Postbiotic gel relieves clinical symptoms of bacterial vaginitis by regulating the vaginal microbiota
Vaginitis is the most common disease in gynecology. Vaginal dysbiosis is a main reason of bacteria vaginitis (BV), as the disrupted microecological environment facilitates the growth of various vaginal pathogens. The most dominant bacteria in the vaginal microbiota are lactic acid bacteria, which ar...
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| Format: | Article |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1114364/full |
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| author | Xin Shen Xin Shen Xin Shen Lin Xu Zhiquan Zhang Yitong Yang Pengxian Li Teng Ma Teng Ma Teng Ma Shuai Guo Shuai Guo Shuai Guo Lai-Yu Kwok Lai-Yu Kwok Lai-Yu Kwok Zhihong Sun Zhihong Sun Zhihong Sun |
| author_facet | Xin Shen Xin Shen Xin Shen Lin Xu Zhiquan Zhang Yitong Yang Pengxian Li Teng Ma Teng Ma Teng Ma Shuai Guo Shuai Guo Shuai Guo Lai-Yu Kwok Lai-Yu Kwok Lai-Yu Kwok Zhihong Sun Zhihong Sun Zhihong Sun |
| author_sort | Xin Shen |
| collection | DOAJ |
| description | Vaginitis is the most common disease in gynecology. Vaginal dysbiosis is a main reason of bacteria vaginitis (BV), as the disrupted microecological environment facilitates the growth of various vaginal pathogens. The most dominant bacteria in the vaginal microbiota are lactic acid bacteria, which are important for maintaining vaginal health. At present, antibiotics and other drugs are often used in clinical treatment, but there are many adverse reactions and easy to relapse, and the intervention of probiotics can help restore vaginal microbiota and alleviate BV. This study is a human clinical trial of 50 patients with bacterial vaginitis (BV). The alleviation effect of applying a postbiotic gel for one week in BV was evaluated. Changes in patients’ clinical indicators of BV (properties of vaginal secretion) and the vaginal microbiota after using the postbiotic gel were monitored. Our results showed that apply the postbiotic gel improved the symptoms of BV, indicated by improvement in the abnormalities of patients’ vaginal secretions. After applying the gel, the relative abundance of vaginal lactobacilli increased compared to baseline. Significant negative correlations were found between lactobacilli and potential vaginal pathogens (including Gardnerella, Prevotella, and Atopobium), as well as the abnormalities of the vaginal secretion. Overall, our results showed that applying the postbiotic gel ameliorated BV, and the symptom improvement was accompanied by significant changes in the bacterial vaginal microbiota. Our study provides valuable clinical data in managing BV. |
| first_indexed | 2024-04-10T17:41:48Z |
| format | Article |
| id | doaj.art-2034575c4aa54ab59de44abbb82b8ed9 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-10T17:41:48Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-2034575c4aa54ab59de44abbb82b8ed92023-02-03T08:47:01ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-02-011310.3389/fcimb.2023.11143641114364Postbiotic gel relieves clinical symptoms of bacterial vaginitis by regulating the vaginal microbiotaXin Shen0Xin Shen1Xin Shen2Lin Xu3Zhiquan Zhang4Yitong Yang5Pengxian Li6Teng Ma7Teng Ma8Teng Ma9Shuai Guo10Shuai Guo11Shuai Guo12Lai-Yu Kwok13Lai-Yu Kwok14Lai-Yu Kwok15Zhihong Sun16Zhihong Sun17Zhihong Sun18Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, ChinaKey Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, ChinaKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, ChinaDepartment of Gynecology, Kunming Tongren Hospital, Kunming, Yunnan, ChinaQingyitang Industrial Co., Ltd., Yunnan, ChinaQingyitang Industrial Co., Ltd., Yunnan, ChinaQingyitang Industrial Co., Ltd., Yunnan, ChinaInner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, ChinaKey Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, ChinaKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, ChinaInner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, ChinaKey Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, ChinaKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, ChinaInner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, ChinaKey Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, ChinaKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, ChinaInner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, ChinaKey Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, ChinaKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, ChinaVaginitis is the most common disease in gynecology. Vaginal dysbiosis is a main reason of bacteria vaginitis (BV), as the disrupted microecological environment facilitates the growth of various vaginal pathogens. The most dominant bacteria in the vaginal microbiota are lactic acid bacteria, which are important for maintaining vaginal health. At present, antibiotics and other drugs are often used in clinical treatment, but there are many adverse reactions and easy to relapse, and the intervention of probiotics can help restore vaginal microbiota and alleviate BV. This study is a human clinical trial of 50 patients with bacterial vaginitis (BV). The alleviation effect of applying a postbiotic gel for one week in BV was evaluated. Changes in patients’ clinical indicators of BV (properties of vaginal secretion) and the vaginal microbiota after using the postbiotic gel were monitored. Our results showed that apply the postbiotic gel improved the symptoms of BV, indicated by improvement in the abnormalities of patients’ vaginal secretions. After applying the gel, the relative abundance of vaginal lactobacilli increased compared to baseline. Significant negative correlations were found between lactobacilli and potential vaginal pathogens (including Gardnerella, Prevotella, and Atopobium), as well as the abnormalities of the vaginal secretion. Overall, our results showed that applying the postbiotic gel ameliorated BV, and the symptom improvement was accompanied by significant changes in the bacterial vaginal microbiota. Our study provides valuable clinical data in managing BV.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1114364/fullbacterial vaginitislactobacilliGardnerellavaginal microbiotapostbiotic |
| spellingShingle | Xin Shen Xin Shen Xin Shen Lin Xu Zhiquan Zhang Yitong Yang Pengxian Li Teng Ma Teng Ma Teng Ma Shuai Guo Shuai Guo Shuai Guo Lai-Yu Kwok Lai-Yu Kwok Lai-Yu Kwok Zhihong Sun Zhihong Sun Zhihong Sun Postbiotic gel relieves clinical symptoms of bacterial vaginitis by regulating the vaginal microbiota Frontiers in Cellular and Infection Microbiology bacterial vaginitis lactobacilli Gardnerella vaginal microbiota postbiotic |
| title | Postbiotic gel relieves clinical symptoms of bacterial vaginitis by regulating the vaginal microbiota |
| title_full | Postbiotic gel relieves clinical symptoms of bacterial vaginitis by regulating the vaginal microbiota |
| title_fullStr | Postbiotic gel relieves clinical symptoms of bacterial vaginitis by regulating the vaginal microbiota |
| title_full_unstemmed | Postbiotic gel relieves clinical symptoms of bacterial vaginitis by regulating the vaginal microbiota |
| title_short | Postbiotic gel relieves clinical symptoms of bacterial vaginitis by regulating the vaginal microbiota |
| title_sort | postbiotic gel relieves clinical symptoms of bacterial vaginitis by regulating the vaginal microbiota |
| topic | bacterial vaginitis lactobacilli Gardnerella vaginal microbiota postbiotic |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1114364/full |
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