ABO Blood Type Is Associated with Thrombotic Risk in Patients with Nonvalvular Atrial Fibrillation
Blood type is reportedly correlated with the occurrence of cardiovascular diseases, presumably because of its effect on thrombogenicity. However, the relationship between blood type and thrombotic complications in atrial fibrillation (AF) remains unclear. This retrospective study analyzed the blood...
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| Format: | Article |
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MDPI AG
2022-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/11/3064 |
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| author | Albert Youngwoo Jang Jeongduk Seo Yae Min Park Yong Hoon Shin Joonpyo Lee Pyung Chun Oh Woong Chol Kang Wook-Jin Chung Jeonggeun Moon |
| author_facet | Albert Youngwoo Jang Jeongduk Seo Yae Min Park Yong Hoon Shin Joonpyo Lee Pyung Chun Oh Woong Chol Kang Wook-Jin Chung Jeonggeun Moon |
| author_sort | Albert Youngwoo Jang |
| collection | DOAJ |
| description | Blood type is reportedly correlated with the occurrence of cardiovascular diseases, presumably because of its effect on thrombogenicity. However, the relationship between blood type and thrombotic complications in atrial fibrillation (AF) remains unclear. This retrospective study analyzed the blood types of 1170 AF patients (mean age, 70 years; 58% men) who were followed up for up to 4 years. Patients with greater than mild mitral stenosis or prosthetic valves were excluded. The cohort included 305 (26%) type O, 413 (35%) type A, 333 (28%) type B, and 119 (10%) type AB patients. The primary endpoint of major adverse cerebrovascular events (MACE) occurred in 52 (4.4%) patients. When longitudinal outcomes were plotted, AB blood type patients had worse prognosis than non-AB blood type patients (<i>p</i> = 0.039), particularly type O blood patients (<i>p</i> = 0.049). Multivariate Cox regression analysis revealed that AB blood type was associated with higher MACE rates (adjusted hazard ratio, 2.01; 95% confidence interval, 1.01–4.00; <i>p</i> = 0.048) than non-AB blood types independent of anticoagulation therapy duration or CHA2DS2-VASc score. These indicate that AF patients with AB blood type are at an increased risk of MACE compared to those with non-AB blood type independent of the duration of anticoagulation or the CHA<sub>2</sub>DS<sub>2</sub>-VASc score. |
| first_indexed | 2024-03-10T01:11:57Z |
| format | Article |
| id | doaj.art-2022e45a15ef4ac48a00b7a62a2522ac |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T01:11:57Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-2022e45a15ef4ac48a00b7a62a2522ac2023-11-23T14:16:13ZengMDPI AGJournal of Clinical Medicine2077-03832022-05-011111306410.3390/jcm11113064ABO Blood Type Is Associated with Thrombotic Risk in Patients with Nonvalvular Atrial FibrillationAlbert Youngwoo Jang0Jeongduk Seo1Yae Min Park2Yong Hoon Shin3Joonpyo Lee4Pyung Chun Oh5Woong Chol Kang6Wook-Jin Chung7Jeonggeun Moon8Division of Cardiology, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon 21565, KoreaDivision of Cardiology, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon 21565, KoreaDivision of Cardiology, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon 21565, KoreaDivision of Cardiology, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon 21565, KoreaDivision of Cardiology, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon 21565, KoreaDivision of Cardiology, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon 21565, KoreaDivision of Cardiology, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon 21565, KoreaDivision of Cardiology, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon 21565, KoreaDivision of Cardiology, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon 21565, KoreaBlood type is reportedly correlated with the occurrence of cardiovascular diseases, presumably because of its effect on thrombogenicity. However, the relationship between blood type and thrombotic complications in atrial fibrillation (AF) remains unclear. This retrospective study analyzed the blood types of 1170 AF patients (mean age, 70 years; 58% men) who were followed up for up to 4 years. Patients with greater than mild mitral stenosis or prosthetic valves were excluded. The cohort included 305 (26%) type O, 413 (35%) type A, 333 (28%) type B, and 119 (10%) type AB patients. The primary endpoint of major adverse cerebrovascular events (MACE) occurred in 52 (4.4%) patients. When longitudinal outcomes were plotted, AB blood type patients had worse prognosis than non-AB blood type patients (<i>p</i> = 0.039), particularly type O blood patients (<i>p</i> = 0.049). Multivariate Cox regression analysis revealed that AB blood type was associated with higher MACE rates (adjusted hazard ratio, 2.01; 95% confidence interval, 1.01–4.00; <i>p</i> = 0.048) than non-AB blood types independent of anticoagulation therapy duration or CHA2DS2-VASc score. These indicate that AF patients with AB blood type are at an increased risk of MACE compared to those with non-AB blood type independent of the duration of anticoagulation or the CHA<sub>2</sub>DS<sub>2</sub>-VASc score.https://www.mdpi.com/2077-0383/11/11/3064ABO blood groupatrial fibrillationrisk factorstrokethromboembolism |
| spellingShingle | Albert Youngwoo Jang Jeongduk Seo Yae Min Park Yong Hoon Shin Joonpyo Lee Pyung Chun Oh Woong Chol Kang Wook-Jin Chung Jeonggeun Moon ABO Blood Type Is Associated with Thrombotic Risk in Patients with Nonvalvular Atrial Fibrillation Journal of Clinical Medicine ABO blood group atrial fibrillation risk factor stroke thromboembolism |
| title | ABO Blood Type Is Associated with Thrombotic Risk in Patients with Nonvalvular Atrial Fibrillation |
| title_full | ABO Blood Type Is Associated with Thrombotic Risk in Patients with Nonvalvular Atrial Fibrillation |
| title_fullStr | ABO Blood Type Is Associated with Thrombotic Risk in Patients with Nonvalvular Atrial Fibrillation |
| title_full_unstemmed | ABO Blood Type Is Associated with Thrombotic Risk in Patients with Nonvalvular Atrial Fibrillation |
| title_short | ABO Blood Type Is Associated with Thrombotic Risk in Patients with Nonvalvular Atrial Fibrillation |
| title_sort | abo blood type is associated with thrombotic risk in patients with nonvalvular atrial fibrillation |
| topic | ABO blood group atrial fibrillation risk factor stroke thromboembolism |
| url | https://www.mdpi.com/2077-0383/11/11/3064 |
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