Network of ictal head version in mesial temporal lobe epilepsy
Abstract Objective Ictal head version is a common clinical manifestation of mesial temporal lobe epilepsy (MTLE). Nevertheless, the location of the symptomatogenic zone and the network involved in head version remains unclear. We attempt to explain these problems by analyzing interictal 18FDG‐PET im...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-11-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.1820 |
| _version_ | 1818436998645415936 |
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| author | Yao Wang Xiu Wang Lin Sang Chao Zhang Bao‐tian Zhao Jia‐jie Mo Wen‐han Hu Xiao‐qiu Shao Feng Wang Lin Ai Jian‐guo Zhang Kai Zhang |
| author_facet | Yao Wang Xiu Wang Lin Sang Chao Zhang Bao‐tian Zhao Jia‐jie Mo Wen‐han Hu Xiao‐qiu Shao Feng Wang Lin Ai Jian‐guo Zhang Kai Zhang |
| author_sort | Yao Wang |
| collection | DOAJ |
| description | Abstract Objective Ictal head version is a common clinical manifestation of mesial temporal lobe epilepsy (MTLE). Nevertheless, the location of the symptomatogenic zone and the network involved in head version remains unclear. We attempt to explain these problems by analyzing interictal 18FDG‐PET imaging and ictal stereo‐electroencephalography (SEEG) recordings in MTLE patients. Methods Fifty‐eight patients with MTLE were retrospectively analyzed. The patients were divided into version (+) and (−) groups according to the occurrence of versive head movements. The interictal PET data were compared among 18 healthy controls and the (+) and (−) groups. Furthermore, epileptogenicity index (EI) values and correlations with the onset time of head version were analyzed with SEEG. Results Intergroup comparisons showed that PET differences were observed in the middle temporal neocortex (MTN), posterior temporal neocortex (PTN), supramarginal gyrus (SMG), and inferior parietal lobe (IPL). The EI values in the SMG, MTN, and PTN were significantly higher in the version (+) group than in the version (−) group. A linear relationship was observed between head version onset and ipsilateral onset time in the SMG, orbitofrontal cortex (OFC), MTN, and PTN. A linear relationship was observed between EI, the difference between version onset and temporal neocortex onset, and the y‐axis of the MNI coordinate. Conclusion The generation of ictal head version contributes to the propagation of ictal discharges to the intraparietal sulcus (IPS) area. The network of version originates from a mesial temporal lobe structure, passes through the MTN, PTN, and SMG, and likely ends at the IPS. |
| first_indexed | 2024-12-14T17:17:41Z |
| format | Article |
| id | doaj.art-202e96336b30448caea0a73798bf5d98 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-12-14T17:17:41Z |
| publishDate | 2020-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-202e96336b30448caea0a73798bf5d982022-12-21T22:53:24ZengWileyBrain and Behavior2162-32792020-11-011011n/an/a10.1002/brb3.1820Network of ictal head version in mesial temporal lobe epilepsyYao Wang0Xiu Wang1Lin Sang2Chao Zhang3Bao‐tian Zhao4Jia‐jie Mo5Wen‐han Hu6Xiao‐qiu Shao7Feng Wang8Lin Ai9Jian‐guo Zhang10Kai Zhang11Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartment of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing ChinaEpilepsy Center Peking University First Hospital Fengtai Hospital Beijing ChinaDepartment of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartment of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartment of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing ChinaBeijing Key Laboratory of Neurostimulation Beijing ChinaDepartment of Neurology Beijing Tiantan HospitalCapital Medical University Beijing ChinaDepartment of Neurosurgery General Hospital of Ningxia Medical University Ningxia ChinaDepartment of Nuclear Medicine Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartment of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartment of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing ChinaAbstract Objective Ictal head version is a common clinical manifestation of mesial temporal lobe epilepsy (MTLE). Nevertheless, the location of the symptomatogenic zone and the network involved in head version remains unclear. We attempt to explain these problems by analyzing interictal 18FDG‐PET imaging and ictal stereo‐electroencephalography (SEEG) recordings in MTLE patients. Methods Fifty‐eight patients with MTLE were retrospectively analyzed. The patients were divided into version (+) and (−) groups according to the occurrence of versive head movements. The interictal PET data were compared among 18 healthy controls and the (+) and (−) groups. Furthermore, epileptogenicity index (EI) values and correlations with the onset time of head version were analyzed with SEEG. Results Intergroup comparisons showed that PET differences were observed in the middle temporal neocortex (MTN), posterior temporal neocortex (PTN), supramarginal gyrus (SMG), and inferior parietal lobe (IPL). The EI values in the SMG, MTN, and PTN were significantly higher in the version (+) group than in the version (−) group. A linear relationship was observed between head version onset and ipsilateral onset time in the SMG, orbitofrontal cortex (OFC), MTN, and PTN. A linear relationship was observed between EI, the difference between version onset and temporal neocortex onset, and the y‐axis of the MNI coordinate. Conclusion The generation of ictal head version contributes to the propagation of ictal discharges to the intraparietal sulcus (IPS) area. The network of version originates from a mesial temporal lobe structure, passes through the MTN, PTN, and SMG, and likely ends at the IPS.https://doi.org/10.1002/brb3.1820epileptogenicity indexhead versionnetworkpositron emission tomographytemporal lobe epilepsy |
| spellingShingle | Yao Wang Xiu Wang Lin Sang Chao Zhang Bao‐tian Zhao Jia‐jie Mo Wen‐han Hu Xiao‐qiu Shao Feng Wang Lin Ai Jian‐guo Zhang Kai Zhang Network of ictal head version in mesial temporal lobe epilepsy Brain and Behavior epileptogenicity index head version network positron emission tomography temporal lobe epilepsy |
| title | Network of ictal head version in mesial temporal lobe epilepsy |
| title_full | Network of ictal head version in mesial temporal lobe epilepsy |
| title_fullStr | Network of ictal head version in mesial temporal lobe epilepsy |
| title_full_unstemmed | Network of ictal head version in mesial temporal lobe epilepsy |
| title_short | Network of ictal head version in mesial temporal lobe epilepsy |
| title_sort | network of ictal head version in mesial temporal lobe epilepsy |
| topic | epileptogenicity index head version network positron emission tomography temporal lobe epilepsy |
| url | https://doi.org/10.1002/brb3.1820 |
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