Knockdown of CD44 inhibits proliferation, migration and invasion of osteosarcoma cells accompanied by downregulation of cathepsin S

Knockdown of CD44 inhibits proliferation, migration and invasion of osteosarcoma cells accompanied by downregulation of cathepsin S

Abstract Background Osteosarcoma (OS) is a malignant bone tumour of mesenchymal origin. These tumours are characterised by rich vascularisation, therefore promoting rapid proliferation and facilitating metastasis. CD44 has been reported to be involved in OS, but its role and molecular mechanisms in...

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Bibliographic Details
Main Authors: Lingwei Kong, Hairu Ji, Xintian Gan, Sheng Cao, Zhehong Li, Yu Jin
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Osteosarcoma
CD44
Cathepsin S
Proliferation
Migration
Invasion
Online Access:https://doi.org/10.1186/s13018-022-03048-x

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