Sodium selenite antagonizes trimethyl tin-induced chicken hepatotoxic hepatitis through the RNS/NF-κB/NLRP3 pathway
Trimethyl tin (TMT) is a good stabilizer for plastic products but is also a toxic environmental pollutant. Selenium has good antioxidant and anti-inflammatory properties and has been widely used in the poultry industry. However, it has not been reported whether selenium enrichment can antagonize TMT...
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| Format: | Article |
| Sprog: | English |
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Elsevier
2025-01-01
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| Serier: | Poultry Science |
| Fag: | |
| Online adgang: | http://www.sciencedirect.com/science/article/pii/S0032579124010277 |
| _version_ | 1826860776453832704 |
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| author | Xinzhang Chen Xu Lin |
| author_facet | Xinzhang Chen Xu Lin |
| author_sort | Xinzhang Chen |
| collection | DOAJ |
| description | Trimethyl tin (TMT) is a good stabilizer for plastic products but is also a toxic environmental pollutant. Selenium has good antioxidant and anti-inflammatory properties and has been widely used in the poultry industry. However, it has not been reported whether selenium enrichment can antagonize TMT-induced viral hepatitis in poultry. To fill this gap, AA broiler models exposed to TMT for 42 d were established and fed a Se-enriched diet at the same time. H&E staining showed that selenium could significantly alleviate TMT-induced liver inflammation. Further analysis of the underlying mechanism revealed that TMT induced nitrosation stress (RNS), increased NO content and iNOS expression, which in turn activated the NF-κB/NLRP3 pathway and induced pyroptosis. However, selenium enrichment can reverse this situation, that is, reduce the occurrence of RNS, reduce the degree of pyroptosis, and thus alleviate the occurrence of inflammation. In our study, we demonstrated for the first time that TMT could induce hepatotoxicity other than neurotoxicity in poultry and that selenium could antagonize TMT-induced hepatotoxic hepatitis in chickens through the RNS/NF-κB/NLRP3 pathway. |
| first_indexed | 2025-02-16T20:02:50Z |
| format | Article |
| id | doaj.art-203b9cc916e84f1184645b0ba1fd1332 |
| institution | Directory Open Access Journal |
| issn | 0032-5791 |
| language | English |
| last_indexed | 2025-02-16T20:02:50Z |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Poultry Science |
| spelling | doaj.art-203b9cc916e84f1184645b0ba1fd13322025-01-22T05:40:09ZengElsevierPoultry Science0032-57912025-01-011041104449Sodium selenite antagonizes trimethyl tin-induced chicken hepatotoxic hepatitis through the RNS/NF-κB/NLRP3 pathwayXinzhang Chen0Xu Lin1College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Animal Science Faculty of Technology, Northeast Agricultural University, Harbin 150030, PR ChinaAnimal Science Faculty of Technology, Northeast Agricultural University, Harbin 150030, PR China; Corresponding author at: Animal Science Faculty of Technology, Northeast Agricultural University, Harbin 150030, PR China.Trimethyl tin (TMT) is a good stabilizer for plastic products but is also a toxic environmental pollutant. Selenium has good antioxidant and anti-inflammatory properties and has been widely used in the poultry industry. However, it has not been reported whether selenium enrichment can antagonize TMT-induced viral hepatitis in poultry. To fill this gap, AA broiler models exposed to TMT for 42 d were established and fed a Se-enriched diet at the same time. H&E staining showed that selenium could significantly alleviate TMT-induced liver inflammation. Further analysis of the underlying mechanism revealed that TMT induced nitrosation stress (RNS), increased NO content and iNOS expression, which in turn activated the NF-κB/NLRP3 pathway and induced pyroptosis. However, selenium enrichment can reverse this situation, that is, reduce the occurrence of RNS, reduce the degree of pyroptosis, and thus alleviate the occurrence of inflammation. In our study, we demonstrated for the first time that TMT could induce hepatotoxicity other than neurotoxicity in poultry and that selenium could antagonize TMT-induced hepatotoxic hepatitis in chickens through the RNS/NF-κB/NLRP3 pathway.http://www.sciencedirect.com/science/article/pii/S0032579124010277ChickenTMTLiverRNSPyroptosis |
| spellingShingle | Xinzhang Chen Xu Lin Sodium selenite antagonizes trimethyl tin-induced chicken hepatotoxic hepatitis through the RNS/NF-κB/NLRP3 pathway Poultry Science Chicken TMT Liver RNS Pyroptosis |
| title | Sodium selenite antagonizes trimethyl tin-induced chicken hepatotoxic hepatitis through the RNS/NF-κB/NLRP3 pathway |
| title_full | Sodium selenite antagonizes trimethyl tin-induced chicken hepatotoxic hepatitis through the RNS/NF-κB/NLRP3 pathway |
| title_fullStr | Sodium selenite antagonizes trimethyl tin-induced chicken hepatotoxic hepatitis through the RNS/NF-κB/NLRP3 pathway |
| title_full_unstemmed | Sodium selenite antagonizes trimethyl tin-induced chicken hepatotoxic hepatitis through the RNS/NF-κB/NLRP3 pathway |
| title_short | Sodium selenite antagonizes trimethyl tin-induced chicken hepatotoxic hepatitis through the RNS/NF-κB/NLRP3 pathway |
| title_sort | sodium selenite antagonizes trimethyl tin induced chicken hepatotoxic hepatitis through the rns nf κb nlrp3 pathway |
| topic | Chicken TMT Liver RNS Pyroptosis |
| url | http://www.sciencedirect.com/science/article/pii/S0032579124010277 |
| work_keys_str_mv | AT xinzhangchen sodiumseleniteantagonizestrimethyltininducedchickenhepatotoxichepatitisthroughthernsnfkbnlrp3pathway AT xulin sodiumseleniteantagonizestrimethyltininducedchickenhepatotoxichepatitisthroughthernsnfkbnlrp3pathway |