Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation

Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation

Abstract Background The three-dimensional genome organization is critical for gene regulation and can malfunction in diseases like cancer. As a key regulator of genome organization, CCCTC-binding factor (CTCF) has been characterized as a DNA-binding protein with important functions in maintaining th...

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Bibliographic Details
Main Authors: Celestia Fang, Zhenjia Wang, Cuijuan Han, Stephanie L. Safgren, Kathryn A. Helmin, Emmalee R. Adelman, Valentina Serafin, Giuseppe Basso, Kyle P. Eagen, Alexandre Gaspar-Maia, Maria E. Figueroa, Benjamin D. Singer, Aakrosh Ratan, Panagiotis Ntziachristos, Chongzhi Zang
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Genome Biology
Subjects:
CTCF
3D genome organization
Integrative analysis
Gene regulation
Transcription factor
Enhancer
Online Access:http://link.springer.com/article/10.1186/s13059-020-02152-7

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