Circulating docosahexaenoic acid levels are associated with fetal insulin sensitivity.
Arachidonic acid (AA; C20∶4 n-6) and docosahexaenoic acid (DHA; C22∶6 n-3) are important long-chain polyunsaturated fatty acids (LC-PUFA) in maintaining pancreatic beta-cell structure and function. Newborns of gestational diabetic mothers are more susceptible to the development of type 2 diabetes in...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3890289?pdf=render |
| _version_ | 1818493378868805632 |
|---|---|
| author | Jin-Ping Zhao Emile Levy William D Fraser Pierre Julien Edgard Delvin Alain Montoudis Schohraya Spahis Carole Garofalo Anne Monique Nuyt Zhong-Cheng Luo |
| author_facet | Jin-Ping Zhao Emile Levy William D Fraser Pierre Julien Edgard Delvin Alain Montoudis Schohraya Spahis Carole Garofalo Anne Monique Nuyt Zhong-Cheng Luo |
| author_sort | Jin-Ping Zhao |
| collection | DOAJ |
| description | Arachidonic acid (AA; C20∶4 n-6) and docosahexaenoic acid (DHA; C22∶6 n-3) are important long-chain polyunsaturated fatty acids (LC-PUFA) in maintaining pancreatic beta-cell structure and function. Newborns of gestational diabetic mothers are more susceptible to the development of type 2 diabetes in adulthood. It is not known whether low circulating AA or DHA is involved in perinatally "programming" this susceptibility. This study aimed to assess whether circulating concentrations of AA, DHA and other fatty acids are associated with fetal insulin sensitivity or beta-cell function, and whether low circulating concentrations of AA or DHA are involved in compromised fetal insulin sensitivity in gestational diabetic pregnancies.In a prospective singleton pregnancy cohort, maternal (32-35 weeks gestation) and cord plasma fatty acids were assessed in relation to surrogate indicators of fetal insulin sensitivity (cord plasma glucose-to-insulin ratio, proinsulin concentration) and beta-cell function (proinsulin-to-insulin ratio) in 108 mother-newborn pairs. Cord plasma DHA levels (in percentage of total fatty acids) were lower comparing newborns of gestational diabetic (n = 24) vs. non-diabetic pregnancies (2.9% vs. 3.5%, P = 0.01). Adjusting for gestational age at blood sampling, lower cord plasma DHA levels were associated with lower fetal insulin sensitivity (lower glucose-to-insulin ratio, r = 0.20, P = 0.036; higher proinsulin concentration, r = -0.37, P <0.0001). The associations remained after adjustment for maternal and newborn characteristics. Cord plasma saturated fatty acids C18∶0 and C20∶0 were negatively correlated with fetal insulin sensitivity, but their levels were not different between gestational diabetic and non-diabetic pregnancies. Cord plasma AA levels were not correlated with fetal insulin sensitivity.Low circulating DHA levels are associated with compromised fetal insulin sensitivity, and may be involved in perinatally "programming" the susceptibility to type 2 diabetes in the offspring of gestational diabetic mothers. |
| first_indexed | 2024-12-10T17:54:22Z |
| format | Article |
| id | doaj.art-202783ccbda6449398f06ed556247ce5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T17:54:22Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-202783ccbda6449398f06ed556247ce52022-12-22T01:38:58ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0191e8505410.1371/journal.pone.0085054Circulating docosahexaenoic acid levels are associated with fetal insulin sensitivity.Jin-Ping ZhaoEmile LevyWilliam D FraserPierre JulienEdgard DelvinAlain MontoudisSchohraya SpahisCarole GarofaloAnne Monique NuytZhong-Cheng LuoArachidonic acid (AA; C20∶4 n-6) and docosahexaenoic acid (DHA; C22∶6 n-3) are important long-chain polyunsaturated fatty acids (LC-PUFA) in maintaining pancreatic beta-cell structure and function. Newborns of gestational diabetic