The TFPI2–PPARγ axis induces M2 polarization and inhibits fibroblast activation to promote recovery from post-myocardial infarction in diabetic mice

The TFPI2–PPARγ axis induces M2 polarization and inhibits fibroblast activation to promote recovery from post-myocardial infarction in diabetic mice

Abstract Background Diabetes mellitus is one of the causes of poor ventricular remodelling and poor cardiac recovery after myocardial infarction (MI). We previously reported that tissue factor pathway inhibitor-2 (TFPI2) was downregulated in response to hyperglycaemia and that it played a pivotal ro...

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Bibliographic Details
Main Authors: Mengqi Guo, Zongyi Xia, Yefeng Hong, Hongwei Ji, Fuhai Li, Wenheng Liu, Shaohua Li, Hui Xin, Kai Tan, Zhexun Lian
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Inflammation
Subjects:
Tissue factor pathway inhibitor-2
Diabetes mellitus
Myocardial infarction
Fibroblast migration
MMPs
Collagen
Online Access:https://doi.org/10.1186/s12950-023-00357-8

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