Nrdp1 Increases Ischemia Induced Primary Rat Cerebral Cortical Neurons and Pheochromocytoma Cells Apoptosis Via Downregulation of HIF-1α Protein

Nrdp1 Increases Ischemia Induced Primary Rat Cerebral Cortical Neurons and Pheochromocytoma Cells Apoptosis Via Downregulation of HIF-1α Protein

Neuregulin receptor degradation protein-1 (Nrdp1) is an E3 ubiquitin ligase that targets proteins for degradation and regulates cell growth, apoptosis and oxidative stress in various cell types. We have previously shown that Nrdp1 is implicated in ischemic cardiomyocyte death. In this study, we inve...

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Bibliographic Details
Main Authors: Yuan Zhang, Ke Yang, Ting Wang, Weiping Li, Xinchun Jin, Wenlan Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
ischemic stroke
neuronal injury
Nrdp1
apoptosis
HIF-1α
USP8
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00293/full

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