Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques
The existence of HIV reservoir and ongoing replication despite antiretroviral therapy (ART) represents a barrier for cure efforts. Here, using SIV/SHIV-infected rhesus macaque suppressed with ART for one year, the authors characterize multiple lymphoid and non-lymphoid tissues and show that while th...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-21724-0 |
| _version_ | 1818430991843196928 |
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| author | Anthony M. Cadena John D. Ventura Peter Abbink Erica N. Borducchi Hubert Tuyishime Noe B. Mercado Victoria Walker-Sperling Mazuba Siamatu Po-Ting Liu Abishek Chandrashekar Joseph P. Nkolola Katherine McMahan Nicole Kordana Venous Hamza Esther A. Bondzie Emily Fray Mithra Kumar Stephanie Fischinger Sally A. Shin Mark G. Lewis Robert F. Siliciano Galit Alter Dan H. Barouch |
| author_facet | Anthony M. Cadena John D. Ventura Peter Abbink Erica N. Borducchi Hubert Tuyishime Noe B. Mercado Victoria Walker-Sperling Mazuba Siamatu Po-Ting Liu Abishek Chandrashekar Joseph P. Nkolola Katherine McMahan Nicole Kordana Venous Hamza Esther A. Bondzie Emily Fray Mithra Kumar Stephanie Fischinger Sally A. Shin Mark G. Lewis Robert F. Siliciano Galit Alter Dan H. Barouch |
| author_sort | Anthony M. Cadena |
| collection | DOAJ |
| description | The existence of HIV reservoir and ongoing replication despite antiretroviral therapy (ART) represents a barrier for cure efforts. Here, using SIV/SHIV-infected rhesus macaque suppressed with ART for one year, the authors characterize multiple lymphoid and non-lymphoid tissues and show that while the viral reservoir exhibits a wide anatomic heterogeneity, persistent viral transcription is mainly restricted to secondary lymphoid organs. |
| first_indexed | 2024-12-14T15:42:13Z |
| format | Article |
| id | doaj.art-202e143cd50c4ecea53a829693bdf039 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T15:42:13Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-202e143cd50c4ecea53a829693bdf0392022-12-21T22:55:36ZengNature PortfolioNature Communications2041-17232021-03-0112111110.1038/s41467-021-21724-0Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus MacaquesAnthony M. Cadena0John D. Ventura1Peter Abbink2Erica N. Borducchi3Hubert Tuyishime4Noe B. Mercado5Victoria Walker-Sperling6Mazuba Siamatu7Po-Ting Liu8Abishek Chandrashekar9Joseph P. Nkolola10Katherine McMahan11Nicole Kordana12Venous Hamza13Esther A. Bondzie14Emily Fray15Mithra Kumar16Stephanie Fischinger17Sally A. Shin18Mark G. Lewis19Robert F. Siliciano20Galit Alter21Dan H. Barouch22Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical SchoolCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical SchoolCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical SchoolCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical SchoolCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical SchoolCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical SchoolCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical SchoolCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical SchoolCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical SchoolCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical SchoolCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical SchoolCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical SchoolCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical SchoolCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical SchoolCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical SchoolDepartment of Medicine, Johns Hopkins University School of MedicineDepartment of Medicine, Johns Hopkins University School of MedicineRagon Institute of MGH, MIT, and HarvardRagon Institute of MGH, MIT, and HarvardBioqualDepartment of Medicine, Johns Hopkins University School of MedicineRagon Institute of MGH, MIT, and HarvardCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical SchoolThe existence of HIV reservoir and ongoing replication despite antiretroviral therapy (ART) represents a barrier for cure efforts. Here, using SIV/SHIV-infected rhesus macaque suppressed with ART for one year, the authors characterize multiple lymphoid and non-lymphoid tissues and show that while the viral reservoir exhibits a wide anatomic heterogeneity, persistent viral transcription is mainly restricted to secondary lymphoid organs.https://doi.org/10.1038/s41467-021-21724-0 |
| spellingShingle | Anthony M. Cadena John D. Ventura Peter Abbink Erica N. Borducchi Hubert Tuyishime Noe B. Mercado Victoria Walker-Sperling Mazuba Siamatu Po-Ting Liu Abishek Chandrashekar Joseph P. Nkolola Katherine McMahan Nicole Kordana Venous Hamza Esther A. Bondzie Emily Fray Mithra Kumar Stephanie Fischinger Sally A. Shin Mark G. Lewis Robert F. Siliciano Galit Alter Dan H. Barouch Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques Nature Communications |
| title | Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques |
| title_full | Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques |
| title_fullStr | Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques |
| title_full_unstemmed | Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques |
| title_short | Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques |
| title_sort | persistence of viral rna in lymph nodes in art suppressed siv shiv infected rhesus macaques |
| url | https://doi.org/10.1038/s41467-021-21724-0 |
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