mothers are more susceptible to the development of type 2 diabetes in adulthood. It is not known whether low circulating AA or DHA is involved in perinatally "programming" this susceptibility. This study aimed to assess whether circulating concentrations of AA, DHA and other fatty acids are associated with fetal insulin sensitivity or beta-cell function, and whether low circulating concentrations of AA or DHA are involved in compromised fetal insulin sensitivity in gestational diabetic pregnancies.In a prospective singleton pregnancy cohort, maternal (32-35 weeks gestation) and cord plasma fatty acids were assessed in relation to surrogate indicators of fetal insulin sensitivity (cord plasma glucose-to-insulin ratio, proinsulin concentration) and beta-cell function (proinsulin-to-insulin ratio) in 108 mother-newborn pairs. Cord plasma DHA levels (in percentage of total fatty acids) were lower comparing newborns of gestational diabetic (n = 24) vs. non-diabetic pregnancies (2.9% vs. 3.5%, P = 0.01). Adjusting for gestational age at blood sampling, lower cord plasma DHA levels were associated with lower fetal insulin sensitivity (lower glucose-to-insulin ratio, r = 0.20, P = 0.036; higher proinsulin concentration, r = -0.37, P <0.0001). The associations remained after adjustment for maternal and newborn characteristics. Cord plasma saturated fatty acids C18∶0 and C20∶0 were negatively correlated with fetal insulin sensitivity, but their levels were not different between gestational diabetic and non-diabetic pregnancies. Cord plasma AA levels were not correlated with fetal insulin sensitivity.Low circulating DHA levels are associated with compromised fetal insulin sensitivity, and may be involved in perinatally "programming" the susceptibility to type 2 diabetes in the offspring of gestational diabetic mothers.http://europepmc.org/articles/PMC3890289?pdf=render |
| spellingShingle | Jin-Ping Zhao Emile Levy William D Fraser Pierre Julien Edgard Delvin Alain Montoudis Schohraya Spahis Carole Garofalo Anne Monique Nuyt Zhong-Cheng Luo Circulating docosahexaenoic acid levels are associated with fetal insulin sensitivity. PLoS ONE |
| title | Circulating docosahexaenoic acid levels are associated with fetal insulin sensitivity. |
| title_full | Circulating docosahexaenoic acid levels are associated with fetal insulin sensitivity. |
| title_fullStr | Circulating docosahexaenoic acid levels are associated with fetal insulin sensitivity. |
| title_full_unstemmed | Circulating docosahexaenoic acid levels are associated with fetal insulin sensitivity. |
| title_short | Circulating docosahexaenoic acid levels are associated with fetal insulin sensitivity. |
| title_sort | circulating docosahexaenoic acid levels are associated with fetal insulin sensitivity |
| url | http://europepmc.org/articles/PMC3890289?pdf=render |
| work_keys_str_mv | AT jinpingzhao circulatingdocosahexaenoicacidlevelsareassociatedwithfetalinsulinsensitivity AT emilelevy circulatingdocosahexaenoicacidlevelsareassociatedwithfetalinsulinsensitivity AT williamdfraser circulatingdocosahexaenoicacidlevelsareassociatedwithfetalinsulinsensitivity AT pierrejulien circulatingdocosahexaenoicacidlevelsareassociatedwithfetalinsulinsensitivity AT edgarddelvin circulatingdocosahexaenoicacidlevelsareassociatedwithfetalinsulinsensitivity AT alainmontoudis circulatingdocosahexaenoicacidlevelsareassociatedwithfetalinsulinsensitivity AT schohrayaspahis circulatingdocosahexaenoicacidlevelsareassociatedwithfetalinsulinsensitivity AT carolegarofalo circulatingdocosahexaenoicacidlevelsareassociatedwithfetalinsulinsensitivity AT annemoniquenuyt circulatingdocosahexaenoicacidlevelsareassociatedwithfetalinsulinsensitivity AT zhongchengluo circulatingdocosahexaenoicacidlevelsareassociatedwithfetalinsulinsensitivity |