Using the <i>PEAR1</i> Polymorphisms Rs12041331 and Rs2768759 as Potential Predictive Markers of 90-Day Bleeding Events in the Context of Minor Strokes and Transient Ischemic Attack
In this study, we explored the relationship between the platelet endothelial aggregation receptor 1 (<i>PEAR1</i>) polymorphisms, platelet reactivity, and clinical outcomes in patients with minor stroke or transient ischemic attack (TIA). Randomized controlled trial subgroups were assess...
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| Format: | Article |
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MDPI AG
2023-09-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/10/1404 |
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| author | Yanjie Xu Dongxiao Yao Weiqi Chen Hongyi Yan Dexiu Zhao Lingling Jiang Yicong Wang Xingquan Zhao Liping Liu Yongjun Wang Yuesong Pan Yilong Wang |
| author_facet | Yanjie Xu Dongxiao Yao Weiqi Chen Hongyi Yan Dexiu Zhao Lingling Jiang Yicong Wang Xingquan Zhao Liping Liu Yongjun Wang Yuesong Pan Yilong Wang |
| author_sort | Yanjie Xu |
| collection | DOAJ |
| description | In this study, we explored the relationship between the platelet endothelial aggregation receptor 1 (<i>PEAR1</i>) polymorphisms, platelet reactivity, and clinical outcomes in patients with minor stroke or transient ischemic attack (TIA). Randomized controlled trial subgroups were assessed, wherein patients received dual antiplatelet therapy for at least 21 days. Platelet reactivity was measured at different time intervals. Genotypes were categorized as wild-type, mutant heterozygous, and mutant homozygous. Clinical outcomes were evaluated after 90 days. The rs12041331 polymorphism predominantly influenced adenosine diphosphate channel platelet activity, with the AA genotype displaying significantly lower residual platelet activity to the P2Y12 response unit (<i>p</i> < 0.01). This effect was more evident after 7 days of dual antiplatelet treatment (<i>p</i> = 0.016). Mutant A allele carriers had decreased rates of recurrent stroke and complex endpoint events but were more prone to bleeding (<i>p</i> = 0.015). The rs2768759 polymorphism majorly impacted arachidonic acid (AA) channel platelet activity, which was particularly noticeable in the C allele carriers. Our regression analysis demonstrated that rs12041331 AA + GA and rs2768759 CA predicted 90-day post-stroke bleeding. In conclusion, the <i>PEAR1</i> polymorphisms rs12041331 and rs2768759 interfere with platelet aggregation and the performance of antiplatelet drugs. These genetic variations may contribute to bleeding events associated with minor stroke and TIA. |
| first_indexed | 2024-03-10T21:23:15Z |
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| id | doaj.art-201c634991fb410c90eb93ec4f6035e4 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T21:23:15Z |
| publishDate | 2023-09-01 |
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| series | Brain Sciences |
| spelling | doaj.art-201c634991fb410c90eb93ec4f6035e42023-11-19T15:52:27ZengMDPI AGBrain Sciences2076-34252023-09-011310140410.3390/brainsci13101404Using the <i>PEAR1</i> Polymorphisms Rs12041331 and Rs2768759 as Potential Predictive Markers of 90-Day Bleeding Events in the Context of Minor Strokes and Transient Ischemic AttackYanjie Xu0Dongxiao Yao1Weiqi Chen2Hongyi Yan3Dexiu Zhao4Lingling Jiang5Yicong Wang6Xingquan Zhao7Liping Liu8Yongjun Wang9Yuesong Pan10Yilong Wang11Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100069, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100069, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100069, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100069, ChinaDepartment of Neurology, Aviation General Hospital, Beijing 100025, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100069, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100069, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100069, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100069, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100069, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100069, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100069, ChinaIn this study, we explored the relationship between the platelet endothelial aggregation receptor 1 (<i>PEAR1</i>) polymorphisms, platelet reactivity, and clinical outcomes in patients with minor stroke or transient ischemic attack (TIA). Randomized controlled trial subgroups were assessed, wherein patients received dual antiplatelet therapy for at least 21 days. Platelet reactivity was measured at different time intervals. Genotypes were categorized as wild-type, mutant heterozygous, and mutant homozygous. Clinical outcomes were evaluated after 90 days. The rs12041331 polymorphism predominantly influenced adenosine diphosphate channel platelet activity, with the AA genotype displaying significantly lower residual platelet activity to the P2Y12 response unit (<i>p</i> < 0.01). This effect was more evident after 7 days of dual antiplatelet treatment (<i>p</i> = 0.016). Mutant A allele carriers had decreased rates of recurrent stroke and complex endpoint events but were more prone to bleeding (<i>p</i> = 0.015). The rs2768759 polymorphism majorly impacted arachidonic acid (AA) channel platelet activity, which was particularly noticeable in the C allele carriers. Our regression analysis demonstrated that rs12041331 AA + GA and rs2768759 CA predicted 90-day post-stroke bleeding. In conclusion, the <i>PEAR1</i> polymorphisms rs12041331 and rs2768759 interfere with platelet aggregation and the performance of antiplatelet drugs. These genetic variations may contribute to bleeding events associated with minor stroke and TIA.https://www.mdpi.com/2076-3425/13/10/1404<i>PEAR1</i> geneplatelet aggregationdual antiplatelet therapystroketransient ischemic attackgenetic polymorphism |
| spellingShingle | Yanjie Xu Dongxiao Yao Weiqi Chen Hongyi Yan Dexiu Zhao Lingling Jiang Yicong Wang Xingquan Zhao Liping Liu Yongjun Wang Yuesong Pan Yilong Wang Using the <i>PEAR1</i> Polymorphisms Rs12041331 and Rs2768759 as Potential Predictive Markers of 90-Day Bleeding Events in the Context of Minor Strokes and Transient Ischemic Attack Brain Sciences <i>PEAR1</i> gene platelet aggregation dual antiplatelet therapy stroke transient ischemic attack genetic polymorphism |
| title | Using the <i>PEAR1</i> Polymorphisms Rs12041331 and Rs2768759 as Potential Predictive Markers of 90-Day Bleeding Events in the Context of Minor Strokes and Transient Ischemic Attack |
| title_full | Using the <i>PEAR1</i> Polymorphisms Rs12041331 and Rs2768759 as Potential Predictive Markers of 90-Day Bleeding Events in the Context of Minor Strokes and Transient Ischemic Attack |
| title_fullStr | Using the <i>PEAR1</i> Polymorphisms Rs12041331 and Rs2768759 as Potential Predictive Markers of 90-Day Bleeding Events in the Context of Minor Strokes and Transient Ischemic Attack |
| title_full_unstemmed | Using the <i>PEAR1</i> Polymorphisms Rs12041331 and Rs2768759 as Potential Predictive Markers of 90-Day Bleeding Events in the Context of Minor Strokes and Transient Ischemic Attack |
| title_short | Using the <i>PEAR1</i> Polymorphisms Rs12041331 and Rs2768759 as Potential Predictive Markers of 90-Day Bleeding Events in the Context of Minor Strokes and Transient Ischemic Attack |
| title_sort | using the i pear1 i polymorphisms rs12041331 and rs2768759 as potential predictive markers of 90 day bleeding events in the context of minor strokes and transient ischemic attack |
| topic | <i>PEAR1</i> gene platelet aggregation dual antiplatelet therapy stroke transient ischemic attack genetic polymorphism |
| url | https://www.mdpi.com/2076-3425/13/10/1404 |
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