Reduced Expression of TMEM16A Impairs Nitric Oxide-Dependent Cl− Transport in Retinal Amacrine Cells

Reduced Expression of TMEM16A Impairs Nitric Oxide-Dependent Cl− Transport in Retinal Amacrine Cells

Postsynaptic cytosolic Cl− concentration determines whether GABAergic and glycinergic synapses are inhibitory or excitatory. We have shown that nitric oxide (NO) initiates the release of Cl− from acidic internal stores into the cytosol of retinal amacrine cells (ACs) thereby elevating cytosolic Cl−....

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Bibliographic Details
Main Authors: Tyler Christopher Rodriguez, Li Zhong, Hailey Simpson, Evanna Gleason
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
retina
nitric oxide (NO)
amacrine cell
TMEM16/anoctamin
CRISPR/Cas9
intracellular Cl−
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.937060/full

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