NLRC4 Inflammasome-Driven Immunogenicity of a Recombinant MVA Mucosal Vaccine Encoding Flagellin

NLRC4 Inflammasome-Driven Immunogenicity of a Recombinant MVA Mucosal Vaccine Encoding Flagellin

Bacterial flagellin enhances innate and adaptive immune responses and is considered a promising adjuvant for the development of vaccines against infectious diseases and cancer. Antigen-presenting cells recognize flagellin with the extracellular TLR5 and the intracellular NLRC4 inflammasome-mediated...

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Bibliographic Details
Main Authors: Stephanie L. Sanos, Ronny Kassub, Marco Testori, Marlene Geiger, Juliane Pätzold, Raphael Giessel, Johanna Knallinger, Barbara Bathke, Fabienne Gräbnitz, Kay Brinkmann, Paul Chaplin, Mark Suter, Hubertus Hochrein, Henning Lauterbach
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
mucosal vaccines
MVA
flagellin
inflammasome
intestinal mucosa
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01988/full

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