Formylation of Electron-Rich Aromatic Rings Mediated by Dichloromethyl Methyl Ether and TiCl4: Scope and Limitations

Formylation of Electron-Rich Aromatic Rings Mediated by Dichloromethyl Methyl Ether and TiCl4: Scope and Limitations

Here the aromatic formylation mediated by TiCl4 and dichloromethyl methyl ether previously described by our group has been explored for a wide range of aromatic rings, including phenols, methoxy- and methylbenzenes, as an excellent way to produce aromatic aldehydes. Here we determine that the regios...

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Bibliographic Details
Main Authors: Iván Ramos-Tomillero, Marta Paradís-Bas, Ibério de Pinho Ribeiro Moreira, Josep María Bofill, Ernesto Nicolás, Fernando Albericio
Format: Article
Language:English
Published: MDPI AG 2015-03-01
Series:Molecules
Subjects:
formylation
TiCl4
aromatic rings
aldehydes
dichloromethyl methyl ether
Online Access:http://www.mdpi.com/1420-3049/20/4/5409
Description
Summary:Here the aromatic formylation mediated by TiCl4 and dichloromethyl methyl ether previously described by our group has been explored for a wide range of aromatic rings, including phenols, methoxy- and methylbenzenes, as an excellent way to produce aromatic aldehydes. Here we determine that the regioselectivity of this process is highly promoted by the coordination between the atoms present in the aromatic moiety and those in the metal core.
ISSN:1420-3049

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