Halogenated Pyrrolopyrimidines with Low MIC on <i>Staphylococcus aureus</i> and Synergistic Effects with an Antimicrobial Peptide
Currently, there is a world-wide rise in antibiotic resistance causing burdens to individuals and public healthcare systems. At the same time drug development is lagging behind. Therefore, finding new ways of treating bacterial infections either by identifying new agents or combinations of drugs is...
Main Authors: | Cecilie Elisabeth Olsen, Fredrik Heen Blindheim, Caroline Krogh Søgaard, Lisa Marie Røst, Amanda Holstad Singleton, Olaug Elisabeth Torheim Bergum, Per Bruheim, Marit Otterlei, Eirik Sundby, Bård Helge Hoff |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-07-01
|
Series: | Antibiotics |
Subjects: | |
Online Access: | https://www.mdpi.com/2079-6382/11/8/984 |
Similar Items
-
Activation of multiple stress responses in Staphylococcus aureus substantially lowers the minimal inhibitory concentration when combining two novel antibiotic drug candidates
by: Amanda Holstad Singleton, et al.
Published: (2023-09-01) -
Identification of a Biosynthetic Gene Cluster Responsible for the Production of a New Pyrrolopyrimidine Natural Product—Huimycin
by: Hui Shuai, et al.
Published: (2020-07-01) -
The study of the neurotropic activity of the pyrrolopyrimidin-4-ones rearrangement products under the action of phosphorus oxychloride
by: Ekaterina V. Zaliznaya, et al.
Published: (2020-03-01) -
Novel pyrrolopyrimidine derivatives: design, synthesis, molecular docking, molecular simulations and biological evaluations as antioxidant and anti-inflammatory agents
by: Amira I. Sayed, et al.
Published: (2022-12-01) -
QSAR modelling, molecular docking, molecular dynamic and ADMET prediction of pyrrolopyrimidine derivatives as novel Bruton’s tyrosine kinase (BTK) inhibitors
by: Mourad Aloui, et al.
Published: (2024-01-01)