Association between Diffusion Tensor Imaging, inflammation and immunological alterations in unipolar and bipolar depression: a review
Introduction Major Depressive Disorder (MDD) and Bipolar Disorder Depression (BDD) are common psychiatric illnesses characterized by structural and functional brain alterations and signs of neuroinflammation. In line with the neuroinflammatory pathogenesis of depressive syndromes (Mechawar N, Savit...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2023-03-01
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| Series: | European Psychiatry |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933823012610/type/journal_article |
| _version_ | 1797617181479927808 |
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| author | R. Aronica P. Enrico P. Brambilla G. Delvecchio |
| author_facet | R. Aronica P. Enrico P. Brambilla G. Delvecchio |
| author_sort | R. Aronica |
| collection | DOAJ |
| description |
Introduction
Major Depressive Disorder (MDD) and Bipolar Disorder Depression (BDD) are common psychiatric illnesses characterized by structural and functional brain alterations and signs of neuroinflammation. In line with the neuroinflammatory pathogenesis of depressive syndromes (Mechawar N, Savitz J. Neuropathology of mood disorders: do we see the stigmata of inflammation? Transl Psychiatry. 2016;6(11):e946), recent studies have demonstrated how white matter (WM) microstructural impairments detected by Diffusion Tensor Imaging (DTI) are correlated to peripheral immunomarkers in depressed patients.
Objectives
In this context, the aim of our review is to report an updated overview of the evidence on the correlation between the blood immuno-markers changes and the brain WM disruptions in MDD and BDD patients.
Methods
Based on PRISMA 2020 guidelines (Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ. 2021;372), we performed a systematic search on original DTI studies exploring the association between WM integrity, neuroimmune alterations and inflammation in patients affected by MDD or BDD.
Results
Concerning MDD, most of the reviewed studies provided evidence of a link between systemic immune dysregulation, detected through the elevation of peripheral markers (IL-1β and TNF-alfa) or an altered ratio between proinflammatory and counterregulatory cytokines (IL-8/IL-10), and DTI alterations in specific WM tracts, such as the genu of corpus callosum and the IFOF. As for the BDD, we detected an increase of pro-inflammatory molecules (such as TNF-alfa, IL-8, IFN-γ etc.) that correlated with DTI changes in different cerebral areas such as cingulum, forceps, corona radiata, corpus callosum, longitudinal fasciculus and internal capsule. Furthermore, other molecules seem to play a specific role in BDD pathogenesis, including counter-regulatory cytokines, kynurenine and specific lymphocyte classes, such as Th1 and Th17.
Conclusions
Taken together, these pathogenetic insights could outline an integrated clinical perspective to affective disorders, helping psychiatrists to develop novel biotype-to-phenotype models of depression and opening the way to tailored approaches in treatments.
Disclosure of Interest
None Declared |
| first_indexed | 2024-03-11T07:51:15Z |
| format | Article |
| id | doaj.art-201f29ce2c2b456a83a154bae80cf1cb |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:51:15Z |
| publishDate | 2023-03-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-201f29ce2c2b456a83a154bae80cf1cb2023-11-17T05:06:32ZengCambridge University PressEuropean Psychiatry0924-93381778-35852023-03-0166S604S60410.1192/j.eurpsy.2023.1261Association between Diffusion Tensor Imaging, inflammation and immunological alterations in unipolar and bipolar depression: a reviewR. Aronica0P. Enrico1P. Brambilla2G. Delvecchio3Department of Pathophysiology and Transplantation, University of Milan, 20122 Milan Department of Neurosciences and Mental Health, Fondazione IRCCS Ca’ Granda-Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Pathophysiology and Transplantation, University of Milan, 20122 Milan Department of Neurosciences and Mental Health, Fondazione IRCCS Ca’ Granda-Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Pathophysiology and Transplantation, University of Milan, 20122 Milan Department of Neurosciences and Mental Health, Fondazione IRCCS Ca’ Granda-Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Neurosciences and Mental Health, Fondazione IRCCS Ca’ Granda-Ospedale Maggiore Policlinico, Milan, Italy Introduction Major Depressive Disorder (MDD) and Bipolar Disorder Depression (BDD) are common psychiatric illnesses characterized by structural and functional brain alterations and signs of neuroinflammation. In line with the neuroinflammatory pathogenesis of depressive syndromes (Mechawar N, Savitz J. Neuropathology of mood disorders: do we see the stigmata of inflammation? Transl Psychiatry. 2016;6(11):e946), recent studies have demonstrated how white matter (WM) microstructural impairments detected by Diffusion Tensor Imaging (DTI) are correlated to peripheral immunomarkers in depressed patients. Objectives In this context, the aim of our review is to report an updated overview of the evidence on the correlation between the blood immuno-markers changes and the brain WM disruptions in MDD and BDD patients. Methods Based on PRISMA 2020 guidelines (Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ. 2021;372), we performed a systematic search on original DTI studies exploring the association between WM integrity, neuroimmune alterations and inflammation in patients affected by MDD or BDD. Results Concerning MDD, most of the reviewed studies provided evidence of a link between systemic immune dysregulation, detected through the elevation of peripheral markers (IL-1β and TNF-alfa) or an altered ratio between proinflammatory and counterregulatory cytokines (IL-8/IL-10), and DTI alterations in specific WM tracts, such as the genu of corpus callosum and the IFOF. As for the BDD, we detected an increase of pro-inflammatory molecules (such as TNF-alfa, IL-8, IFN-γ etc.) that correlated with DTI changes in different cerebral areas such as cingulum, forceps, corona radiata, corpus callosum, longitudinal fasciculus and internal capsule. Furthermore, other molecules seem to play a specific role in BDD pathogenesis, including counter-regulatory cytokines, kynurenine and specific lymphocyte classes, such as Th1 and Th17. Conclusions Taken together, these pathogenetic insights could outline an integrated clinical perspective to affective disorders, helping psychiatrists to develop novel biotype-to-phenotype models of depression and opening the way to tailored approaches in treatments. Disclosure of Interest None Declaredhttps://www.cambridge.org/core/product/identifier/S0924933823012610/type/journal_article |
| spellingShingle | R. Aronica P. Enrico P. Brambilla G. Delvecchio Association between Diffusion Tensor Imaging, inflammation and immunological alterations in unipolar and bipolar depression: a review European Psychiatry |
| title | Association between Diffusion Tensor Imaging, inflammation and immunological alterations in unipolar and bipolar depression: a review |
| title_full | Association between Diffusion Tensor Imaging, inflammation and immunological alterations in unipolar and bipolar depression: a review |
| title_fullStr | Association between Diffusion Tensor Imaging, inflammation and immunological alterations in unipolar and bipolar depression: a review |
| title_full_unstemmed | Association between Diffusion Tensor Imaging, inflammation and immunological alterations in unipolar and bipolar depression: a review |
| title_short | Association between Diffusion Tensor Imaging, inflammation and immunological alterations in unipolar and bipolar depression: a review |
| title_sort | association between diffusion tensor imaging inflammation and immunological alterations in unipolar and bipolar depression a review |
| url | https://www.cambridge.org/core/product/identifier/S0924933823012610/type/journal_article |
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