3157 Relationship between abnormal nocturnal blood pressure patterns and end-organ damage following heart transplantation.
OBJECTIVES/SPECIFIC AIMS: Heart transplant (HTx) recipients are more likely to exhibit abnormal circadian blood pressure (BP) patterns (e.g., lack of nocturnal dip in BP) compared with the general population. Our goal was to assess the relationship between abnormal circadian BP patterns and end-orga...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2019-03-01
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| Series: | Journal of Clinical and Translational Science |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2059866119001249/type/journal_article |
| _version_ | 1811156623618473984 |
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| author | Kris Oreschak Eugene E. Wolfel Amrut V. Ambardekar Christina L. Aquilante |
| author_facet | Kris Oreschak Eugene E. Wolfel Amrut V. Ambardekar Christina L. Aquilante |
| author_sort | Kris Oreschak |
| collection | DOAJ |
| description | OBJECTIVES/SPECIFIC AIMS: Heart transplant (HTx) recipients are more likely to exhibit abnormal circadian blood pressure (BP) patterns (e.g., lack of nocturnal dip in BP) compared with the general population. Our goal was to assess the relationship between abnormal circadian BP patterns and end-organ damage in HTx recipients. METHODS/STUDY POPULATION: The retrospective study included 30 patients who were ≥ 6 months post-heart transplant and had 24-hour ambulatory BP data collected during a parent study. Nocturnal BP decline was categorized as: ≥10% decline, dipper; <10% decline, non-dipper. The primary end-organ damage outcomes we plan to analyze are left ventricular hypertrophy (LVH), chronic kidney disease (CKD), and proteinuria. The association between nocturnal BP decline and the primary outcomes will be analyzed using logistic regression. RESULTS/ANTICIPATED RESULTS: The study cohort consists of 83% men and 83% Caucasians (mean age=57±14 years; mean time post-transplant =9.0±6.6 years). Systolic and diastolic non-dippers represent 53.3% and 40% of the cohort, respectively. Data are currently being analyzed for the association between nocturnal BP dipping status and LVH, CKD, and proteinuria. These findings will be presented at the conference. DISCUSSION/SIGNIFICANCE OF IMPACT: An understanding of factors, such as abnormal circadian BP patterns, that contribute to the development of end-organ damage following HTx may provide opportunities to improve BP management and prevent adverse complications in this high-risk population. |
| first_indexed | 2024-04-10T04:54:28Z |
| format | Article |
| id | doaj.art-202ad066d8bd49e5a22395086004ad74 |
| institution | Directory Open Access Journal |
| issn | 2059-8661 |
| language | English |
| last_indexed | 2024-04-10T04:54:28Z |
| publishDate | 2019-03-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Clinical and Translational Science |
| spelling | doaj.art-202ad066d8bd49e5a22395086004ad742023-03-09T12:30:29ZengCambridge University PressJournal of Clinical and Translational Science2059-86612019-03-013525210.1017/cts.2019.1243157 Relationship between abnormal nocturnal blood pressure patterns and end-organ damage following heart transplantation.Kris Oreschak0Eugene E. Wolfel1Amrut V. Ambardekar2Christina L. Aquilante3University of Colorado at DenverUniversity of Colorado at DenverUniversity of Colorado at DenverUniversity of Colorado at DenverOBJECTIVES/SPECIFIC AIMS: Heart transplant (HTx) recipients are more likely to exhibit abnormal circadian blood pressure (BP) patterns (e.g., lack of nocturnal dip in BP) compared with the general population. Our goal was to assess the relationship between abnormal circadian BP patterns and end-organ damage in HTx recipients. METHODS/STUDY POPULATION: The retrospective study included 30 patients who were ≥ 6 months post-heart transplant and had 24-hour ambulatory BP data collected during a parent study. Nocturnal BP decline was categorized as: ≥10% decline, dipper; <10% decline, non-dipper. The primary end-organ damage outcomes we plan to analyze are left ventricular hypertrophy (LVH), chronic kidney disease (CKD), and proteinuria. The association between nocturnal BP decline and the primary outcomes will be analyzed using logistic regression. RESULTS/ANTICIPATED RESULTS: The study cohort consists of 83% men and 83% Caucasians (mean age=57±14 years; mean time post-transplant =9.0±6.6 years). Systolic and diastolic non-dippers represent 53.3% and 40% of the cohort, respectively. Data are currently being analyzed for the association between nocturnal BP dipping status and LVH, CKD, and proteinuria. These findings will be presented at the conference. DISCUSSION/SIGNIFICANCE OF IMPACT: An understanding of factors, such as abnormal circadian BP patterns, that contribute to the development of end-organ damage following HTx may provide opportunities to improve BP management and prevent adverse complications in this high-risk population.https://www.cambridge.org/core/product/identifier/S2059866119001249/type/journal_article |
| spellingShingle | Kris Oreschak Eugene E. Wolfel Amrut V. Ambardekar Christina L. Aquilante 3157 Relationship between abnormal nocturnal blood pressure patterns and end-organ damage following heart transplantation. Journal of Clinical and Translational Science |
| title | 3157 Relationship between abnormal nocturnal blood pressure patterns and end-organ damage following heart transplantation. |
| title_full | 3157 Relationship between abnormal nocturnal blood pressure patterns and end-organ damage following heart transplantation. |
| title_fullStr | 3157 Relationship between abnormal nocturnal blood pressure patterns and end-organ damage following heart transplantation. |
| title_full_unstemmed | 3157 Relationship between abnormal nocturnal blood pressure patterns and end-organ damage following heart transplantation. |
| title_short | 3157 Relationship between abnormal nocturnal blood pressure patterns and end-organ damage following heart transplantation. |
| title_sort | 3157 relationship between abnormal nocturnal blood pressure patterns and end organ damage following heart transplantation |
| url | https://www.cambridge.org/core/product/identifier/S2059866119001249/type/journal_article |
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