Nano Drug Delivery Platforms for Dental Application: Infection Control and TMJ Management—A Review
The oral cavity is an intricate environment subjected to various chemical, physical, and thermal injuries. The effectiveness of the local and systemically administered drugs is limited mainly due to their toxicities and poor oral bioavailability that leads to the limited effectiveness of the drugs i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/13/23/4175 |
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| author | Abhishek Lal Mohammad Khursheed Alam Naseer Ahmed Afsheen Maqsood Ruba K. Al-Qaisi Deepti Shrivastava Zainab Ali Alkhalaf Amal Mohamed Alanazi Hasna Rasheed Alshubrmi Mohammed G. Sghaireen Kumar Chandan Srivastava |
| author_facet | Abhishek Lal Mohammad Khursheed Alam Naseer Ahmed Afsheen Maqsood Ruba K. Al-Qaisi Deepti Shrivastava Zainab Ali Alkhalaf Amal Mohamed Alanazi Hasna Rasheed Alshubrmi Mohammed G. Sghaireen Kumar Chandan Srivastava |
| author_sort | Abhishek Lal |
| collection | DOAJ |
| description | The oral cavity is an intricate environment subjected to various chemical, physical, and thermal injuries. The effectiveness of the local and systemically administered drugs is limited mainly due to their toxicities and poor oral bioavailability that leads to the limited effectiveness of the drugs in the target tissues. To address these issues, nanoparticle drug delivery systems based on metals, liposomes, polymeric particles, and core shells have been developed in recent years. Nano drug delivery systems have applications in the treatment of patients suffering from temporomandibular joint disorders such as preventing degeneration of cartilage in patients suffering from rheumatoid arthritis and osteoarthritis and alleviating the pain along with it. The antibacterial dental applications of nano-drug delivery systems such as silver and copper-based nanoparticles include these agents used to arrest dental caries, multiple steps in root canal treatment, and patients suffering from periodontitis. Nanoparticles have been used in adjunct with antifungals to treat oral fungal infections such as candida albicans in denture wearers. Acyclovir being the most commonly used antiviral has been used in combination with nanoparticles against an array of viral infections such as the herpes simplex virus. Nanoparticles based combination agents offer more favorable drug release in a controlled manner along with efficient delivery at the site of action. This review presents an updated overview of the recently developed nanoparticles delivery systems for the management of temporomandibular joint disorders along with the treatment of different oral infections. |
| first_indexed | 2024-03-10T04:46:09Z |
| format | Article |
| id | doaj.art-2034504d48c04a9d830bb718172994a1 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T04:46:09Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-2034504d48c04a9d830bb718172994a12023-11-23T02:54:01ZengMDPI AGPolymers2073-43602021-11-011323417510.3390/polym13234175Nano Drug Delivery Platforms for Dental Application: Infection Control and TMJ Management—A ReviewAbhishek Lal0Mohammad Khursheed Alam1Naseer Ahmed2Afsheen Maqsood3Ruba K. Al-Qaisi4Deepti Shrivastava5Zainab Ali Alkhalaf6Amal Mohamed Alanazi7Hasna Rasheed Alshubrmi8Mohammed G. Sghaireen9Kumar Chandan Srivastava10Department of Prosthodontic, Altamash Institute of Dental Medicine, Karachi 75500, PakistanOrthodontics, Department of Preventive Dentistry, College of Dentistry, Jouf University, Sakaka 72345, Saudi ArabiaDepartment of Prosthodontic, Altamash Institute of Dental Medicine, Karachi 75500, PakistanDepartment of Oral Pathology, Bahria University Dental College, Karachi 75530, PakistanProsthodontic Dentistry Department, Jordanian Royal Medical Services, Amman 11180, JordanPeriodontics, Department of Preventive Dentistry, College of Dentistry, Jouf University, Sakaka 72345, Saudi ArabiaProsthodontic Dentistry Department, College of Dentistry, Jouf University, Sakaka 72345, Saudi ArabiaProsthodontic Dentistry Department, College of Dentistry, Jouf University, Sakaka 72345, Saudi ArabiaProsthodontic Dentistry Department, College of Dentistry, Jouf University, Sakaka 72345, Saudi ArabiaProsthodontic Dentistry Department, College of Dentistry, Jouf University, Sakaka 72345, Saudi ArabiaOral Medicine & Radiology, Department of Oral & Maxillofacial Surgery & Diagnostic Sciences, College of Dentistry, Jouf University, Sakaka 72345, Saudi ArabiaThe oral cavity is an intricate environment subjected to various chemical, physical, and thermal injuries. The effectiveness of the local and systemically administered drugs is limited mainly due to their toxicities and poor oral bioavailability that leads to the limited effectiveness of the drugs in the target tissues. To address these issues, nanoparticle drug delivery systems based on metals, liposomes, polymeric particles, and core shells have been developed in recent years. Nano drug delivery systems have applications in the treatment of patients suffering from temporomandibular joint disorders such as preventing degeneration of cartilage in patients suffering from rheumatoid arthritis and osteoarthritis and alleviating the pain along with it. The antibacterial dental applications of nano-drug delivery systems such as silver and copper-based nanoparticles include these agents used to arrest dental caries, multiple steps in root canal treatment, and patients suffering from periodontitis. Nanoparticles have been used in adjunct with antifungals to treat oral fungal infections such as candida albicans in denture wearers. Acyclovir being the most commonly used antiviral has been used in combination with nanoparticles against an array of viral infections such as the herpes simplex virus. Nanoparticles based combination agents offer more favorable drug release in a controlled manner along with efficient delivery at the site of action. This review presents an updated overview of the recently developed nanoparticles delivery systems for the management of temporomandibular joint disorders along with the treatment of different oral infections.https://www.mdpi.com/2073-4360/13/23/4175nanoparticlesdrug delivery systemsoral infectionstemporomandibular jointnanomedicineCOVID-19 |
| spellingShingle | Abhishek Lal Mohammad Khursheed Alam Naseer Ahmed Afsheen Maqsood Ruba K. Al-Qaisi Deepti Shrivastava Zainab Ali Alkhalaf Amal Mohamed Alanazi Hasna Rasheed Alshubrmi Mohammed G. Sghaireen Kumar Chandan Srivastava Nano Drug Delivery Platforms for Dental Application: Infection Control and TMJ Management—A Review Polymers nanoparticles drug delivery systems oral infections temporomandibular joint nanomedicine COVID-19 |
| title | Nano Drug Delivery Platforms for Dental Application: Infection Control and TMJ Management—A Review |
| title_full | Nano Drug Delivery Platforms for Dental Application: Infection Control and TMJ Management—A Review |
| title_fullStr | Nano Drug Delivery Platforms for Dental Application: Infection Control and TMJ Management—A Review |
| title_full_unstemmed | Nano Drug Delivery Platforms for Dental Application: Infection Control and TMJ Management—A Review |
| title_short | Nano Drug Delivery Platforms for Dental Application: Infection Control and TMJ Management—A Review |
| title_sort | nano drug delivery platforms for dental application infection control and tmj management a review |
| topic | nanoparticles drug delivery systems oral infections temporomandibular joint nanomedicine COVID-19 |
| url | https://www.mdpi.com/2073-4360/13/23/4175 |
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