Inhibition of the Antigen Provoked Nasal Reaction by Second-generation Antihistamines in Patients with Japanese Cedar Pollinosis
Background: Epinastine hydrochloride and fexofenadine hydrochloride, the second-generation antihistamines, are largely used in the indication of allergic rhinitis in Japan. The purpose of this study was to compare the protective efficacy of epinastine hydrochloride or fexofenadine hydrochloride usin...
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2006-01-01
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| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893015309758 |
| _version_ | 1818036492044337152 |
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| author | Kimihiro Okubo Minoru Gotoh |
| author_facet | Kimihiro Okubo Minoru Gotoh |
| author_sort | Kimihiro Okubo |
| collection | DOAJ |
| description | Background: Epinastine hydrochloride and fexofenadine hydrochloride, the second-generation antihistamines, are largely used in the indication of allergic rhinitis in Japan. The purpose of this study was to compare the protective efficacy of epinastine hydrochloride or fexofenadine hydrochloride using a nasal provocation test with Japanese cedar pollen allergen.
Methods: A single-dose, placebo-controlled, single-blind crossover clinical study was conducted in patients with Japanese cedar pollinosis. The pollen exposure was done by the antigen provocation by disc method and involved repeated provocation five times per day.
Results: Among the active agents studied—epinastine hydrochloride and fexofenadine hydrochloride—epinastine hydrochloride significantly decreased the number of sneezing attacks and the quantity of nasal discharge for 3 hours after drug administration compared with placebo, a finding supported by the quantity of nasal discharge in the nasal findings. In this study, fexofenadine hydrochloride showed no significant difference compared with placebo.
Conclusions: This study demonstrates better protection with epinastine hydrochloride than with fexofenadine hydrochloride or placebo in a nasal provocation test with Japanese cedar pollen allergen. |
| first_indexed | 2024-12-10T07:11:48Z |
| format | Article |
| id | doaj.art-2037cb4e23144483a94fcb24b95f9651 |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-12-10T07:11:48Z |
| publishDate | 2006-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-2037cb4e23144483a94fcb24b95f96512022-12-22T01:58:01ZengElsevierAllergology International1323-89302006-01-0155326126910.2332/allergolint.55.261Inhibition of the Antigen Provoked Nasal Reaction by Second-generation Antihistamines in Patients with Japanese Cedar PollinosisKimihiro Okubo0Minoru Gotoh1Departments of Otorhinolaryngology and Head/Neck Surgery, Nippon Medical School, Tokyo, JapanDepartment of Otorhinolaryngology, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan.Background: Epinastine hydrochloride and fexofenadine hydrochloride, the second-generation antihistamines, are largely used in the indication of allergic rhinitis in Japan. The purpose of this study was to compare the protective efficacy of epinastine hydrochloride or fexofenadine hydrochloride using a nasal provocation test with Japanese cedar pollen allergen. Methods: A single-dose, placebo-controlled, single-blind crossover clinical study was conducted in patients with Japanese cedar pollinosis. The pollen exposure was done by the antigen provocation by disc method and involved repeated provocation five times per day. Results: Among the active agents studied—epinastine hydrochloride and fexofenadine hydrochloride—epinastine hydrochloride significantly decreased the number of sneezing attacks and the quantity of nasal discharge for 3 hours after drug administration compared with placebo, a finding supported by the quantity of nasal discharge in the nasal findings. In this study, fexofenadine hydrochloride showed no significant difference compared with placebo. Conclusions: This study demonstrates better protection with epinastine hydrochloride than with fexofenadine hydrochloride or placebo in a nasal provocation test with Japanese cedar pollen allergen.http://www.sciencedirect.com/science/article/pii/S1323893015309758allergic rhinitisepinastine hydrochloridefexofenadine hydrochloridenasal provocationrhinoscopy |
| spellingShingle | Kimihiro Okubo Minoru Gotoh Inhibition of the Antigen Provoked Nasal Reaction by Second-generation Antihistamines in Patients with Japanese Cedar Pollinosis Allergology International allergic rhinitis epinastine hydrochloride fexofenadine hydrochloride nasal provocation rhinoscopy |
| title | Inhibition of the Antigen Provoked Nasal Reaction by Second-generation Antihistamines in Patients with Japanese Cedar Pollinosis |
| title_full | Inhibition of the Antigen Provoked Nasal Reaction by Second-generation Antihistamines in Patients with Japanese Cedar Pollinosis |
| title_fullStr | Inhibition of the Antigen Provoked Nasal Reaction by Second-generation Antihistamines in Patients with Japanese Cedar Pollinosis |
| title_full_unstemmed | Inhibition of the Antigen Provoked Nasal Reaction by Second-generation Antihistamines in Patients with Japanese Cedar Pollinosis |
| title_short | Inhibition of the Antigen Provoked Nasal Reaction by Second-generation Antihistamines in Patients with Japanese Cedar Pollinosis |
| title_sort | inhibition of the antigen provoked nasal reaction by second generation antihistamines in patients with japanese cedar pollinosis |
| topic | allergic rhinitis epinastine hydrochloride fexofenadine hydrochloride nasal provocation rhinoscopy |
| url | http://www.sciencedirect.com/science/article/pii/S1323893015309758 |
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