Extrinsic and intrinsic determinants of nerve regeneration
After central nervous system (CNS) injury axons fail to regenerate often leading to persistent neurologic deficit although injured peripheral nervous system (PNS) axons mount a robust regenerative response that may lead to functional recovery. Some of the failures of CNS regeneration arise from the...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2011-01-01
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| Series: | Journal of Tissue Engineering |
| Online Access: | https://doi.org/10.1177/2041731411418392 |
| _version_ | 1818527545015926784 |
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| author | Toby A. Ferguson Young-Jin Son |
| author_facet | Toby A. Ferguson Young-Jin Son |
| author_sort | Toby A. Ferguson |
| collection | DOAJ |
| description | After central nervous system (CNS) injury axons fail to regenerate often leading to persistent neurologic deficit although injured peripheral nervous system (PNS) axons mount a robust regenerative response that may lead to functional recovery. Some of the failures of CNS regeneration arise from the many glial-based inhibitory molecules found in the injured CNS, whereas the intrinsic regenerative potential of some CNS neurons is actively curtailed during CNS maturation and limited after injury. In this review, the molecular basis for extrinsic and intrinsic modulation of axon regeneration within the nervous system is evaluated. A more complete understanding of the factors limiting axonal regeneration will provide a rational basis, which is used to develop improved treatments for nervous system injury. |
| first_indexed | 2024-12-11T06:37:30Z |
| format | Article |
| id | doaj.art-2024842b2fd241af944f2e33265c212d |
| institution | Directory Open Access Journal |
| issn | 2041-7314 |
| language | English |
| last_indexed | 2024-12-11T06:37:30Z |
| publishDate | 2011-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Tissue Engineering |
| spelling | doaj.art-2024842b2fd241af944f2e33265c212d2022-12-22T01:17:19ZengSAGE PublishingJournal of Tissue Engineering2041-73142011-01-01210.1177/204173141141839210.1177_2041731411418392Extrinsic and intrinsic determinants of nerve regenerationToby A. Ferguson0Young-Jin Son1 Department of Neurology, Temple University School of Medicine, Philadelphia, PA 19140, USA Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA 19140, USAAfter central nervous system (CNS) injury axons fail to regenerate often leading to persistent neurologic deficit although injured peripheral nervous system (PNS) axons mount a robust regenerative response that may lead to functional recovery. Some of the failures of CNS regeneration arise from the many glial-based inhibitory molecules found in the injured CNS, whereas the intrinsic regenerative potential of some CNS neurons is actively curtailed during CNS maturation and limited after injury. In this review, the molecular basis for extrinsic and intrinsic modulation of axon regeneration within the nervous system is evaluated. A more complete understanding of the factors limiting axonal regeneration will provide a rational basis, which is used to develop improved treatments for nervous system injury.https://doi.org/10.1177/2041731411418392 |
| spellingShingle | Toby A. Ferguson Young-Jin Son Extrinsic and intrinsic determinants of nerve regeneration Journal of Tissue Engineering |
| title | Extrinsic and intrinsic determinants of nerve
regeneration |
| title_full | Extrinsic and intrinsic determinants of nerve
regeneration |
| title_fullStr | Extrinsic and intrinsic determinants of nerve
regeneration |
| title_full_unstemmed | Extrinsic and intrinsic determinants of nerve
regeneration |
| title_short | Extrinsic and intrinsic determinants of nerve
regeneration |
| title_sort | extrinsic and intrinsic determinants of nerve regeneration |
| url | https://doi.org/10.1177/2041731411418392 |
| work_keys_str_mv | AT tobyaferguson extrinsicandintrinsicdeterminantsofnerveregeneration AT youngjinson extrinsicandintrinsicdeterminantsofnerveregeneration |