The effectiveness of zinc supplementation in men with isolated hypogonadotropic hypogonadism
A multicenter, open-label, randomized, controlled superiority trial with 18 months of follow-up was conducted to investigate whether oral zinc supplementation could further promote spermatogenesis in males with isolated hypogonadotropic hypogonadism (IHH) receiving sequential purified urinary follic...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Asian Journal of Andrology |
| Subjects: | |
| Online Access: | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2017;volume=19;issue=3;spage=280;epage=285;aulast=Liu |
| _version_ | 1818066568680046592 |
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| author | Yan-Ling Liu Man-Na Zhang Guo-Yu Tong Shou-Yue Sun Yan-Hua Zhu Ying Cao Jie Zhang Hong Huang Ben Niu Hong Li Qing-Hua Guo Yan Gao Da-Long Zhu Xiao-Ying Li on behalf of Hypogonadotropic Hypogonadism Intervention Study (HHIS) Group |
| author_facet | Yan-Ling Liu Man-Na Zhang Guo-Yu Tong Shou-Yue Sun Yan-Hua Zhu Ying Cao Jie Zhang Hong Huang Ben Niu Hong Li Qing-Hua Guo Yan Gao Da-Long Zhu Xiao-Ying Li on behalf of Hypogonadotropic Hypogonadism Intervention Study (HHIS) Group |
| author_sort | Yan-Ling Liu |
| collection | DOAJ |
| description | A multicenter, open-label, randomized, controlled superiority trial with 18 months of follow-up was conducted to investigate whether oral zinc supplementation could further promote spermatogenesis in males with isolated hypogonadotropic hypogonadism (IHH) receiving sequential purified urinary follicular-stimulating hormone/human chorionic gonadotropin (uFSH/hCG) replacement. Sixty-seven Chinese male IHH patients were recruited from the Departments of Endocrinology in eight tertiary hospitals and randomly allocated into the sequential uFSH/hCG group (Group A, n = 34) or the sequential uFSH plus zinc supplementation group (Group B, n = 33). In Group A, patients received sequential uFSH (75 U, three times a week every other 3 months) and hCG (2000 U, twice a week) treatments. In Group B, patients received oral zinc supplementation (40 mg day−1 ) in addition to the sequential uFSH/hCG treatment given to patients in Group A. The primary outcome was the proportion of patients with a sperm concentration ≥1.0 × 106 ml−1 during the 18 months. The comparison of efficacy between Groups A and B was analyzed. Nineteen of 34 (55.9%) patients receiving sequential uFSH/hCG and 20 of 33 (60.6%) patients receiving sequential uFSH/hCG plus zinc supplementation achieved sperm concentrations ≥1.0 × 106 ml−1 by intention to treat analyses. No differences between Group A and Group B were observed as far as the efficacy of inducing spermatogenesis (P = 0.69). We concluded that the sequential uFSH/hCG plus zinc supplementation regimen had a similar efficacy to the sequential uFSH/hCG treatment alone. The additional improvement of 40 mg day−1 oral zinc supplementation on spermatogenesis and masculinization in male IHH patients is very subtle. |
| first_indexed | 2024-12-10T15:09:52Z |
| format | Article |
| id | doaj.art-203689f387af41dd8281377c4dd03b43 |
| institution | Directory Open Access Journal |
| issn | 1008-682X 1745-7262 |
| language | English |
| last_indexed | 2024-12-10T15:09:52Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Andrology |
| spelling | doaj.art-203689f387af41dd8281377c4dd03b432022-12-22T01:43:57ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X1745-72622017-01-0119328028510.4103/1008-682X.189621The effectiveness of zinc supplementation in men with isolated hypogonadotropic hypogonadismYan-Ling LiuMan-Na ZhangGuo-Yu TongShou-Yue SunYan-Hua ZhuYing CaoJie ZhangHong HuangBen NiuHong LiQing-Hua GuoYan GaoDa-Long ZhuXiao-Ying Lion behalf of Hypogonadotropic Hypogonadism Intervention Study (HHIS) GroupA multicenter, open-label, randomized, controlled superiority trial with 18 months of follow-up was conducted to investigate whether oral zinc supplementation could further promote spermatogenesis in males with isolated hypogonadotropic hypogonadism (IHH) receiving sequential purified urinary follicular-stimulating hormone/human chorionic gonadotropin (uFSH/hCG) replacement. Sixty-seven Chinese male IHH patients were recruited from the Departments of Endocrinology in eight tertiary hospitals and randomly allocated into the sequential uFSH/hCG group (Group A, n = 34) or the sequential uFSH plus zinc supplementation group (Group B, n = 33). In Group A, patients received sequential uFSH (75 U, three times a week every other 3 months) and hCG (2000 U, twice a week) treatments. In Group B, patients received oral zinc supplementation (40 mg day−1 ) in addition to the sequential uFSH/hCG treatment given to patients in Group A. The primary outcome was the proportion of patients with a sperm concentration ≥1.0 × 106 ml−1 during the 18 months. The comparison of efficacy between Groups A and B was analyzed. Nineteen of 34 (55.9%) patients receiving sequential uFSH/hCG and 20 of 33 (60.6%) patients receiving sequential uFSH/hCG plus zinc supplementation achieved sperm concentrations ≥1.0 × 106 ml−1 by intention to treat analyses. No differences between Group A and Group B were observed as far as the efficacy of inducing spermatogenesis (P = 0.69). We concluded that the sequential uFSH/hCG plus zinc supplementation regimen had a similar efficacy to the sequential uFSH/hCG treatment alone. The additional improvement of 40 mg day−1 oral zinc supplementation on spermatogenesis and masculinization in male IHH patients is very subtle.http://www.ajandrology.com/article.asp?issn=1008-682X;year=2017;volume=19;issue=3;spage=280;epage=285;aulast=Liugonadotropin; isolated hypogonadotropic hypogonadism; masculinization; spermatogenesis; zinc supplementation |
| spellingShingle | Yan-Ling Liu Man-Na Zhang Guo-Yu Tong Shou-Yue Sun Yan-Hua Zhu Ying Cao Jie Zhang Hong Huang Ben Niu Hong Li Qing-Hua Guo Yan Gao Da-Long Zhu Xiao-Ying Li on behalf of Hypogonadotropic Hypogonadism Intervention Study (HHIS) Group The effectiveness of zinc supplementation in men with isolated hypogonadotropic hypogonadism Asian Journal of Andrology gonadotropin; isolated hypogonadotropic hypogonadism; masculinization; spermatogenesis; zinc supplementation |
| title | The effectiveness of zinc supplementation in men with isolated hypogonadotropic hypogonadism |
| title_full | The effectiveness of zinc supplementation in men with isolated hypogonadotropic hypogonadism |
| title_fullStr | The effectiveness of zinc supplementation in men with isolated hypogonadotropic hypogonadism |
| title_full_unstemmed | The effectiveness of zinc supplementation in men with isolated hypogonadotropic hypogonadism |
| title_short | The effectiveness of zinc supplementation in men with isolated hypogonadotropic hypogonadism |
| title_sort | effectiveness of zinc supplementation in men with isolated hypogonadotropic hypogonadism |
| topic | gonadotropin; isolated hypogonadotropic hypogonadism; masculinization; spermatogenesis; zinc supplementation |
| url | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2017;volume=19;issue=3;spage=280;epage=285;aulast=Liu |
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