Co-registration Comparison of On-Scalp Magnetoencephalography and Magnetic Resonance Imaging
Magnetoencephalography (MEG) can non-invasively measure the electromagnetic activity of the brain. A new type of MEG, on-scalp MEG, has attracted the attention of researchers recently. Compared to the conventional SQUID-MEG, on-scalp MEG constructed with optically pumped magnetometers is wearable an...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2021.706785/full |
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| author | Fuzhi Cao Nan An Weinan Xu Wenli Wang Yanfei Yang Min Xiang Min Xiang Yang Gao Yang Gao Xiaolin Ning Xiaolin Ning |
| author_facet | Fuzhi Cao Nan An Weinan Xu Wenli Wang Yanfei Yang Min Xiang Min Xiang Yang Gao Yang Gao Xiaolin Ning Xiaolin Ning |
| author_sort | Fuzhi Cao |
| collection | DOAJ |
| description | Magnetoencephalography (MEG) can non-invasively measure the electromagnetic activity of the brain. A new type of MEG, on-scalp MEG, has attracted the attention of researchers recently. Compared to the conventional SQUID-MEG, on-scalp MEG constructed with optically pumped magnetometers is wearable and has a high signal-to-noise ratio. While the co-registration between MEG and magnetic resonance imaging (MRI) significantly influences the source localization accuracy, co-registration error requires assessment, and quantification. Recent studies have evaluated the co-registration error of on-scalp MEG mainly based on the surface fit error or the repeatability error of different measurements, which do not reflect the true co-registration error. In this study, a three-dimensional-printed reference phantom was constructed to provide the ground truth of MEG sensor locations and orientations relative to MRI. The co-registration performances of commonly used three devices—electromagnetic digitization system, structured-light scanner, and laser scanner—were compared and quantified by the indices of final co-registration errors in the reference phantom and human experiments. Furthermore, the influence of the co-registration error on the performance of source localization was analyzed via simulations. The laser scanner had the best co-registration accuracy (rotation error of 0.23° and translation error of 0.76 mm based on the phantom experiment), whereas the structured-light scanner had the best cost performance. The results of this study provide recommendations and precautions for researchers regarding selecting and using an appropriate device for the co-registration of on-scalp MEG and MRI. |
| first_indexed | 2024-12-19T22:39:41Z |
| format | Article |
| id | doaj.art-20311da18e23493eb63f850b511c139c |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-19T22:39:41Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-20311da18e23493eb63f850b511c139c2022-12-21T20:03:07ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2021-08-011510.3389/fnins.2021.706785706785Co-registration Comparison of On-Scalp Magnetoencephalography and Magnetic Resonance ImagingFuzhi Cao0Nan An1Weinan Xu2Wenli Wang3Yanfei Yang4Min Xiang5Min Xiang6Yang Gao7Yang Gao8Xiaolin Ning9Xiaolin Ning10School of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing, ChinaSchool of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing, ChinaSchool of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing, ChinaSchool of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing, ChinaSchool of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing, ChinaHangzhou Innovation Institute, Beihang University, Hangzhou, ChinaResearch Institute for Frontier Science, Beihang University, Beijing, ChinaHangzhou Innovation Institute, Beihang University, Hangzhou, ChinaBeijing Academy of Quantum Information Sciences, Beijing, ChinaHangzhou Innovation Institute, Beihang University, Hangzhou, ChinaResearch Institute for Frontier Science, Beihang University, Beijing, ChinaMagnetoencephalography (MEG) can non-invasively measure the electromagnetic activity of the brain. A new type of MEG, on-scalp MEG, has attracted the attention of researchers recently. Compared to the conventional SQUID-MEG, on-scalp MEG constructed with optically pumped magnetometers is wearable and has a high signal-to-noise ratio. While the co-registration between MEG and magnetic resonance imaging (MRI) significantly influences the source localization accuracy, co-registration error requires assessment, and quantification. Recent studies have evaluated the co-registration error of on-scalp MEG mainly based on the surface fit error or the repeatability error of different measurements, which do not reflect the true co-registration error. In this study, a three-dimensional-printed reference phantom was constructed to provide the ground truth of MEG sensor locations and orientations relative to MRI. The co-registration performances of commonly used three devices—electromagnetic digitization system, structured-light scanner, and laser scanner—were compared and quantified by the indices of final co-registration errors in the reference phantom and human experiments. Furthermore, the influence of the co-registration error on the performance of source localization was analyzed via simulations. The laser scanner had the best co-registration accuracy (rotation error of 0.23° and translation error of 0.76 mm based on the phantom experiment), whereas the structured-light scanner had the best cost performance. The results of this study provide recommendations and precautions for researchers regarding selecting and using an appropriate device for the co-registration of on-scalp MEG and MRI.https://www.frontiersin.org/articles/10.3389/fnins.2021.706785/fullmagnetoencephalographyon-scalp MEGco-registrationreference phantomlaser scanner |
| spellingShingle | Fuzhi Cao Nan An Weinan Xu Wenli Wang Yanfei Yang Min Xiang Min Xiang Yang Gao Yang Gao Xiaolin Ning Xiaolin Ning Co-registration Comparison of On-Scalp Magnetoencephalography and Magnetic Resonance Imaging Frontiers in Neuroscience magnetoencephalography on-scalp MEG co-registration reference phantom laser scanner |
| title | Co-registration Comparison of On-Scalp Magnetoencephalography and Magnetic Resonance Imaging |
| title_full | Co-registration Comparison of On-Scalp Magnetoencephalography and Magnetic Resonance Imaging |
| title_fullStr | Co-registration Comparison of On-Scalp Magnetoencephalography and Magnetic Resonance Imaging |
| title_full_unstemmed | Co-registration Comparison of On-Scalp Magnetoencephalography and Magnetic Resonance Imaging |
| title_short | Co-registration Comparison of On-Scalp Magnetoencephalography and Magnetic Resonance Imaging |
| title_sort | co registration comparison of on scalp magnetoencephalography and magnetic resonance imaging |
| topic | magnetoencephalography on-scalp MEG co-registration reference phantom laser scanner |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2021.706785/full |
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