STRESS-RESPONSE TO RADICAL SURGERIES FOR GASTRIC CANCER
The purpose of the study was to evaluate the anesthetic effect of the combination of xenon and dexmedetomidine during surgery for gastric cancer. Material and methods. The prospective randomized study included 53 patients with operable II–III stage gastric cancer. The age range was from 26 to 75 yea...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2017-12-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/638 |
| _version_ | 1797875843113943040 |
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| author | S. V. Avdeev S. G. Afanasyev V. V. Faltin K. V. Shalygina L. V. Gerdt |
| author_facet | S. V. Avdeev S. G. Afanasyev V. V. Faltin K. V. Shalygina L. V. Gerdt |
| author_sort | S. V. Avdeev |
| collection | DOAJ |
| description | The purpose of the study was to evaluate the anesthetic effect of the combination of xenon and dexmedetomidine during surgery for gastric cancer. Material and methods. The prospective randomized study included 53 patients with operable II–III stage gastric cancer. The age range was from 26 to 75 years. The patients underwent gastrectomy (n=21) and subtotal distal gastrectomy (n=32). The study group comprised 27 patients who received anesthesia with xenon and dexmedetomidine combined with epidural analgesia. The control group consisted of 26 patients who received anesthesia with sevoflurane in combination with epidural analgesia. Intraoperative patient monitoring was performed according to Harvard intraoperative monitoring standards. Plasma levels of ACTH, STH cortisole, IL-1β, IL-6, and CRP as well as cytokine profile were used to evaluate the effect of two anesthetic methods. Results. In the perioperative period, the combination of xenon and dexmedetomidine in combination with epidural analgesia was characterized by significant inhibition of systemic inflammatory reactions and a lower release of stress hormones as components of a surgical stress response expressed by a lower level of pro-inflammatory cytokines and somatotropic hormone. The frequency of postoperative inflammatory complications was lower in the xenon group than in the control group. Conclusion. The use of the combination of xenon and dexmedetomidine during surgery for gastric cancer provides a more adequate course of the perioperative period. |
| first_indexed | 2024-04-10T01:52:59Z |
| format | Article |
| id | doaj.art-201b5efe2b6341af900433625e16b2c5 |
| institution | Directory Open Access Journal |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| last_indexed | 2024-04-10T01:52:59Z |
| publishDate | 2017-12-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj.art-201b5efe2b6341af900433625e16b2c52023-03-13T09:05:50ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682017-12-01166253010.21294/1814-4861-2017-16-6-25-30495STRESS-RESPONSE TO RADICAL SURGERIES FOR GASTRIC CANCERS. V. Avdeev0S. G. Afanasyev1V. V. Faltin2K. V. Shalygina3L. V. Gerdt4Научно-исследовательский институт онкологии, Томский национальный исследовательский медицинский центр Российской академии наук, г. ТомскНаучно-исследовательский институт онкологии, Томский национальный исследовательский медицинский центр Российской академии наук, г. ТомскНаучно-исследовательский институт онкологии, Томский национальный исследовательский медицинский центр Российской академии наук, г. ТомскНаучно-исследовательский институт онкологии, Томский национальный исследовательский медицинский центр Российской академии наук, г. ТомскНаучно-исследовательский институт онкологии, Томский национальный исследовательский медицинский центр Российской академии наук, г. ТомскThe purpose of the study was to evaluate the anesthetic effect of the combination of xenon and dexmedetomidine during surgery for gastric cancer. Material and methods. The prospective randomized study included 53 patients with operable II–III stage gastric cancer. The age range was from 26 to 75 years. The patients underwent gastrectomy (n=21) and subtotal distal gastrectomy (n=32). The study group comprised 27 patients who received anesthesia with xenon and dexmedetomidine combined with epidural analgesia. The control group consisted of 26 patients who received anesthesia with sevoflurane in combination with epidural analgesia. Intraoperative patient monitoring was performed according to Harvard intraoperative monitoring standards. Plasma levels of ACTH, STH cortisole, IL-1β, IL-6, and CRP as well as cytokine profile were used to evaluate the effect of two anesthetic methods. Results. In the perioperative period, the combination of xenon and dexmedetomidine in combination with epidural analgesia was characterized by significant inhibition of systemic inflammatory reactions and a lower release of stress hormones as components of a surgical stress response expressed by a lower level of pro-inflammatory cytokines and somatotropic hormone. The frequency of postoperative inflammatory complications was lower in the xenon group than in the control group. Conclusion. The use of the combination of xenon and dexmedetomidine during surgery for gastric cancer provides a more adequate course of the perioperative period.https://www.siboncoj.ru/jour/article/view/638рак желудкамультимодальная анестезияксенондексмедетомидиноперативное лечениепериоперационный периодгормональный и цитокиновый профиль |
| spellingShingle | S. V. Avdeev S. G. Afanasyev V. V. Faltin K. V. Shalygina L. V. Gerdt STRESS-RESPONSE TO RADICAL SURGERIES FOR GASTRIC CANCER Сибирский онкологический журнал рак желудка мультимодальная анестезия ксенон дексмедетомидин оперативное лечение периоперационный период гормональный и цитокиновый профиль |
| title | STRESS-RESPONSE TO RADICAL SURGERIES FOR GASTRIC CANCER |
| title_full | STRESS-RESPONSE TO RADICAL SURGERIES FOR GASTRIC CANCER |
| title_fullStr | STRESS-RESPONSE TO RADICAL SURGERIES FOR GASTRIC CANCER |
| title_full_unstemmed | STRESS-RESPONSE TO RADICAL SURGERIES FOR GASTRIC CANCER |
| title_short | STRESS-RESPONSE TO RADICAL SURGERIES FOR GASTRIC CANCER |
| title_sort | stress response to radical surgeries for gastric cancer |
| topic | рак желудка мультимодальная анестезия ксенон дексмедетомидин оперативное лечение периоперационный период гормональный и цитокиновый профиль |
| url | https://www.siboncoj.ru/jour/article/view/638 |
| work_keys_str_mv | AT svavdeev stressresponsetoradicalsurgeriesforgastriccancer AT sgafanasyev stressresponsetoradicalsurgeriesforgastriccancer AT vvfaltin stressresponsetoradicalsurgeriesforgastriccancer AT kvshalygina stressresponsetoradicalsurgeriesforgastriccancer AT lvgerdt stressresponsetoradicalsurgeriesforgastriccancer |