Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P
<p>Abstract</p> <p>Substance P (SP) is a neuropeptide well known for its contribution to pain transmission in the spinal cord, however, less is known about the possible modulatory effects of SP. A new study by Gu and colleagues, published in <it>Molecular Pain </it>(200...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2005-11-01
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| Series: | Molecular Pain |
| Online Access: | http://www.molecularpain.com/content/1/1/34 |
| _version_ | 1818493303316807680 |
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| author | Yoshimura Megumu Ko Shanelle W Xu Hui Wu Long-Jun Zhuo Min |
| author_facet | Yoshimura Megumu Ko Shanelle W Xu Hui Wu Long-Jun Zhuo Min |
| author_sort | Yoshimura Megumu |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Substance P (SP) is a neuropeptide well known for its contribution to pain transmission in the spinal cord, however, less is known about the possible modulatory effects of SP. A new study by Gu and colleagues, published in <it>Molecular Pain </it>(2005, 1:20), describes its potential role in feed-forward inhibition in lamina V of the dorsal horn of the spinal cord. This inhibition seems to function through a direct excitation of GABAergic interneurons by substance P released from primary afferent fibers and has a distinct temporal phase of action from the well-described glutamate-dependent feed-forward inhibition. It is believed that through this inhibition, substance P can balance nociceptive output from the spinal cord.</p> |
| first_indexed | 2024-12-10T17:53:06Z |
| format | Article |
| id | doaj.art-201f97976ba0464a84b722e3501fce9e |
| institution | Directory Open Access Journal |
| issn | 1744-8069 |
| language | English |
| last_indexed | 2024-12-10T17:53:06Z |
| publishDate | 2005-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Pain |
| spelling | doaj.art-201f97976ba0464a84b722e3501fce9e2022-12-22T01:39:01ZengSAGE PublishingMolecular Pain1744-80692005-11-01113410.1186/1744-8069-1-34Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance PYoshimura MegumuKo Shanelle WXu HuiWu Long-JunZhuo Min<p>Abstract</p> <p>Substance P (SP) is a neuropeptide well known for its contribution to pain transmission in the spinal cord, however, less is known about the possible modulatory effects of SP. A new study by Gu and colleagues, published in <it>Molecular Pain </it>(2005, 1:20), describes its potential role in feed-forward inhibition in lamina V of the dorsal horn of the spinal cord. This inhibition seems to function through a direct excitation of GABAergic interneurons by substance P released from primary afferent fibers and has a distinct temporal phase of action from the well-described glutamate-dependent feed-forward inhibition. It is believed that through this inhibition, substance P can balance nociceptive output from the spinal cord.</p>http://www.molecularpain.com/content/1/1/34 |
| spellingShingle | Yoshimura Megumu Ko Shanelle W Xu Hui Wu Long-Jun Zhuo Min Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P Molecular Pain |
| title | Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P |
| title_full | Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P |
| title_fullStr | Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P |
| title_full_unstemmed | Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P |
| title_short | Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P |
| title_sort | feed forward inhibition a novel cellular mechanism for the analgesic effect of substance p |
| url | http://www.molecularpain.com/content/1/1/34 |
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