gatri Rafik Özdemir Ismail Gürbüz Nevin Mansour Lamjed Koko Waleed S. Hamdi Naceur Novel ruthenium(ii) N-heterocyclic carbene complexes: Synthesis, characterization, and evaluation of their biological activities Main Group Metal Chemistry biological activity benzimidazolium salts ruthenium complexes silver complexes hct-116 hepg-2 |
| title | Novel ruthenium(ii) N-heterocyclic carbene complexes: Synthesis, characterization, and evaluation of their biological activities |
| title_full | Novel ruthenium(ii) N-heterocyclic carbene complexes: Synthesis, characterization, and evaluation of their biological activities |
| title_fullStr | Novel ruthenium(ii) N-heterocyclic carbene complexes: Synthesis, characterization, and evaluation of their biological activities |
| title_full_unstemmed | Novel ruthenium(ii) N-heterocyclic carbene complexes: Synthesis, characterization, and evaluation of their biological activities |
| title_short | Novel ruthenium(ii) N-heterocyclic carbene complexes: Synthesis, characterization, and evaluation of their biological activities |
| title_sort | novel ruthenium ii n heterocyclic carbene complexes synthesis characterization and evaluation of their biological activities |
| topic | biological activity benzimidazolium salts ruthenium complexes silver complexes hct-116 hepg-2 |
| url | https://doi.org/10.1515/mgmc-2023-0008 |
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