Dosimetric Comparisons between Proton Beam Therapy and Modern Photon Radiation Techniques for Stage I Non-Small Cell Lung Cancer According to Tumor Location
Herein, we investigated the dosimetric benefits for proton beam therapy (PBT) over modern photon radiation techniques according to tumor location (central, peripheral, and close to the chest wall) for stage I non-small cell lung cancer (NSCLC) patients. A total of 42 patients with stage I NSCLC were...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/24/6356 |
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| author | Unurjargal Bayasgalan Sung Ho Moon Tae Hyun Kim Tae Yoon Kim Seung Hyun Lee Yang-Gun Suh |
| author_facet | Unurjargal Bayasgalan Sung Ho Moon Tae Hyun Kim Tae Yoon Kim Seung Hyun Lee Yang-Gun Suh |
| author_sort | Unurjargal Bayasgalan |
| collection | DOAJ |
| description | Herein, we investigated the dosimetric benefits for proton beam therapy (PBT) over modern photon radiation techniques according to tumor location (central, peripheral, and close to the chest wall) for stage I non-small cell lung cancer (NSCLC) patients. A total of 42 patients with stage I NSCLC were treated with PBT with a total dose of 50–70 Gy in four or 10 fractions considering the risk of treatment-related toxicities. Simulation plans for three-dimensional conformal radiation therapy (3D-CRT), static-field intensity-modulated radiotherapy (IMRT), and volumetric-modulated arc therapy (VMAT) were retrospectively generated using the same treatment volumes as implemented in the PBT plans for these patients. Dosimetric improvements were observed with PBT as compared with all the photon-based radiation techniques with regards to the mean lung dose, lung V5 and V10, mean heart dose, and heart V5 and V10 in all locations. Moreover, lower radiation exposure to the chest wall was observed within PBT for peripherally located and close to the chest wall tumors. All radiotherapy modalities achieved clinically satisfactory treatment plans in the current study. Notably, the usage of PBT resulted in significant dosimetric improvements in the lung and heart over photon-based techniques at all tumor locations, including the periphery, for stage I NSCLC. |
| first_indexed | 2024-03-10T04:31:31Z |
| format | Article |
| id | doaj.art-20206ddd45cc45d598b92f90896616a8 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T04:31:31Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-20206ddd45cc45d598b92f90896616a82023-11-23T04:07:37ZengMDPI AGCancers2072-66942021-12-011324635610.3390/cancers13246356Dosimetric Comparisons between Proton Beam Therapy and Modern Photon Radiation Techniques for Stage I Non-Small Cell Lung Cancer According to Tumor LocationUnurjargal Bayasgalan0Sung Ho Moon1Tae Hyun Kim2Tae Yoon Kim3Seung Hyun Lee4Yang-Gun Suh5Proton Therapy Center, Research Institute and Hospital, National Cancer Center, Goyang 10408, KoreaProton Therapy Center, Research Institute and Hospital, National Cancer Center, Goyang 10408, KoreaProton Therapy Center, Research Institute and Hospital, National Cancer Center, Goyang 10408, KoreaProton Therapy Center, Research Institute and Hospital, National Cancer Center, Goyang 10408, KoreaProton Therapy Center, Research Institute and Hospital, National Cancer Center, Goyang 10408, KoreaProton Therapy Center, Research Institute and Hospital, National Cancer Center, Goyang 10408, KoreaHerein, we investigated the dosimetric benefits for proton beam therapy (PBT) over modern photon radiation techniques according to tumor location (central, peripheral, and close to the chest wall) for stage I non-small cell lung cancer (NSCLC) patients. A total of 42 patients with stage I NSCLC were treated with PBT with a total dose of 50–70 Gy in four or 10 fractions considering the risk of treatment-related toxicities. Simulation plans for three-dimensional conformal radiation therapy (3D-CRT), static-field intensity-modulated radiotherapy (IMRT), and volumetric-modulated arc therapy (VMAT) were retrospectively generated using the same treatment volumes as implemented in the PBT plans for these patients. Dosimetric improvements were observed with PBT as compared with all the photon-based radiation techniques with regards to the mean lung dose, lung V5 and V10, mean heart dose, and heart V5 and V10 in all locations. Moreover, lower radiation exposure to the chest wall was observed within PBT for peripherally located and close to the chest wall tumors. All radiotherapy modalities achieved clinically satisfactory treatment plans in the current study. Notably, the usage of PBT resulted in significant dosimetric improvements in the lung and heart over photon-based techniques at all tumor locations, including the periphery, for stage I NSCLC.https://www.mdpi.com/2072-6694/13/24/6356proton beam therapynon-small cell lung cancermean lung dosemean heart dosedosimetric comparison |
| spellingShingle | Unurjargal Bayasgalan Sung Ho Moon Tae Hyun Kim Tae Yoon Kim Seung Hyun Lee Yang-Gun Suh Dosimetric Comparisons between Proton Beam Therapy and Modern Photon Radiation Techniques for Stage I Non-Small Cell Lung Cancer According to Tumor Location Cancers proton beam therapy non-small cell lung cancer mean lung dose mean heart dose dosimetric comparison |
| title | Dosimetric Comparisons between Proton Beam Therapy and Modern Photon Radiation Techniques for Stage I Non-Small Cell Lung Cancer According to Tumor Location |
| title_full | Dosimetric Comparisons between Proton Beam Therapy and Modern Photon Radiation Techniques for Stage I Non-Small Cell Lung Cancer According to Tumor Location |
| title_fullStr | Dosimetric Comparisons between Proton Beam Therapy and Modern Photon Radiation Techniques for Stage I Non-Small Cell Lung Cancer According to Tumor Location |
| title_full_unstemmed | Dosimetric Comparisons between Proton Beam Therapy and Modern Photon Radiation Techniques for Stage I Non-Small Cell Lung Cancer According to Tumor Location |
| title_short | Dosimetric Comparisons between Proton Beam Therapy and Modern Photon Radiation Techniques for Stage I Non-Small Cell Lung Cancer According to Tumor Location |
| title_sort | dosimetric comparisons between proton beam therapy and modern photon radiation techniques for stage i non small cell lung cancer according to tumor location |
| topic | proton beam therapy non-small cell lung cancer mean lung dose mean heart dose dosimetric comparison |
| url | https://www.mdpi.com/2072-6694/13/24/6356 |
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