Astrocytes display ultrastructural alterations and heterogeneity in the hippocampus of aged APP-PS1 mice and human post-mortem brain samples

Astrocytes display ultrastructural alterations and heterogeneity in the hippocampus of aged APP-PS1 mice and human post-mortem brain samples

Abstract The past decade has witnessed increasing evidence for a crucial role played by glial cells, notably astrocytes, in Alzheimer’s disease (AD). To provide novel insights into the roles of astrocytes in the pathophysiology of AD, we performed a quantitative ultrastructural characterization of t...

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Bibliographic Details
Main Authors: Marie-Kim St-Pierre, Micaël Carrier, Fernando González Ibáñez, Mohammadparsa Khakpour, Marie-Josée Wallman, Martin Parent, Marie-Ève Tremblay
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Neuroinflammation
Subjects:
Astrocytes
Heterogeneity
Dark astrocytes
Ultrastructure
Aging
Alzheimer’s disease
Online Access:https://doi.org/10.1186/s12974-023-02752-7

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