THE IMPORTANCE OF THE ERYTHROCYTES OSMOTIC FRAGILITY TEST PERFORMED IN CHILDREN WITH INDIRECT HYPERBILIRUB1NEMIA
The osmotic fragility test of erythrocytes is useful in the diagnosis of different types of hereditary hemolytic anemias followed with hyperbilirubinemia. Hemolytic anemias, characterized by accelerated destruction of red blood cells, are usually the consequence of many metabolic abnormalities like...
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| Format: | Article |
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University in Nis, Faculty of Medicine
2005-07-01
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| Series: | Acta Medica Medianae |
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| Online Access: | http://publisher.medfak.ni.ac.rs/2005-html/3-broj/Znacaj%20izvodenja%20testa%20osmotske%20....pdf |
| _version_ | 1819242006205956096 |
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| author | Ivana Stojanović Dušan Sokolović Gordana Kostić Tatjana Jevtović Gordana Bjelaković |
| author_facet | Ivana Stojanović Dušan Sokolović Gordana Kostić Tatjana Jevtović Gordana Bjelaković |
| author_sort | Ivana Stojanović |
| collection | DOAJ |
| description | The osmotic fragility test of erythrocytes is useful in the diagnosis of different types of hereditary hemolytic anemias followed with hyperbilirubinemia. Hemolytic anemias, characterized by accelerated destruction of red blood cells, are usually the consequence of many metabolic abnormalities like cellular membrane defect, erythrocyte enzymes defect or hemoglobin abnormalities – hemoglobinopathies. The object of our study was to assess the relationship between osmotic fragility test of erythrocytes and severity of indirect hyperbilirubinemia in some inherited erythrocytes’ disorders. We did the osmotic fragility test of erythrocytes by using Dacie, s method with normal values of erythrocytes hemolysis between 0,48 to 0,34% NaCl (minimal to maximal hemolysis). In hereditary spherocytosis, fragility of erythrocytes was increased (min. at 0,50 % NaCl to max. 0,44 % NaCl) . In the child with β- thalassemia and cycle cell anemia erythrocytes fragility was decreased (min . at 0,42 to max. 0,32 % NaCl), that is 0,40% min. of hemolysis and 0,34% max. hemolysis in the second case. In newborn infants with high levels of indirect bilirubin in serum as a cause of physiological jaundice, the osmotic fragility test was within a normal range. Our findings point out the diagnostic value of osmotic fragility test in assessing patients with the indirect hyperbilirubinemia. This simple and important diagnostic test can be performed in small laboratories. |
| first_indexed | 2024-12-23T14:32:56Z |
| format | Article |
| id | doaj.art-2033766fd00b4c55a61986ee2942cc82 |
| institution | Directory Open Access Journal |
| issn | 0365-4478 |
| language | English |
| last_indexed | 2024-12-23T14:32:56Z |
| publishDate | 2005-07-01 |
| publisher | University in Nis, Faculty of Medicine |
| record_format | Article |
| series | Acta Medica Medianae |
| spelling | doaj.art-2033766fd00b4c55a61986ee2942cc822022-12-21T17:43:26ZengUniversity in Nis, Faculty of MedicineActa Medica Medianae0365-44782005-07-014434751THE IMPORTANCE OF THE ERYTHROCYTES OSMOTIC FRAGILITY TEST PERFORMED IN CHILDREN WITH INDIRECT HYPERBILIRUB1NEMIAIvana StojanovićDušan SokolovićGordana KostićTatjana JevtovićGordana BjelakovićThe osmotic fragility test of erythrocytes is useful in the diagnosis of different types of hereditary hemolytic anemias followed with hyperbilirubinemia. Hemolytic anemias, characterized by accelerated destruction of red blood cells, are usually the consequence of many metabolic abnormalities like cellular membrane defect, erythrocyte enzymes defect or hemoglobin abnormalities – hemoglobinopathies. The object of our study was to assess the relationship between osmotic fragility test of erythrocytes and severity of indirect hyperbilirubinemia in some inherited erythrocytes’ disorders. We did the osmotic fragility test of erythrocytes by using Dacie, s method with normal values of erythrocytes hemolysis between 0,48 to 0,34% NaCl (minimal to maximal hemolysis). In hereditary spherocytosis, fragility of erythrocytes was increased (min. at 0,50 % NaCl to max. 0,44 % NaCl) . In the child with β- thalassemia and cycle cell anemia erythrocytes fragility was decreased (min . at 0,42 to max. 0,32 % NaCl), that is 0,40% min. of hemolysis and 0,34% max. hemolysis in the second case. In newborn infants with high levels of indirect bilirubin in serum as a cause of physiological jaundice, the osmotic fragility test was within a normal range. Our findings point out the diagnostic value of osmotic fragility test in assessing patients with the indirect hyperbilirubinemia. This simple and important diagnostic test can be performed in small laboratories.http://publisher.medfak.ni.ac.rs/2005-html/3-broj/Znacaj%20izvodenja%20testa%20osmotske%20....pdfosmotic fragility testerythrocyteshyperbilirubinemiachildhood |
| spellingShingle | Ivana Stojanović Dušan Sokolović Gordana Kostić Tatjana Jevtović Gordana Bjelaković THE IMPORTANCE OF THE ERYTHROCYTES OSMOTIC FRAGILITY TEST PERFORMED IN CHILDREN WITH INDIRECT HYPERBILIRUB1NEMIA Acta Medica Medianae osmotic fragility test erythrocytes hyperbilirubinemia childhood |
| title | THE IMPORTANCE OF THE ERYTHROCYTES OSMOTIC FRAGILITY TEST PERFORMED IN CHILDREN WITH INDIRECT HYPERBILIRUB1NEMIA |
| title_full | THE IMPORTANCE OF THE ERYTHROCYTES OSMOTIC FRAGILITY TEST PERFORMED IN CHILDREN WITH INDIRECT HYPERBILIRUB1NEMIA |
| title_fullStr | THE IMPORTANCE OF THE ERYTHROCYTES OSMOTIC FRAGILITY TEST PERFORMED IN CHILDREN WITH INDIRECT HYPERBILIRUB1NEMIA |
| title_full_unstemmed | THE IMPORTANCE OF THE ERYTHROCYTES OSMOTIC FRAGILITY TEST PERFORMED IN CHILDREN WITH INDIRECT HYPERBILIRUB1NEMIA |
| title_short | THE IMPORTANCE OF THE ERYTHROCYTES OSMOTIC FRAGILITY TEST PERFORMED IN CHILDREN WITH INDIRECT HYPERBILIRUB1NEMIA |
| title_sort | importance of the erythrocytes osmotic fragility test performed in children with indirect hyperbilirub1nemia |
| topic | osmotic fragility test erythrocytes hyperbilirubinemia childhood |
| url | http://publisher.medfak.ni.ac.rs/2005-html/3-broj/Znacaj%20izvodenja%20testa%20osmotske%20....pdf |
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