Synthesis and Bioactivities of Novel 1,3,4-Thiadiazole Derivatives of Glucosides
A series of novel 1,3,4-thiadiazole derivatives of glucosides were synthesized by the starting materials d-glucose and 5-amino-1,3,4-thiadiazole-2-thiol in good yields with employing a convergent synthetic route. The results of bioactivities showed that some of the target compounds exhibited good an...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2021.645876/full |
| _version_ | 1828969182185652224 |
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| author | Meihang Chen Xun Zhang Daowang Lu Hairong Luo Zengyan Zhou Xufeng Qin Wenneng Wu Guoping Zhang |
| author_facet | Meihang Chen Xun Zhang Daowang Lu Hairong Luo Zengyan Zhou Xufeng Qin Wenneng Wu Guoping Zhang |
| author_sort | Meihang Chen |
| collection | DOAJ |
| description | A series of novel 1,3,4-thiadiazole derivatives of glucosides were synthesized by the starting materials d-glucose and 5-amino-1,3,4-thiadiazole-2-thiol in good yields with employing a convergent synthetic route. The results of bioactivities showed that some of the target compounds exhibited good antifungal activities. Especially, compounds 4i showed higher bioactivities against Phytophthora infestans (P. infestans), with the EC50 values of 3.43, than that of Dimethomorph (5.52 μg/ml). In addition, the target compounds exhibited moderate to poor antibacterial activities against Xanthomonas oryzae pv. oryzae (Xoo), Xanthomonas campestris pv. citri (Xcc). |
| first_indexed | 2024-12-14T12:26:47Z |
| format | Article |
| id | doaj.art-2024ebcc3803498cab640487958606bd |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-14T12:26:47Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-2024ebcc3803498cab640487958606bd2022-12-21T23:01:18ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462021-03-01910.3389/fchem.2021.645876645876Synthesis and Bioactivities of Novel 1,3,4-Thiadiazole Derivatives of GlucosidesMeihang Chen0Xun Zhang1Daowang Lu2Hairong Luo3Zengyan Zhou4Xufeng Qin5Wenneng Wu6Guoping Zhang7Colleges of Material and Chemistry Engineering, Tongren University, Tongren, ChinaColleges of Material and Chemistry Engineering, Tongren University, Tongren, ChinaColleges of Material and Chemistry Engineering, Tongren University, Tongren, ChinaColleges of Material and Chemistry Engineering, Tongren University, Tongren, ChinaColleges of Material and Chemistry Engineering, Tongren University, Tongren, ChinaColleges of Material and Chemistry Engineering, Tongren University, Tongren, ChinaColleges of Food and Pharmaceutical Engineering, Guiyang University, Guiyang, ChinaColleges of Chemistry and Material Science, Huaibei Normal University, Huaibei, ChinaA series of novel 1,3,4-thiadiazole derivatives of glucosides were synthesized by the starting materials d-glucose and 5-amino-1,3,4-thiadiazole-2-thiol in good yields with employing a convergent synthetic route. The results of bioactivities showed that some of the target compounds exhibited good antifungal activities. Especially, compounds 4i showed higher bioactivities against Phytophthora infestans (P. infestans), with the EC50 values of 3.43, than that of Dimethomorph (5.52 μg/ml). In addition, the target compounds exhibited moderate to poor antibacterial activities against Xanthomonas oryzae pv. oryzae (Xoo), Xanthomonas campestris pv. citri (Xcc).https://www.frontiersin.org/articles/10.3389/fchem.2021.645876/fullthiadiazoleamideglucosidesynthesisbioactivity |
| spellingShingle | Meihang Chen Xun Zhang Daowang Lu Hairong Luo Zengyan Zhou Xufeng Qin Wenneng Wu Guoping Zhang Synthesis and Bioactivities of Novel 1,3,4-Thiadiazole Derivatives of Glucosides Frontiers in Chemistry thiadiazole amide glucoside synthesis bioactivity |
| title | Synthesis and Bioactivities of Novel 1,3,4-Thiadiazole Derivatives of Glucosides |
| title_full | Synthesis and Bioactivities of Novel 1,3,4-Thiadiazole Derivatives of Glucosides |
| title_fullStr | Synthesis and Bioactivities of Novel 1,3,4-Thiadiazole Derivatives of Glucosides |
| title_full_unstemmed | Synthesis and Bioactivities of Novel 1,3,4-Thiadiazole Derivatives of Glucosides |
| title_short | Synthesis and Bioactivities of Novel 1,3,4-Thiadiazole Derivatives of Glucosides |
| title_sort | synthesis and bioactivities of novel 1 3 4 thiadiazole derivatives of glucosides |
| topic | thiadiazole amide glucoside synthesis bioactivity |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2021.645876/full |
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