Anti-inflammatory and antiviral activities of compounds from the fruit of Pouteria caimito
AbstractPouteria caimito is a commercially valuable tropical fruit tree and has medicinal effects in Brazilian folklore. In this thesis, thirteen compounds were isolated for the first time from the fruit of P. caimito by ethanol extraction and various chromatographic column chromatography methods. T...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Cogent Food & Agriculture |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/23311932.2023.2298023 |
| _version_ | 1797353514321575936 |
|---|---|
| author | Hai-Yue Zhao Hao-Yue Zhu Qing Tang Qiang Lin Yi-Kun Hao Hui-Lin Ou Tian-Yuan Wu Wen-Sheng Xuan Hai-Peng Zhang Baifu Qin Yu-Bo Zhang Jing-Hao Wang Guo-Cai Wang |
| author_facet | Hai-Yue Zhao Hao-Yue Zhu Qing Tang Qiang Lin Yi-Kun Hao Hui-Lin Ou Tian-Yuan Wu Wen-Sheng Xuan Hai-Peng Zhang Baifu Qin Yu-Bo Zhang Jing-Hao Wang Guo-Cai Wang |
| author_sort | Hai-Yue Zhao |
| collection | DOAJ |
| description | AbstractPouteria caimito is a commercially valuable tropical fruit tree and has medicinal effects in Brazilian folklore. In this thesis, thirteen compounds were isolated for the first time from the fruit of P. caimito by ethanol extraction and various chromatographic column chromatography methods. The thirteen compounds were identified by NMR, HR-ESI-MS and various physicochemical data to contain nine triterpenoids. The results of activity screening experiments showed that compounds 2, 3 and 5 exhibited anti-inflammatory activity, while most of the triterpenoids exhibited anti-RSV, and anti-HSV activity to varying degrees. Based on these results, the content of compound 5 was determined due to its good pharmacological activity to be 13.3250 mg/kg in the fresh fruit. This study scientifically demonstrated the health benefits of consuming P. caimito fruits and also provided new ideas for further development and utilization of P. caimito. It not only has good potential as an anti-inflammatory or antiviral functional food but also can be considered a natural source of triterpenoids. |
| first_indexed | 2024-03-08T13:32:11Z |
| format | Article |
| id | doaj.art-202e6f585dac47c5b79c76394efa990f |
| institution | Directory Open Access Journal |
| issn | 2331-1932 |
| language | English |
| last_indexed | 2024-03-08T13:32:11Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cogent Food & Agriculture |
| spelling | doaj.art-202e6f585dac47c5b79c76394efa990f2024-01-17T07:00:58ZengTaylor & Francis GroupCogent Food & Agriculture2331-19322024-12-0110110.1080/23311932.2023.2298023Anti-inflammatory and antiviral activities of compounds from the fruit of Pouteria caimitoHai-Yue Zhao0Hao-Yue Zhu1Qing Tang2Qiang Lin3Yi-Kun Hao4Hui-Lin Ou5Tian-Yuan Wu6Wen-Sheng Xuan7Hai-Peng Zhang8Baifu Qin9Yu-Bo Zhang10Jing-Hao Wang11Guo-Cai Wang12State Key Laboratory of Bioactive Molecules and Druggability Assessment, and Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, ChinaState Key Laboratory of Bioactive Molecules and Druggability Assessment, and Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, ChinaState Key Laboratory of Bioactive Molecules and Druggability Assessment, and Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, ChinaState Key Laboratory of Bioactive Molecules and Druggability Assessment, and Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, ChinaState Key Laboratory of Bioactive Molecules and Druggability Assessment, and Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, ChinaState Key Laboratory of Bioactive Molecules and Druggability Assessment, and Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, ChinaState Key Laboratory of Bioactive Molecules and Druggability Assessment, and Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, ChinaLandfriend Biological Co, Ltd, Jiangmen, ChinaGuangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, ChinaGuangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, ChinaGuangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, ChinaThe Guangzhou Key Laboratory of Basic and Translational Research on Chronic Diseases, The First Affiliated Hospital, Jinan University, Guangzhou, ChinaState Key