Perinatal granulopoiesis and risk of pediatric asthma
There are perinatal characteristics, such as gestational age, reproducibly associated with the risk for pediatric asthma. Identification of biologic processes influenced by these characteristics could facilitate risk stratification or new therapeutic targets. We hypothesized that transcriptional cha...
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2021-02-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/63745 |
| _version_ | 1811202612403372032 |
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| author | Benjamin A Turturice Juliana Theorell Mary Dawn Koenig Lisa Tussing-Humphreys Diane R Gold Augusto A Litonjua Emily Oken Sheryl L Rifas-Shiman David L Perkins Patricia W Finn |
| author_facet | Benjamin A Turturice Juliana Theorell Mary Dawn Koenig Lisa Tussing-Humphreys Diane R Gold Augusto A Litonjua Emily Oken Sheryl L Rifas-Shiman David L Perkins Patricia W Finn |
| author_sort | Benjamin A Turturice |
| collection | DOAJ |
| description | There are perinatal characteristics, such as gestational age, reproducibly associated with the risk for pediatric asthma. Identification of biologic processes influenced by these characteristics could facilitate risk stratification or new therapeutic targets. We hypothesized that transcriptional changes associated with multiple epidemiologic risk factors would be mediators of pediatric asthma risk. Using publicly available transcriptomic data from cord blood mononuclear cells, transcription of genes involved in myeloid differentiation was observed to be inversely associated with a pediatric asthma risk stratification based on multiple perinatal risk factors. This gene signature was validated in an independent prospective cohort and was specifically associated with genes localizing to neutrophil-specific granules. Further validation demonstrated that umbilical cord blood serum concentration of PGLYRP-1, a specific granule protein, was inversely associated with mid-childhood current asthma and early-teen FEV1/FVCx100. Thus, neutrophil-specific granule abundance at birth predicts risk for pediatric asthma and pulmonary function in adolescence. |
| first_indexed | 2024-04-12T02:41:42Z |
| format | Article |
| id | doaj.art-202db176b8b247c2a0ab69d54362701e |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:41:42Z |
| publishDate | 2021-02-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-202db176b8b247c2a0ab69d54362701e2022-12-22T03:51:17ZengeLife Sciences Publications LtdeLife2050-084X2021-02-011010.7554/eLife.63745Perinatal granulopoiesis and risk of pediatric asthmaBenjamin A Turturice0https://orcid.org/0000-0001-9382-4612Juliana Theorell1Mary Dawn Koenig2Lisa Tussing-Humphreys3Diane R Gold4Augusto A Litonjua5Emily Oken6Sheryl L Rifas-Shiman7David L Perkins8Patricia W Finn9Department of Microbiology and Immunology, University of Illinois, Chicago, United States; Department of Medicine, Division of Pulmonary, Critical Care, Sleep, and Allergy, University of Illinois, Chicago, United StatesDepartment of Medicine, Division of Pulmonary, Critical Care, Sleep, and Allergy, University of Illinois, Chicago, United StatesDepartment of Women, Children and Family Health Science, College of Nursing, University of Illinois, Chicago, United StatesDepartment of Medicine and Cancer Center, University of Illinois, Chicago, United StatesChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, United StatesDivision of Pulmonary Medicine, Department of Pediatrics, University of Rochester, Rochester, United StatesDivision of Chronic Disease Research Across the Life Course, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, United StatesDivision of Chronic Disease Research Across the Life Course, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, United StatesDepartment of Medicine, Division of Nephrology, University of Illinois, Chicago, United States; Department of Bioengineering, University of Illinois, Chicago, United StatesDepartment of Microbiology and Immunology, University of Illinois, Chicago, United States; Department of Medicine, Division of Pulmonary, Critical Care, Sleep, and Allergy, University of Illinois, Chicago, United States; Department of Bioengineering, University of Illinois, Chicago, United StatesThere are perinatal characteristics, such as gestational age, reproducibly associated with the risk for pediatric asthma. Identification of biologic processes influenced by these characteristics could facilitate risk stratification or new therapeutic targets. We hypothesized that transcriptional changes associated with multiple epidemiologic risk factors would be mediators of pediatric asthma risk. Using publicly available transcriptomic data from cord blood mononuclear cells, transcription of genes involved in myeloid differentiation was observed to be inversely associated with a pediatric asthma risk stratification based on multiple perinatal risk factors. This gene signature was validated in an independent prospective cohort and was specifically associated with genes localizing to neutrophil-specific granules. Further validation demonstrated that umbilical cord blood serum concentration of PGLYRP-1, a specific granule protein, was inversely associated with mid-childhood current asthma and early-teen FEV1/FVCx100. Thus, neutrophil-specific granule abundance at birth predicts risk for pediatric asthma and pulmonary function in adolescence.https://elifesciences.org/articles/63745asthmapeptidoglycan recognition proteingranulocytesfetal bloodrisk factorallergy |
| spellingShingle | Benjamin A Turturice Juliana Theorell Mary Dawn Koenig Lisa Tussing-Humphreys Diane R Gold Augusto A Litonjua Emily Oken Sheryl L Rifas-Shiman David L Perkins Patricia W Finn Perinatal granulopoiesis and risk of pediatric asthma eLife asthma peptidoglycan recognition protein granulocytes fetal blood risk factor allergy |
| title | Perinatal granulopoiesis and risk of pediatric asthma |
| title_full | Perinatal granulopoiesis and risk of pediatric asthma |
| title_fullStr | Perinatal granulopoiesis and risk of pediatric asthma |
| title_full_unstemmed | Perinatal granulopoiesis and risk of pediatric asthma |
| title_short | Perinatal granulopoiesis and risk of pediatric asthma |
| title_sort | perinatal granulopoiesis and risk of pediatric asthma |
| topic | asthma peptidoglycan recognition protein granulocytes fetal blood risk factor allergy |
| url | https://elifesciences.org/articles/63745 |
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