Assessment of genetically modified maize DP202216 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2019‐159)
Abstract Genetically modified maize DP202216 was developed to confer tolerance to glufosinate‐ammonium‐containing herbicides and to provide an opportunity for yield enhancement under field conditions. These properties were achieved by introducing the mo‐pat and zmm28 expression cassettes. The molecu...
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| Format: | Article |
| Language: | English |
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Wiley
2024-03-01
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| Series: | EFSA Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.2903/j.efsa.2024.8655 |
| _version_ | 1797235658142515200 |
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| author | EFSA Panel on Genetically Modified Organisms (GMO) Ewen Mullins Jean‐Louis Bresson Tamas Dalmay Ian Crawford Dewhurst Michelle M. Epstein Leslie George Firbank Philippe Guerche Jan Hejatko Francisco Javier Moreno Hanspeter Naegeli Fabien Nogué Nils Rostoks Jose Juan Sánchez Serrano Giovanni Savoini Eve Veromann Fabio Veronesi Michele Ardizzone Ana M. Camargo Giacomo De Sanctis Silvia Federici Antonio Fernandez Andrea Gennaro José Ángel Gómez Ruiz Tilemachos Goumperis Paschalina Grammatikou Dafni Maria Kagkli Paolo Lenzi Franco Maria Neri Nikoletta Papadopoulou Tommaso Raffaello |
| author_facet | EFSA Panel on Genetically Modified Organisms (GMO) Ewen Mullins Jean‐Louis Bresson Tamas Dalmay Ian Crawford Dewhurst Michelle M. Epstein Leslie George Firbank Philippe Guerche Jan Hejatko Francisco Javier Moreno Hanspeter Naegeli Fabien Nogué Nils Rostoks Jose Juan Sánchez Serrano Giovanni Savoini Eve Veromann Fabio Veronesi Michele Ardizzone Ana M. Camargo Giacomo De Sanctis Silvia Federici Antonio Fernandez Andrea Gennaro José Ángel Gómez Ruiz Tilemachos Goumperis Paschalina Grammatikou Dafni Maria Kagkli Paolo Lenzi Franco Maria Neri Nikoletta Papadopoulou Tommaso Raffaello |
| author_sort | EFSA Panel on Genetically Modified Organisms (GMO) |
| collection | DOAJ |
| description | Abstract Genetically modified maize DP202216 was developed to confer tolerance to glufosinate‐ammonium‐containing herbicides and to provide an opportunity for yield enhancement under field conditions. These properties were achieved by introducing the mo‐pat and zmm28 expression cassettes. The molecular characterisation data and bioinformatic analyses do not identify issues requiring food/feed safety assessment. None of the identified differences in the agronomic/phenotypic and compositional characteristics tested between maize DP202216 and its comparator needs further assessment, except for the levels of stearic acid (C18:0), which do not raise nutritional and safety concerns. The GMO Panel does not identify safety concerns regarding the toxicity and allergenicity of the PAT and ZMM28 proteins as expressed in maize DP202216, and finds no evidence that the genetic modification would change the overall allergenicity of maize DP202216. In the context of this application, the consumption of food and feed from maize DP202216 does not represent a nutritional concern in humans and animals. The GMO Panel concludes that maize DP202216 is as safe as the comparator and non‐GM reference varieties tested, and no post‐market monitoring of food/feed is considered necessary. In the case of accidental release of viable maize DP202216 grains into the environment, this would not raise environmental safety concerns. The post‐market environmental monitoring plan and reporting intervals are in line with the intended uses of maize DP202216. The GMO Panel concludes that maize DP202216 is as safe as its comparator and the tested non‐GM reference varieties with respect to potential effects on human and animal health and the environment. |
| first_indexed | 2024-04-24T16:51:27Z |
| format | Article |
| id | doaj.art-2031338508bf45fa9262c2920869e373 |
| institution | Directory Open Access Journal |
| issn | 1831-4732 |
| language | English |
| last_indexed | 2024-04-24T16:51:27Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | EFSA Journal |
