Effects of Compound Honey Syrup (Ma-ol-asal) on Polycystic Ovary Syndrome (PCOS) Induced by Estradiol Valerate in Female Rats
Introduction: Polycystic ovary syndrome affects 5-10% of women of reproductive age and is characterized by irregular menstruation, hyperandrogenism, and ovarian cysts. Iranian traditional medicine products can be effective in treatment of this syndrome. This study was performed with aim to evaluate...
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Mashhad University of Medical Sciences
2021-02-01
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| Series: | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
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| Online Access: | https://ijogi.mums.ac.ir/article_17823_ca3baf38ad3ca50451bfa2ff536342e0.pdf |
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| author | Mojgan Tansaz Maryam Bahman Mahmoud Khodadoost Seyyed Shamsadin Athari Saadat Ghafarzadeh Hanieh Kashafroodi Rasool Choopani |
| author_facet | Mojgan Tansaz Maryam Bahman Mahmoud Khodadoost Seyyed Shamsadin Athari Saadat Ghafarzadeh Hanieh Kashafroodi Rasool Choopani |
| author_sort | Mojgan Tansaz |
| collection | DOAJ |
| description | Introduction: Polycystic ovary syndrome affects 5-10% of women of reproductive age and is characterized by irregular menstruation, hyperandrogenism, and ovarian cysts. Iranian traditional medicine products can be effective in treatment of this syndrome. This study was performed with aim to evaluate the effect of compound honey syrup on the polycystic ovary syndrome induced by estradiol valerate in female rats. Methods: In this experimental study conducted by traditional medicine and matria medica research center of Shahid Beheshti University of Medical Sciences in animal laboratory of Shahid Beheshti University of Medical Sciences on female rats in 2017, the compound honey syrup (Ma-ol-asal) (containing honey, cinnamon, ginger, saffron, cardamom, galangal, nutmeg, mace and mastic) was used. Thirty female rats were classified into five groups of cases: negative control, positive control, and three treatment groups (receiving two doses of compound honey syrup (1ml/kg and 2ml/kg) and metformin). Polycystic ovary syndrome was induced by injection of Estradiol valerate. At the end of intervention, the rats were euthanized, hormones were measured, and the ovarian histology was examined. Data were analyzed by SPSS software (version 24) and Kruskal-Wallis and Dunn-Bonferroni tests. p < 0.05 was considered statistically significant. Results: At the end of the study, weights of ovaries in the metformin and Ma-ol-asal 2 groups were higher than the untreated group. There was no change in body weight or abdominal fat. There was a significant increase in levels of progesterone in three treatment groups (P=0.002) and significant reduction of estrogen in the metformin group compared to the untreated group (P=0.021). There was significant reduction of number of ovary cysts in Ma-ol-asal 1 group (P=0.001), and significant increase in the number of Corpus luteum, and antral follicles in Ma-ol-asal 1 and 2 groups compared to the untreated group (P=0.010). The number of graph follicles did not differ significantly in the groups (P=0.083). Conclusion: Compound honey syrup was effective in improving hormonal and histological status in polycystic ovary syndrome as much as metformin and was more effective in some cases. |
| first_indexed | 2024-04-11T07:07:29Z |
| format | Article |
| id | doaj.art-202eda193c7745288e928a0e497d3265 |
| institution | Directory Open Access Journal |
| issn | 1680-2993 2008-2363 |
| language | fas |
| last_indexed | 2024-04-11T07:07:29Z |
| publishDate | 2021-02-01 |
| publisher | Mashhad University of Medical Sciences |
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| series | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
| spelling | doaj.art-202eda193c7745288e928a0e497d32652022-12-22T04:38:21ZfasMashhad University of Medical SciencesMajallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān1680-29932008-23632021-02-012312132410.22038/ijogi.2021.1782317823Effects of Compound Honey Syrup (Ma-ol-asal) on Polycystic Ovary Syndrome (PCOS) Induced by Estradiol Valerate in Female RatsMojgan Tansaz0Maryam Bahman1Mahmoud Khodadoost2Seyyed Shamsadin Athari3Saadat Ghafarzadeh4Hanieh Kashafroodi5Rasool Choopani6Traditional Medicine & Matria Medica Research Center, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Assistant Professor, Department of Traditional Medicine, School of TraditionalTraditional Medicine & Matria Medica Research