The Yeast Permease Agp2 Senses Cycloheximide and Undergoes Degradation That Requires the Small Protein Brp1-Cellular Fate of Agp2 in Response to Cycloheximide

The Yeast Permease Agp2 Senses Cycloheximide and Undergoes Degradation That Requires the Small Protein Brp1-Cellular Fate of Agp2 in Response to Cycloheximide

The <i>Saccharomyces cerevisiae</i> Agp2 is a plasma membrane protein initially reported to be an uptake transporter for L-carnitine. Agp2 was later rediscovered, together with three additional proteins, Sky1, Ptk2, and Brp1, to be involved in the uptake of the polyamine analogue bleomyc...

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Bibliographic Details
Main Authors: Ashima Mohanty, Abdallah Alhaj Sulaiman, Balasubramanian Moovarkumudalvan, Reem Ali, Mustapha Aouida, Dindial Ramotar
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
uptake transporter
sensor
drugs
protein synthesis inhibitor
cycloheximide
ubiquitinylation
Online Access:https://www.mdpi.com/1422-0067/24/8/6975

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