Pentraxin 3: An Immuno-regulator in the Lungs
Pentraxin-3 (PTX3), is a soluble pattern recognition receptor (PRR) and constitutes humoral component of the innate immune system. It interacts with pathogenic moieties, infected and dying host cells and facilitates their removal through activation of appropriate innate and adaptive mechanisms. PTX3...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-05-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00127/full |
| _version_ | 1818162766177894400 |
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| author | Jyoti eBalhara Latifa eKoussih Latifa eKoussih Jingbo eZhang Jingbo eZhang Abdelilah Soussi Gounni |
| author_facet | Jyoti eBalhara Latifa eKoussih Latifa eKoussih Jingbo eZhang Jingbo eZhang Abdelilah Soussi Gounni |
| author_sort | Jyoti eBalhara |
| collection | DOAJ |
| description | Pentraxin-3 (PTX3), is a soluble pattern recognition receptor (PRR) and constitutes humoral component of the innate immune system. It interacts with pathogenic moieties, infected and dying host cells and facilitates their removal through activation of appropriate innate and adaptive mechanisms. PTX3 is secreted by a diverse variety of cells, ranging from immune cells to structural cells, in response to toll like receptor (TLR) engagement, inflammatory stimuli, physical and chemical stress. Further, PTX3 plays an essential role in female fertility as it facilitates the organization of extracellular matrix in cumulus oophorus. Such activity is also implicated in post-inflammation tissue repair. Altogether, PTX3 is a multifunctional protein and plays a non-redundant role in providing immunity against potential immunological dangers. Hence, it would be noteworthy to assess its role in lung immunity, as lungs are at a constant risk of infections and tissue damage attributable to perpetual exposure to foreign agents in air. |
| first_indexed | 2024-12-11T16:38:53Z |
| format | Article |
| id | doaj.art-20299a6dc1724b679bc13b85b76fad9b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T16:38:53Z |
| publishDate | 2013-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-20299a6dc1724b679bc13b85b76fad9b2022-12-22T00:58:23ZengFrontiers Media S.A.Frontiers in Immunology1664-32242013-05-01410.3389/fimmu.2013.0012748773Pentraxin 3: An Immuno-regulator in the LungsJyoti eBalhara0Latifa eKoussih1Latifa eKoussih2Jingbo eZhang3Jingbo eZhang4Abdelilah Soussi Gounni5University of ManitobaUniversity of ManitobaUniversity St BonifaceUniversity of ManitobaXinqiao Hospital, Third Military Medical UniversityUniversity of ManitobaPentraxin-3 (PTX3), is a soluble pattern recognition receptor (PRR) and constitutes humoral component of the innate immune system. It interacts with pathogenic moieties, infected and dying host cells and facilitates their removal through activation of appropriate innate and adaptive mechanisms. PTX3 is secreted by a diverse variety of cells, ranging from immune cells to structural cells, in response to toll like receptor (TLR) engagement, inflammatory stimuli, physical and chemical stress. Further, PTX3 plays an essential role in female fertility as it facilitates the organization of extracellular matrix in cumulus oophorus. Such activity is also implicated in post-inflammation tissue repair. Altogether, PTX3 is a multifunctional protein and plays a non-redundant role in providing immunity against potential immunological dangers. Hence, it would be noteworthy to assess its role in lung immunity, as lungs are at a constant risk of infections and tissue damage attributable to perpetual exposure to foreign agents in air.http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00127/fullImmune SystemTNFIL-1βlungsPTX3complements |
| spellingShingle | Jyoti eBalhara Latifa eKoussih Latifa eKoussih Jingbo eZhang Jingbo eZhang Abdelilah Soussi Gounni Pentraxin 3: An Immuno-regulator in the Lungs Frontiers in Immunology Immune System TNF IL-1β lungs PTX3 complements |
| title | Pentraxin 3: An Immuno-regulator in the Lungs |
| title_full | Pentraxin 3: An Immuno-regulator in the Lungs |
| title_fullStr | Pentraxin 3: An Immuno-regulator in the Lungs |
| title_full_unstemmed | Pentraxin 3: An Immuno-regulator in the Lungs |
| title_short | Pentraxin 3: An Immuno-regulator in the Lungs |
| title_sort | pentraxin 3 an immuno regulator in the lungs |
| topic | Immune System TNF IL-1β lungs PTX3 complements |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00127/full |
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