| spelling | doaj.art-2031338508bf45fa9262c2920869e3732024-03-29T03:10:39ZengWileyEFSA Journal1831-47322024-03-01223n/an/a10.2903/j.efsa.2024.8655Assessment of genetically modified maize DP202216 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2019‐159)EFSA Panel on Genetically Modified Organisms (GMO)Ewen MullinsJean‐Louis BressonTamas DalmayIan Crawford DewhurstMichelle M. EpsteinLeslie George FirbankPhilippe GuercheJan HejatkoFrancisco Javier MorenoHanspeter NaegeliFabien NoguéNils RostoksJose Juan Sánchez SerranoGiovanni SavoiniEve VeromannFabio VeronesiMichele ArdizzoneAna M. CamargoGiacomo De SanctisSilvia FedericiAntonio FernandezAndrea GennaroJosé Ángel Gómez RuizTilemachos GoumperisPaschalina GrammatikouDafni Maria KagkliPaolo LenziFranco Maria NeriNikoletta PapadopoulouTommaso RaffaelloAbstract Genetically modified maize DP202216 was developed to confer tolerance to glufosinate‐ammonium‐containing herbicides and to provide an opportunity for yield enhancement under field conditions. These properties were achieved by introducing the mo‐pat and zmm28 expression cassettes. The molecular characterisation data and bioinformatic analyses do not identify issues requiring food/feed safety assessment. None of the identified differences in the agronomic/phenotypic and compositional characteristics tested between maize DP202216 and its comparator needs further assessment, except for the levels of stearic acid (C18:0), which do not raise nutritional and safety concerns. The GMO Panel does not identify safety concerns regarding the toxicity and allergenicity of the PAT and ZMM28 proteins as expressed in maize DP202216, and finds no evidence that the genetic modification would change the overall allergenicity of maize DP202216. In the context of this application, the consumption of food and feed from maize DP202216 does not represent a nutritional concern in humans and animals. The GMO Panel concludes that maize DP202216 is as safe as the comparator and non‐GM reference varieties tested, and no post‐market monitoring of food/feed is considered necessary. In the case of accidental release of viable maize DP202216 grains into the environment, this would not raise environmental safety concerns. The post‐market environmental monitoring plan and reporting intervals are in line with the intended uses of maize DP202216. The GMO Panel concludes that maize DP202216 is as safe as its comparator and the tested non‐GM reference varieties with respect to potential effects on human and animal health and the environment.https://doi.org/10.2903/j.efsa.2024.8655DP202216genetic engineeringGMimport and processingmaize (Zea mays)PAT |
| spellingShingle | EFSA Panel on Genetically Modified Organisms (GMO) Ewen Mullins Jean‐Louis Bresson Tamas Dalmay Ian Crawford Dewhurst Michelle M. Epstein Leslie George Firbank Philippe Guerche Jan Hejatko Francisco Javier Moreno Hanspeter Naegeli Fabien Nogué Nils Rostoks Jose Juan Sánchez Serrano Giovanni Savoini Eve Veromann Fabio Veronesi Michele Ardizzone Ana M. Camargo Giacomo De Sanctis Silvia Federici Antonio Fernandez Andrea Gennaro José Ángel Gómez Ruiz Tilemachos Goumperis Paschalina Grammatikou Dafni Maria Kagkli Paolo Lenzi Franco Maria Neri Nikoletta Papadopoulou Tommaso Raffaello Assessment of genetically modified maize DP202216 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2019‐159) EFSA Journal DP202216 genetic engineering GM import and processing maize (Zea mays) PAT |
| title | Assessment of genetically modified maize DP202216 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2019‐159) |
| title_full | Assessment of genetically modified maize DP202216 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2019‐159) |
| title_fullStr | Assessment of genetically modified maize DP202216 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2019‐159) |
| title_full_unstemmed | Assessment of genetically modified maize DP202216 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2019‐159) |
| title_short | Assessment of genetically modified maize DP202216 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2019‐159) |
| title_sort | assessment of genetically modified maize dp202216 for food and feed uses under regulation ec no 1829 2003 application efsa gmo nl 2019 159 |
| topic | DP202216 genetic engineering GM import and processing maize (Zea mays) PAT |
| url | https://doi.org/10.2903/j.efsa.2024.8655 |
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