Laboratory of Bioactive Molecules and Druggability Assessment, and Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, ChinaAbstractPouteria caimito is a commercially valuable tropical fruit tree and has medicinal effects in Brazilian folklore. In this thesis, thirteen compounds were isolated for the first time from the fruit of P. caimito by ethanol extraction and various chromatographic column chromatography methods. The thirteen compounds were identified by NMR, HR-ESI-MS and various physicochemical data to contain nine triterpenoids. The results of activity screening experiments showed that compounds 2, 3 and 5 exhibited anti-inflammatory activity, while most of the triterpenoids exhibited anti-RSV, and anti-HSV activity to varying degrees. Based on these results, the content of compound 5 was determined due to its good pharmacological activity to be 13.3250 mg/kg in the fresh fruit. This study scientifically demonstrated the health benefits of consuming P. caimito fruits and also provided new ideas for further development and utilization of P. caimito. It not only has good potential as an anti-inflammatory or antiviral functional food but also can be considered a natural source of triterpenoids.https://www.tandfonline.com/doi/10.1080/23311932.2023.2298023Pouteria caimitoanti-inflammatoryantiviral activityM. Luisa Escudero-Gilete, Universidad de Sevilla, SpainAgriculture and Food; Food Chemistry; Substitutes - Food Chemistry; Food Analysis; Nutraceuticals & Functional Foods |
| spellingShingle | Hai-Yue Zhao Hao-Yue Zhu Qing Tang Qiang Lin Yi-Kun Hao Hui-Lin Ou Tian-Yuan Wu Wen-Sheng Xuan Hai-Peng Zhang Baifu Qin Yu-Bo Zhang Jing-Hao Wang Guo-Cai Wang Anti-inflammatory and antiviral activities of compounds from the fruit of Pouteria caimito Cogent Food & Agriculture Pouteria caimito anti-inflammatory antiviral activity M. Luisa Escudero-Gilete, Universidad de Sevilla, Spain Agriculture and Food; Food Chemistry; Substitutes - Food Chemistry; Food Analysis; Nutraceuticals & Functional Foods |
| title | Anti-inflammatory and antiviral activities of compounds from the fruit of Pouteria caimito |
| title_full | Anti-inflammatory and antiviral activities of compounds from the fruit of Pouteria caimito |
| title_fullStr | Anti-inflammatory and antiviral activities of compounds from the fruit of Pouteria caimito |
| title_full_unstemmed | Anti-inflammatory and antiviral activities of compounds from the fruit of Pouteria caimito |
| title_short | Anti-inflammatory and antiviral activities of compounds from the fruit of Pouteria caimito |
| title_sort | anti inflammatory and antiviral activities of compounds from the fruit of pouteria caimito |
| topic | Pouteria caimito anti-inflammatory antiviral activity M. Luisa Escudero-Gilete, Universidad de Sevilla, Spain Agriculture and Food; Food Chemistry; Substitutes - Food Chemistry; Food Analysis; Nutraceuticals & Functional Foods |
| url | https://www.tandfonline.com/doi/10.1080/23311932.2023.2298023 |
| work_keys_str_mv | AT haiyuezhao antiinflammatoryandantiviralactivitiesofcompoundsfromthefruitofpouteriacaimito AT haoyuezhu antiinflammatoryandantiviralactivitiesofcompoundsfromthefruitofpouteriacaimito AT qingtang antiinflammatoryandantiviralactivitiesofcompoundsfromthefruitofpouteriacaimito AT qianglin antiinflammatoryandantiviralactivitiesofcompoundsfromthefruitofpouteriacaimito AT yikunhao antiinflammatoryandantiviralactivitiesofcompoundsfromthefruitofpouteriacaimito AT huilinou antiinflammatoryandantiviralactivitiesofcompoundsfromthefruitofpouteriacaimito AT tianyuanwu antiinflammatoryandantiviralactivitiesofcompoundsfromthefruitofpouteriacaimito AT wenshengxuan antiinflammatoryandantiviralactivitiesofcompoundsfromthefruitofpouteriacaimito AT haipengzhang antiinflammatoryandantiviralactivitiesofcompoundsfromthefruitofpouteriacaimito AT baifuqin antiinflammatoryandantiviralactivitiesofcompoundsfromthefruitofpouteriacaimito AT yubozhang antiinflammatoryandantiviralactivitiesofcompoundsfromthefruitofpouteriacaimito AT jinghaowang antiinflammatoryandantiviralactivitiesofcompoundsfromthefruitofpouteriacaimito AT guocaiwang antiinflammatoryandantiviralactivitiesofcompoundsfromthefruitofpouteriacaimito |