Center, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Ph.D of Traditional Medicine, School of Traditional Medicine, Qom University ofAssociate Professor, Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Assistant Professor, Department of Immunology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.Ph.D of Veterinary Pathology, Department of Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.Traditional Medicine & Matria Medica Research Center, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Traditional Medicine & Matria Medica Research Center, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Assistant Professor, Department of Traditional Medicine, School of TraditionalIntroduction: Polycystic ovary syndrome affects 5-10% of women of reproductive age and is characterized by irregular menstruation, hyperandrogenism, and ovarian cysts. Iranian traditional medicine products can be effective in treatment of this syndrome. This study was performed with aim to evaluate the effect of compound honey syrup on the polycystic ovary syndrome induced by estradiol valerate in female rats. Methods: In this experimental study conducted by traditional medicine and matria medica research center of Shahid Beheshti University of Medical Sciences in animal laboratory of Shahid Beheshti University of Medical Sciences on female rats in 2017, the compound honey syrup (Ma-ol-asal) (containing honey, cinnamon, ginger, saffron, cardamom, galangal, nutmeg, mace and mastic) was used. Thirty female rats were classified into five groups of cases: negative control, positive control, and three treatment groups (receiving two doses of compound honey syrup (1ml/kg and 2ml/kg) and metformin). Polycystic ovary syndrome was induced by injection of Estradiol valerate. At the end of intervention, the rats were euthanized, hormones were measured, and the ovarian histology was examined. Data were analyzed by SPSS software (version 24) and Kruskal-Wallis and Dunn-Bonferroni tests. p < 0.05 was considered statistically significant. Results: At the end of the study, weights of ovaries in the metformin and Ma-ol-asal 2 groups were higher than the untreated group. There was no change in body weight or abdominal fat. There was a significant increase in levels of progesterone in three treatment groups (P=0.002) and significant reduction of estrogen in the metformin group compared to the untreated group (P=0.021). There was significant reduction of number of ovary cysts in Ma-ol-asal 1 group (P=0.001), and significant increase in the number of Corpus luteum, and antral follicles in Ma-ol-asal 1 and 2 groups compared to the untreated group (P=0.010). The number of graph follicles did not differ significantly in the groups (P=0.083). Conclusion: Compound honey syrup was effective in improving hormonal and histological status in polycystic ovary syndrome as much as metformin and was more effective in some cases.https://ijogi.mums.ac.ir/article_17823_ca3baf38ad3ca50451bfa2ff536342e0.pdfcompound honey syrupmetabolic syndromepolycystic ovary syndrometraditional persian medicine |
| spellingShingle | Mojgan Tansaz Maryam Bahman Mahmoud Khodadoost Seyyed Shamsadin Athari Saadat Ghafarzadeh Hanieh Kashafroodi Rasool Choopani Effects of Compound Honey Syrup (Ma-ol-asal) on Polycystic Ovary Syndrome (PCOS) Induced by Estradiol Valerate in Female Rats Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān compound honey syrup metabolic syndrome polycystic ovary syndrome traditional persian medicine |
| title | Effects of Compound Honey Syrup (Ma-ol-asal) on Polycystic Ovary Syndrome (PCOS) Induced by Estradiol Valerate in Female Rats |
| title_full | Effects of Compound Honey Syrup (Ma-ol-asal) on Polycystic Ovary Syndrome (PCOS) Induced by Estradiol Valerate in Female Rats |
| title_fullStr | Effects of Compound Honey Syrup (Ma-ol-asal) on Polycystic Ovary Syndrome (PCOS) Induced by Estradiol Valerate in Female Rats |
| title_full_unstemmed | Effects of Compound Honey Syrup (Ma-ol-asal) on Polycystic Ovary Syndrome (PCOS) Induced by Estradiol Valerate in Female Rats |
| title_short | Effects of Compound Honey Syrup (Ma-ol-asal) on Polycystic Ovary Syndrome (PCOS) Induced by Estradiol Valerate in Female Rats |
| title_sort | effects of compound honey syrup ma ol asal on polycystic ovary syndrome pcos induced by estradiol valerate in female rats |
| topic | compound honey syrup metabolic syndrome polycystic ovary syndrome traditional persian medicine |
| url | https://ijogi.mums.ac.ir/article_17823_ca3baf38ad3ca50451bfa2ff536342e0.pdf |
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