Heterogeneity of psychosocial functioning in patients with bipolar disorder: Associations with sociodemographic, clinical, neurocognitive and biochemical variables
ObjectiveThis study aims to identify the functional heterogeneity in fully or partially remitted patients with bipolar disorder and explore the correlations between psychosocial functioning and sociodemographic, clinical, neurocognitive and biochemical variables.MethodsOne hundred and forty fully or...
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| Format: | Article |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.900757/full |
| _version_ | 1811266335574851584 |
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| author | Zhengling Ba Minhua Chen Jiulan Lai Yingtao Liao Hengying Fang Dali Lu Yingjun Zheng Kunlun Zong Xiaoling Lin |
| author_facet | Zhengling Ba Minhua Chen Jiulan Lai Yingtao Liao Hengying Fang Dali Lu Yingjun Zheng Kunlun Zong Xiaoling Lin |
| author_sort | Zhengling Ba |
| collection | DOAJ |
| description | ObjectiveThis study aims to identify the functional heterogeneity in fully or partially remitted patients with bipolar disorder and explore the correlations between psychosocial functioning and sociodemographic, clinical, neurocognitive and biochemical variables.MethodsOne hundred and forty fully or partially remitted patients with bipolar disorder (BD) and seventy healthy controls were recruited. The patients were grouped into different profiles based on the Functioning Assessment Short Test (FAST) domain scores by hierarchical cluster analysis. The characteristics of subgroups and the correlations between psychosocial functioning and sociodemographic, clinical, neurocognitive and biochemical variables in each cluster were then analyzed.ResultsThere were three subgroups in fully or partially remitted patients with BD: the lower functioning group (LF), performed global functioning impairments; the moderate functioning group (MF), presented selective impairments in functional domains; and the good functioning subgroup (GF), performed almost intact functioning. Among the three subgroups, there were differences in FAST domains, sociodemographic variables, clinical variables, some neurocognitive domains and several biochemical indexes.ConclusionsThe study successfully identified three functional subgroups. The characteristics of discrete subgroups and the specific clinical factors, neurocognitive domains and biochemical indexes that are correlated with functional subgroups will allow for making tailored interventions to promote functional recovery and improve the quality of life. |
| first_indexed | 2024-04-12T20:40:07Z |
| format | Article |
| id | doaj.art-201bdfc7aa0847ec965a08f4f98825bf |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-12T20:40:07Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-201bdfc7aa0847ec965a08f4f98825bf2022-12-22T03:17:25ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-09-011310.3389/fpsyt.2022.900757900757Heterogeneity of psychosocial functioning in patients with bipolar disorder: Associations with sociodemographic, clinical, neurocognitive and biochemical variablesZhengling Ba0Minhua Chen1Jiulan Lai2Yingtao Liao3Hengying Fang4Dali Lu5Yingjun Zheng6Kunlun Zong7Xiaoling Lin8School of Nursing, Sun Yat-sen University, Guangzhou, ChinaDepartment of Psychiatry, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, ChinaSchool of Nursing, Sun Yat-sen University, Guangzhou, ChinaDepartment of Psychiatry, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, ChinaDepartment of Psychiatry, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, ChinaDepartment of Psychiatry, Xiamen Xianyue Hospital, Xiamen, ChinaDepartment of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, ChinaDepartment of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, ChinaSchool of Nursing, Sun Yat-sen University, Guangzhou, ChinaObjectiveThis study aims to identify the functional heterogeneity in fully or partially remitted patients with bipolar disorder and explore the correlations between psychosocial functioning and sociodemographic, clinical, neurocognitive and biochemical variables.MethodsOne hundred and forty fully or partially remitted patients with bipolar disorder (BD) and seventy healthy controls were recruited. The patients were grouped into different profiles based on the Functioning Assessment Short Test (FAST) domain scores by hierarchical cluster analysis. The characteristics of subgroups and the correlations between psychosocial functioning and sociodemographic, clinical, neurocognitive and biochemical variables in each cluster were then analyzed.ResultsThere were three subgroups in fully or partially remitted patients with BD: the lower functioning group (LF), performed global functioning impairments; the moderate functioning group (MF), presented selective impairments in functional domains; and the good functioning subgroup (GF), performed almost intact functioning. Among the three subgroups, there were differences in FAST domains, sociodemographic variables, clinical variables, some neurocognitive domains and several biochemical indexes.ConclusionsThe study successfully identified three functional subgroups. The characteristics of discrete subgroups and the specific clinical factors, neurocognitive domains and biochemical indexes that are correlated with functional subgroups will allow for making tailored interventions to promote functional recovery and improve the quality of life.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.900757/fullbipolar disorderpsychosocial functioningneurocognitionbiochemical indexcluster analysis |
| spellingShingle | Zhengling Ba Minhua Chen Jiulan Lai Yingtao Liao Hengying Fang Dali Lu Yingjun Zheng Kunlun Zong Xiaoling Lin Heterogeneity of psychosocial functioning in patients with bipolar disorder: Associations with sociodemographic, clinical, neurocognitive and biochemical variables Frontiers in Psychiatry bipolar disorder psychosocial functioning neurocognition biochemical index cluster analysis |
| title | Heterogeneity of psychosocial functioning in patients with bipolar disorder: Associations with sociodemographic, clinical, neurocognitive and biochemical variables |
| title_full | Heterogeneity of psychosocial functioning in patients with bipolar disorder: Associations with sociodemographic, clinical, neurocognitive and biochemical variables |
| title_fullStr | Heterogeneity of psychosocial functioning in patients with bipolar disorder: Associations with sociodemographic, clinical, neurocognitive and biochemical variables |
| title_full_unstemmed | Heterogeneity of psychosocial functioning in patients with bipolar disorder: Associations with sociodemographic, clinical, neurocognitive and biochemical variables |
| title_short | Heterogeneity of psychosocial functioning in patients with bipolar disorder: Associations with sociodemographic, clinical, neurocognitive and biochemical variables |
| title_sort | heterogeneity of psychosocial functioning in patients with bipolar disorder associations with sociodemographic clinical neurocognitive and biochemical variables |
| topic | bipolar disorder psychosocial functioning neurocognition biochemical index cluster analysis |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.900757/full |
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