Anti-VEGF therapy prevents Müller intracellular edema by decreasing VEGF-A in diabetic retinopathy

Anti-VEGF therapy prevents Müller intracellular edema by decreasing VEGF-A in diabetic retinopathy

Abstract Background Although vascular endothelial growth factor A (VEGF-A) is known to play a key role in causing retinal edema, whether and how VEGF-A induces intracellular edema in the retina still remains unclear. Methods Sprague-Dawley rats were rendered diabetic with intraperitoneal injection o...

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Bibliographic Details
Main Authors: Tianqin Wang, Chaoyang Zhang, Hai Xie, Mengmeng Jiang, Haibin Tian, Lixia Lu, Guo-Tong Xu, Lin Liu, Jingfa Zhang
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Eye and Vision
Subjects:
Diabetic retinopathy
Diabetic macular edema
Müller cell
Anti-VEGF
Intracellular edema
Online Access:https://doi.org/10.1186/s40662-021-00237-3

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