Retinal nerve fiber layer sector-specific compromise in relapsing and remitting multiple sclerosis
Objective: To evaluate quadrant and sector retinal nerve fiber layer (RNFL) thickness and total macular volume (TMV) in relapsing–remitting multiple sclerosis (RR-MS) patients. Methods: Optical coherence tomography measures of RNFL and TMV were studied in 321 eyes without prior optic neuritis (ON) (...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-06-01
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| Series: | eNeurologicalSci |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405650215000106 |
| _version_ | 1818678567908671488 |
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| author | Anette S. Loughran-Fjeldstad Noel G. Carlson Cassandra D. Husebye Lawrence J. Cook John W. Rose |
| author_facet | Anette S. Loughran-Fjeldstad Noel G. Carlson Cassandra D. Husebye Lawrence J. Cook John W. Rose |
| author_sort | Anette S. Loughran-Fjeldstad |
| collection | DOAJ |
| description | Objective: To evaluate quadrant and sector retinal nerve fiber layer (RNFL) thickness and total macular volume (TMV) in relapsing–remitting multiple sclerosis (RR-MS) patients.
Methods: Optical coherence tomography measures of RNFL and TMV were studied in 321 eyes without prior optic neuritis (ON) (MS unaffected), 151 eyes with prior ON (MS affected), and 148 healthy control eyes.
Results: Mean RNFL thickness was significantly lower in the MS affected and MS unaffected groups relative to the control group (p < 0.0001). RNFL thicknesses in the superior, inferior, and temporal quadrants were significantly reduced in MS unaffected (113 ± 15 μm, 119 ± 17 μm, 63 ± 13 μm) (p < 0.001) and MS affected groups (99 ± 19 μm, 103 ± 21 μm, 51 ± 13 μm) (p < 0.0001) compared with that in controls (120 ± 14 μm, 128 ± 15 μm, 69 ± 8 μm, respectively). TMV was significantly reduced in both the MS affected and MS unaffected groups compared with that in the controls (p < 0.0001).
Conclusion: Quadrant, sector, and PMB RNFL thicknesses are significant individual measures in RR-MS for both affected and unaffected eyes and may prove valuable in future investigations including biomarker and outcomes research. |
| first_indexed | 2024-12-17T09:17:19Z |
| format | Article |
| id | doaj.art-203c013992024ea799fc25ac7baf3cfb |
| institution | Directory Open Access Journal |
| issn | 2405-6502 |
| language | English |
| last_indexed | 2024-12-17T09:17:19Z |
| publishDate | 2015-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | eNeurologicalSci |
| spelling | doaj.art-203c013992024ea799fc25ac7baf3cfb2022-12-21T21:54:55ZengElseviereNeurologicalSci2405-65022015-06-0112303710.1016/j.ensci.2015.09.004Retinal nerve fiber layer sector-specific compromise in relapsing and remitting multiple sclerosisAnette S. Loughran-Fjeldstad0Noel G. Carlson1Cassandra D. Husebye2Lawrence J. Cook3John W. Rose4Department of Neurology, University of Utah, 729 Arapeen Drive, Salt Lake City, UT 84108, USANeurovirology Research, VA SLC HCS, GRECC, 500 Foothill Drive, Salt Lake City, UT 84148, USADepartment of Neurology, University of Utah, 729 Arapeen Drive, Salt Lake City, UT 84108, USADepartment of Pediatrics, University of Utah, 295 Chipeta Way, Salt Lake City, UT 84108, USADepartment of Neurology, University of Utah, 729 Arapeen Drive, Salt Lake City, UT 84108, USAObjective: To evaluate quadrant and sector retinal nerve fiber layer (RNFL) thickness and total macular volume (TMV) in relapsing–remitting multiple sclerosis (RR-MS) patients. Methods: Optical coherence tomography measures of RNFL and TMV were studied in 321 eyes without prior optic neuritis (ON) (MS unaffected), 151 eyes with prior ON (MS affected), and 148 healthy control eyes. Results: Mean RNFL thickness was significantly lower in the MS affected and MS unaffected groups relative to the control group (p < 0.0001). RNFL thicknesses in the superior, inferior, and temporal quadrants were significantly reduced in MS unaffected (113 ± 15 μm, 119 ± 17 μm, 63 ± 13 μm) (p < 0.001) and MS affected groups (99 ± 19 μm, 103 ± 21 μm, 51 ± 13 μm) (p < 0.0001) compared with that in controls (120 ± 14 μm, 128 ± 15 μm, 69 ± 8 μm, respectively). TMV was significantly reduced in both the MS affected and MS unaffected groups compared with that in the controls (p < 0.0001). Conclusion: Quadrant, sector, and PMB RNFL thicknesses are significant individual measures in RR-MS for both affected and unaffected eyes and may prove valuable in future investigations including biomarker and outcomes research.http://www.sciencedirect.com/science/article/pii/S2405650215000106Axonal lossMultiple sclerosisOptic neuritisOptical coherence tomographyRetinal nerve fiber layerTotal macular volume |
| spellingShingle | Anette S. Loughran-Fjeldstad Noel G. Carlson Cassandra D. Husebye Lawrence J. Cook John W. Rose Retinal nerve fiber layer sector-specific compromise in relapsing and remitting multiple sclerosis eNeurologicalSci Axonal loss Multiple sclerosis Optic neuritis Optical coherence tomography Retinal nerve fiber layer Total macular volume |
| title | Retinal nerve fiber layer sector-specific compromise in relapsing and remitting multiple sclerosis |
| title_full | Retinal nerve fiber layer sector-specific compromise in relapsing and remitting multiple sclerosis |
| title_fullStr | Retinal nerve fiber layer sector-specific compromise in relapsing and remitting multiple sclerosis |
| title_full_unstemmed | Retinal nerve fiber layer sector-specific compromise in relapsing and remitting multiple sclerosis |
| title_short | Retinal nerve fiber layer sector-specific compromise in relapsing and remitting multiple sclerosis |
| title_sort | retinal nerve fiber layer sector specific compromise in relapsing and remitting multiple sclerosis |
| topic | Axonal loss Multiple sclerosis Optic neuritis Optical coherence tomography Retinal nerve fiber layer Total macular volume |
| url | http://www.sciencedirect.com/science/article/pii/S2405650215000106 |
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